ANXA1 promotes intrahepatic cholangiocarcinoma proliferation and growth by regulating glutamine metabolism through GOT1 stabilization

ANXA1 promotes intrahepatic cholangiocarcinoma proliferation and growth by regulating glutamine metabolism through GOT1 stabilization

Abstract Background Intrahepatic cholangiocarcinoma (ICC) is a malignant tumor with a poor prognosis, marked by a postoperative recurrence rate of 50–60% and a 5-year survival rate of 8–30%. Abnormal tumor metabolism, particularly, amino acid metabolism, plays a key role in malignant progression. Ho...

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Bibliographic Details
Main Authors: Yanyu Gong, Liwen Chen, Hao Wang, Dijie Zheng, Futang Li, Changhao Wu, Yongning Li, Yazhu Deng, Zhiwei He, Chao Yu
Format: Article
Language:English
Published: BMC 2025-05-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
ICC
ANXA1
GOT1
Glutamine metabolism
Oxidative stress
Online Access:https://doi.org/10.1186/s13046-025-03400-z
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