Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma
Purpose. To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods. 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, an...
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| Format: | Article |
| Language: | English |
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Wiley
2017-01-01
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| Series: | Journal of Ophthalmology |
| Online Access: | http://dx.doi.org/10.1155/2017/2340236 |
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| author | Marta Gonzalez-Hernandez Jose Sigut Saavedra Manuel Gonzalez de la Rosa |
| author_facet | Marta Gonzalez-Hernandez Jose Sigut Saavedra Manuel Gonzalez de la Rosa |
| author_sort | Marta Gonzalez-Hernandez |
| collection | DOAJ |
| description | Purpose. To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods. 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). Results. The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R=0.81 (P<0.0001), similar to that between the BMO-MRW and BMO-RNFL thicknesses (R=0.85, P<0.0001) (P=0.227 between both R values). GDF correlated well with RNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The amount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses. The superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but without a clear RNFL topographic relationship. Conclusion. GDF showed high correlation with RNFL thickness. Except in the nasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness. |
| format | Article |
| id | doaj-art-92fe5267efc14bd49ac3d1f357e75b61 |
| institution | Kabale University |
| issn | 2090-004X 2090-0058 |
| language | English |
| publishDate | 2017-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Ophthalmology |
| spelling | doaj-art-92fe5267efc14bd49ac3d1f357e75b612025-08-20T03:37:23ZengWileyJournal of Ophthalmology2090-004X2090-00582017-01-01201710.1155/2017/23402362340236Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in GlaucomaMarta Gonzalez-Hernandez0Jose Sigut Saavedra1Manuel Gonzalez de la Rosa2Department of Ophthalmology, Hospital Universitario de Canarias, La Laguna, SpainDepartment of Systems Engineering, University of La Laguna, La Laguna, SpainDepartment of Ophthalmology, University of La Laguna, La Laguna, SpainPurpose. To observe the relationship between topographic hemoglobin levels in the optic nerve head (ONH), the rim thickness (BMO-MRW), and retinal nerve fiber layer (RNFL) thickness. Methods. 96 normal eyes and 82 glaucomas were examined using TOP strategy (Octopus 300 perimeter), SPECTRALIS OCT, and Laguna ONhE program which estimates hemoglobin from conventional color photographs (Horus Scope DEC 200 fundus camera). Results. The correlation between Laguna ONhE glaucoma discriminant function (GDF) and SPECTRALIS BMO-MRW was R=0.81 (P<0.0001), similar to that between the BMO-MRW and BMO-RNFL thicknesses (R=0.85, P<0.0001) (P=0.227 between both R values). GDF correlated well with RNFL thicknesses in the 360 degrees around the nerve, similar to mean perimetric sensitivity (MS) and BMO-MRW. The amount of hemoglobin in the nasal and temporal sectors showed low correlation with superior and inferior RNFL thicknesses. The superotemporal and inferotemporal sectors located on the vertical diameter of the disk showed good intercorrelation but without a clear RNFL topographic relationship. Conclusion. GDF showed high correlation with RNFL thickness. Except in the nasal and temporal sectors, ONH hemoglobin correlated well with RNFL thickness.http://dx.doi.org/10.1155/2017/2340236 |
| spellingShingle | Marta Gonzalez-Hernandez Jose Sigut Saavedra Manuel Gonzalez de la Rosa Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma Journal of Ophthalmology |
| title | Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma |
| title_full | Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma |
| title_fullStr | Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma |
| title_full_unstemmed | Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma |
| title_short | Relationship between Retinal Nerve Fiber Layer Thickness and Hemoglobin Present in the Optic Nerve Head in Glaucoma |
| title_sort | relationship between retinal nerve fiber layer thickness and hemoglobin present in the optic nerve head in glaucoma |
| url | http://dx.doi.org/10.1155/2017/2340236 |
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