Radiation therapy as a biological modifier of the breast cancer immune microenvironment
Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effec...
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-08-01
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| Series: | npj Breast Cancer |
| Online Access: | https://doi.org/10.1038/s41523-025-00801-3 |
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| _version_ | 1849342630512558080 |
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| author | Lorenzo Galluzzi Lukas Bolini Rebecca M. Shulman |
| author_facet | Lorenzo Galluzzi Lukas Bolini Rebecca M. Shulman |
| author_sort | Lorenzo Galluzzi |
| collection | DOAJ |
| description | Radiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment. |
| format | Article |
| id | doaj-art-92f46bfdffc8413eab2e848508f8cf56 |
| institution | Kabale University |
| issn | 2374-4677 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | npj Breast Cancer |
| spelling | doaj-art-92f46bfdffc8413eab2e848508f8cf562025-08-20T03:43:20ZengNature Portfolionpj Breast Cancer2374-46772025-08-011111310.1038/s41523-025-00801-3Radiation therapy as a biological modifier of the breast cancer immune microenvironmentLorenzo Galluzzi0Lukas Bolini1Rebecca M. Shulman2Cancer Signaling and Microenvironment Program, Fox Chase Cancer CenterCancer Signaling and Microenvironment Program, Fox Chase Cancer CenterDepartment of Radiation Oncology, Fox Chase Cancer CenterRadiotherapy has attracted considerable attention as a means to alter the immune cell compartment of breast malignancies in support of increased sensitivity to immunotherapy. Recent data from Schalck and colleagues corroborate the notion that dose is a critical determinant of the immunological effects of radiotherapy on the tumor microenvironment.https://doi.org/10.1038/s41523-025-00801-3 |
| spellingShingle | Lorenzo Galluzzi Lukas Bolini Rebecca M. Shulman Radiation therapy as a biological modifier of the breast cancer immune microenvironment npj Breast Cancer |
| title | Radiation therapy as a biological modifier of the breast cancer immune microenvironment |
| title_full | Radiation therapy as a biological modifier of the breast cancer immune microenvironment |
| title_fullStr | Radiation therapy as a biological modifier of the breast cancer immune microenvironment |
| title_full_unstemmed | Radiation therapy as a biological modifier of the breast cancer immune microenvironment |
| title_short | Radiation therapy as a biological modifier of the breast cancer immune microenvironment |
| title_sort | radiation therapy as a biological modifier of the breast cancer immune microenvironment |
| url | https://doi.org/10.1038/s41523-025-00801-3 |
| work_keys_str_mv | AT lorenzogalluzzi radiationtherapyasabiologicalmodifierofthebreastcancerimmunemicroenvironment AT lukasbolini radiationtherapyasabiologicalmodifierofthebreastcancerimmunemicroenvironment AT rebeccamshulman radiationtherapyasabiologicalmodifierofthebreastcancerimmunemicroenvironment |