HCV-related hepatocellular carcinoma: gene signatures associated with TERT promoter mutations and sex

HCV-related hepatocellular carcinoma: gene signatures associated with TERT promoter mutations and sex

Abstract Background Hepatocellular carcinoma (HCC) is a rapidly progressing disease, frequently caused by hepatitis C virus (HCV) infection and a higher prevalence in males than females. Over 60% of HCCs harbour frequent activating mutations in the telomerase reverse transcriptase promoter (TERTp)....

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Main Authors: Patrizia Bonelli, Anna Lucia Tornesello, Franca Maria Tuccillo, Noemy Starita, Andrea Cerasuolo, Tiziana Pecchillo Cimmino, Sara Amiranda, Francesco Izzo, Gerardo Ferrara, Luigi Buonaguro, Valli De Re, Franco Maria Buonaguro, Maria Lina Tornesello
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Journal of Translational Medicine
Subjects:
HCV
Gene signatures
TERT
Sex
Male
Female
Online Access:https://doi.org/10.1186/s12967-025-06560-w
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