Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies
Abstract Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to the global public health. It can result in myocardial cell damage and death due to impaired mitochondrial and endoplasmic reticulum (ER) functions. These two organelles...
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| Format: | Article |
| Language: | English |
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BMC
2025-03-01
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| Series: | Journal of Translational Medicine |
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| Online Access: | https://doi.org/10.1186/s12967-025-06262-3 |
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| author | Chen Chen Guohua Dai Maoxia Fan Xingmeng Wang Kaibin Niu Wulin Gao |
| author_facet | Chen Chen Guohua Dai Maoxia Fan Xingmeng Wang Kaibin Niu Wulin Gao |
| author_sort | Chen Chen |
| collection | DOAJ |
| description | Abstract Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to the global public health. It can result in myocardial cell damage and death due to impaired mitochondrial and endoplasmic reticulum (ER) functions. These two organelles are important regulators of cell death. In recent years, research has shifted from isolated studies of individual organelles to a more integrative approach, with a particular focus on their membrane contact sites—Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs). These dynamic microdomains play a crucial role in regulating material exchange and signal transduction between the endoplasmic reticulum and mitochondria. This review comprehensively describes the intricate structure of MAMs and their multifaceted roles in cellular pathophysiological processes. Particular focus was directed at the far-reaching effects of MAMs in regulating key pathological events including calcium homeostasis, mitochondrial dysfunction, ER stress, oxidative stress, and autophagy in ischemic heart disease (IHD). The potential treatment targets and regulatory mechanisms of MAMs were discussed and summarized, providing novel research directions and treatment approaches for improving myocardial ischemia-related diseases. Graphical Abstract |
| format | Article |
| id | doaj-art-92ffae5e41f440f384eda831689edb14 |
| institution | DOAJ |
| issn | 1479-5876 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj-art-92ffae5e41f440f384eda831689edb142025-08-20T03:05:44ZengBMCJournal of Translational Medicine1479-58762025-03-0123112310.1186/s12967-025-06262-3Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategiesChen Chen0Guohua Dai1Maoxia Fan2Xingmeng Wang3Kaibin Niu4Wulin Gao5First Clinical Medical College, Shandong University of Traditional Chinese MedicineDepartment of Geriatrics, Affiliated Hospital of Shandong University of Traditional Chinese MedicineFirst Clinical Medical College, Shandong University of Traditional Chinese MedicineFirst Clinical Medical College, Shandong University of Traditional Chinese MedicineFirst Clinical Medical College, Shandong University of Traditional Chinese MedicineDepartment of Geriatrics, Affiliated Hospital of Shandong University of Traditional Chinese MedicineAbstract Myocardial ischemia has the highest disease burden among all cardiovascular diseases making it a significant challenge to the global public health. It can result in myocardial cell damage and death due to impaired mitochondrial and endoplasmic reticulum (ER) functions. These two organelles are important regulators of cell death. In recent years, research has shifted from isolated studies of individual organelles to a more integrative approach, with a particular focus on their membrane contact sites—Mitochondria-Associated Endoplasmic Reticulum Membranes (MAMs). These dynamic microdomains play a crucial role in regulating material exchange and signal transduction between the endoplasmic reticulum and mitochondria. This review comprehensively describes the intricate structure of MAMs and their multifaceted roles in cellular pathophysiological processes. Particular focus was directed at the far-reaching effects of MAMs in regulating key pathological events including calcium homeostasis, mitochondrial dysfunction, ER stress, oxidative stress, and autophagy in ischemic heart disease (IHD). The potential treatment targets and regulatory mechanisms of MAMs were discussed and summarized, providing novel research directions and treatment approaches for improving myocardial ischemia-related diseases. Graphical Abstracthttps://doi.org/10.1186/s12967-025-06262-3Mitochondria-associated endoplasmic reticulum membranesMyocardial ischemiaCalcium homeostasisCellular stress |
| spellingShingle | Chen Chen Guohua Dai Maoxia Fan Xingmeng Wang Kaibin Niu Wulin Gao Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies Journal of Translational Medicine Mitochondria-associated endoplasmic reticulum membranes Myocardial ischemia Calcium homeostasis Cellular stress |
| title | Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies |
| title_full | Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies |
| title_fullStr | Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies |
| title_full_unstemmed | Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies |
| title_short | Mitochondria-associated endoplasmic reticulum membranes and myocardial ischemia: from molecular mechanisms to therapeutic strategies |
| title_sort | mitochondria associated endoplasmic reticulum membranes and myocardial ischemia from molecular mechanisms to therapeutic strategies |
| topic | Mitochondria-associated endoplasmic reticulum membranes Myocardial ischemia Calcium homeostasis Cellular stress |
| url | https://doi.org/10.1186/s12967-025-06262-3 |
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