Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas
The purpose of this study was to investigate the relationship between high plasma fluoride levels, oxidative stress, and pregnancy complications (abortion, intrauterine fetal death, preterm birth, and preeclampsia) in women living in Settat province, Morocco. Blood samples were collected from pregn...
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University of Baghdad, College of Science for Women
2024-04-01
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| Series: | مجلة بغداد للعلوم |
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| Online Access: | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8293 |
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| author | Lalla Asmaa Katir Masnaoui Habiba Bouchab Abdellatif Rahim Riad El Kebbaj Abdelkhalid Essamadi |
| author_facet | Lalla Asmaa Katir Masnaoui Habiba Bouchab Abdellatif Rahim Riad El Kebbaj Abdelkhalid Essamadi |
| author_sort | Lalla Asmaa Katir Masnaoui |
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The purpose of this study was to investigate the relationship between high plasma fluoride levels, oxidative stress, and pregnancy complications (abortion, intrauterine fetal death, preterm birth, and preeclampsia) in women living in Settat province, Morocco. Blood samples were collected from pregnant women with normal gestation (n=60), abortion (n=20), intrauterine fetal death (n=10), premature delivery (n=20), and preeclampsia (n=20). Afterwards, plasma fluoride levels and erythrocyte enzymatic activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined. The results revealed that plasma fluoride levels were significantly lower in women who had normal pregnancies, with a concentration of 0.030±0.003 mg/l, compared to those presenting with abortion, intrauterine fetal death, preterm birth, and preeclampsia, with concentrations of 0.040±0.002, 0.037±0.002, 0.034±0.004 and 0.034±0.003 mg/l, respectively. In addition, SOD activity was significantly increased in women with pregnancy complications, whereas CAT and GPx activities were decreased compared to women with normal pregnancies. Moreover, there was a strong correlation between plasma fluoride levels, antioxidant activities, and pregnancy complications. The presence of high plasma fluoride levels could lead to an increase in the prevalence of abortion, intrauterine fetal death, preterm birth, and preeclampsia, via the oxidative stress pathway in pregnant women living in Settat province, Morocco.
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| format | Article |
| id | doaj-art-93111d31ea8c4523aee7f5b77c042cdc |
| institution | Kabale University |
| issn | 2078-8665 2411-7986 |
| language | English |
| publishDate | 2024-04-01 |
| publisher | University of Baghdad, College of Science for Women |
| record_format | Article |
| series | مجلة بغداد للعلوم |
| spelling | doaj-art-93111d31ea8c4523aee7f5b77c042cdc2025-08-20T03:36:57ZengUniversity of Baghdad, College of Science for Womenمجلة بغداد للعلوم2078-86652411-79862024-04-0121410.21123/bsj.2023.8293Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis AreasLalla Asmaa Katir Masnaoui0https://orcid.org/0000-0001-5866-1539Habiba Bouchab1https://orcid.org/0000-0002-2632-7840Abdellatif Rahim2https://orcid.org/0000-0001-5832-1710Riad El Kebbaj3Abdelkhalid Essamadi4https://orcid.org/0000-0003-4537-1684Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco.Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco & Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University, Settat 26000, Morocco.Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco.Laboratory of Health Sciences and Technologies, Higher Institute of Health Sciences, Hassan First University, Settat 26000, Morocco.Laboratory of Biochemistry, Neurosciences, Natural Resources and Environment, Faculty of Sciences and Technologies, Hassan First University, Settat 26000, Morocco. The purpose of this study was to investigate the relationship between high plasma fluoride levels, oxidative stress, and pregnancy complications (abortion, intrauterine fetal death, preterm birth, and preeclampsia) in women living in Settat province, Morocco. Blood samples were collected from pregnant women with normal gestation (n=60), abortion (n=20), intrauterine fetal death (n=10), premature delivery (n=20), and preeclampsia (n=20). Afterwards, plasma fluoride levels and erythrocyte enzymatic activities of superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) were determined. The results revealed that plasma fluoride levels were significantly lower in women who had normal pregnancies, with a concentration of 0.030±0.003 mg/l, compared to those presenting with abortion, intrauterine fetal death, preterm birth, and preeclampsia, with concentrations of 0.040±0.002, 0.037±0.002, 0.034±0.004 and 0.034±0.003 mg/l, respectively. In addition, SOD activity was significantly increased in women with pregnancy complications, whereas CAT and GPx activities were decreased compared to women with normal pregnancies. Moreover, there was a strong correlation between plasma fluoride levels, antioxidant activities, and pregnancy complications. The presence of high plasma fluoride levels could lead to an increase in the prevalence of abortion, intrauterine fetal death, preterm birth, and preeclampsia, via the oxidative stress pathway in pregnant women living in Settat province, Morocco. https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8293Fluoride, normal pregnancy, oxidative stress, pregnancy complications, women |
| spellingShingle | Lalla Asmaa Katir Masnaoui Habiba Bouchab Abdellatif Rahim Riad El Kebbaj Abdelkhalid Essamadi Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas مجلة بغداد للعلوم Fluoride, normal pregnancy, oxidative stress, pregnancy complications, women |
| title | Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas |
| title_full | Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas |
| title_fullStr | Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas |
| title_full_unstemmed | Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas |
| title_short | Association between Fluoride Toxicity, Oxidative Stress, and Pregnancy Complications in Women Living in Fluorosis Areas |
| title_sort | association between fluoride toxicity oxidative stress and pregnancy complications in women living in fluorosis areas |
| topic | Fluoride, normal pregnancy, oxidative stress, pregnancy complications, women |
| url | https://bsj.uobaghdad.edu.iq/index.php/BSJ/article/view/8293 |
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