History of Foreign Studies of Organophosphate Induced Delayed Neuropathy
Сertain organophosphates are highly toxic and can be used as chemical warfare agents. However, some classes of organic phosphorus compounds can cause so-called delayed neurotoxicity. Since the discovery of this phenomenon in 1899, extensive research has been conducted on delayed neurotoxicity caused...
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| Format: | Article |
| Language: | Russian |
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27 Scientific Centre named after academician N.D. Zelinsky
2020-06-01
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| Series: | Вестник войск РХБ защиты |
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| Online Access: | https://www.nbsprot.ru/jour/article/view/109 |
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| author | V. A. Inozemtsev I. A. Nelga I. V. Medvetsky S. A. Komissarenko A. V. Zlobin S. V. Tretyakov A. V. Sherstyuk |
| author_facet | V. A. Inozemtsev I. A. Nelga I. V. Medvetsky S. A. Komissarenko A. V. Zlobin S. V. Tretyakov A. V. Sherstyuk |
| author_sort | V. A. Inozemtsev |
| collection | DOAJ |
| description | Сertain organophosphates are highly toxic and can be used as chemical warfare agents. However, some classes of organic phosphorus compounds can cause so-called delayed neurotoxicity. Since the discovery of this phenomenon in 1899, extensive research has been conducted on delayed neurotoxicity caused by organophosphates. Mass poisoning of residents of the United States and Morocco in the last century demonstrated the high danger of substances that cause neurotoxicity, and gave a powerful impetus to research into this phenomenon. In addition to delayed effects, some phosphorus compounds potentiate the action of already known chemical warfare agents, increasing their toxicity by more than 10 times. Research in this direction is conducted under the auspices of the defense departments of the United States, Canada and the Netherlands. The wide distribution of phosphorus compounds in various industries and agriculture, the long hidden period and the irreversibility of lesions caused by neurotoxic organic phosphorus compounds, cause their potential threat to the security of the Russian Federation. |
| format | Article |
| id | doaj-art-92ec6315a8a84fce93c6bc1e3a191db9 |
| institution | Kabale University |
| issn | 2587-5728 |
| language | Russian |
| publishDate | 2020-06-01 |
| publisher | 27 Scientific Centre named after academician N.D. Zelinsky |
| record_format | Article |
| series | Вестник войск РХБ защиты |
| spelling | doaj-art-92ec6315a8a84fce93c6bc1e3a191db92025-08-20T03:59:31Zrus27 Scientific Centre named after academician N.D. ZelinskyВестник войск РХБ защиты2587-57282020-06-014217718810.35825/2587-5728-2020-4-2-177-188104History of Foreign Studies of Organophosphate Induced Delayed NeuropathyV. A. Inozemtsev0I. A. Nelga1I. V. Medvetsky2S. A. Komissarenko3A. V. Zlobin4S. V. Tretyakov5A. V. Sherstyuk6Federal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationFederal State Budgetary Establishment «33 Central Scientific Research Test Institute» of the Ministry of Defenсe of the Russian FederationСertain organophosphates are highly toxic and can be used as chemical warfare agents. However, some classes of organic phosphorus compounds can cause so-called delayed neurotoxicity. Since the discovery of this phenomenon in 1899, extensive research has been conducted on delayed neurotoxicity caused by organophosphates. Mass poisoning of residents of the United States and Morocco in the last century demonstrated the high danger of substances that cause neurotoxicity, and gave a powerful impetus to research into this phenomenon. In addition to delayed effects, some phosphorus compounds potentiate the action of already known chemical warfare agents, increasing their toxicity by more than 10 times. Research in this direction is conducted under the auspices of the defense departments of the United States, Canada and the Netherlands. The wide distribution of phosphorus compounds in various industries and agriculture, the long hidden period and the irreversibility of lesions caused by neurotoxic organic phosphorus compounds, cause their potential threat to the security of the Russian Federation.https://www.nbsprot.ru/jour/article/view/109neuropathy target esteraseorganic phosphorus compoundsdelayed neurotoxicitysynergismtri-ortho-cresyl phosphate |
| spellingShingle | V. A. Inozemtsev I. A. Nelga I. V. Medvetsky S. A. Komissarenko A. V. Zlobin S. V. Tretyakov A. V. Sherstyuk History of Foreign Studies of Organophosphate Induced Delayed Neuropathy Вестник войск РХБ защиты neuropathy target esterase organic phosphorus compounds delayed neurotoxicity synergism tri-ortho-cresyl phosphate |
| title | History of Foreign Studies of Organophosphate Induced Delayed Neuropathy |
| title_full | History of Foreign Studies of Organophosphate Induced Delayed Neuropathy |
| title_fullStr | History of Foreign Studies of Organophosphate Induced Delayed Neuropathy |
| title_full_unstemmed | History of Foreign Studies of Organophosphate Induced Delayed Neuropathy |
| title_short | History of Foreign Studies of Organophosphate Induced Delayed Neuropathy |
| title_sort | history of foreign studies of organophosphate induced delayed neuropathy |
| topic | neuropathy target esterase organic phosphorus compounds delayed neurotoxicity synergism tri-ortho-cresyl phosphate |
| url | https://www.nbsprot.ru/jour/article/view/109 |
| work_keys_str_mv | AT vainozemtsev historyofforeignstudiesoforganophosphateinduceddelayedneuropathy AT ianelga historyofforeignstudiesoforganophosphateinduceddelayedneuropathy AT ivmedvetsky historyofforeignstudiesoforganophosphateinduceddelayedneuropathy AT sakomissarenko historyofforeignstudiesoforganophosphateinduceddelayedneuropathy AT avzlobin historyofforeignstudiesoforganophosphateinduceddelayedneuropathy AT svtretyakov historyofforeignstudiesoforganophosphateinduceddelayedneuropathy AT avsherstyuk historyofforeignstudiesoforganophosphateinduceddelayedneuropathy |