Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

Safety, tumor trafficking and immunogenicity of chimeric antigen receptor (CAR)-T cells specific for TAG-72 in colorectal cancer

Background T cells engineered to express chimeric antigen receptors (CARs) have established efficacy in the treatment of B-cell malignancies, but their relevance in solid tumors remains undefined. Here we report results of the first human trials of CAR-T cells in the treatment of solid tumors perfor...

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Bibliographic Details
Main Authors: Jeffrey Schlom, Carl H. June, George A. Fisher, John J. Nemunaitis, Kristen M. Hege, Emily K. Bergsland, Robert S. Warren, James G. McArthur, Andy A. Lin, Stephen A. Sherwin
Format: Article
Language:English
Published: BMJ Publishing Group 2017-01-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/5/1/22.full
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