Interactions between Bacteriophages and Eukaryotic Cells
As the name implies, bacteriophage is a bacterium-specific virus. It infects and kills the bacterial host. Bacteriophages have gained attention as alternative antimicrobial entities in the science community in the western world since the alarming rise of antibiotic resistance among microbes. Althoug...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2020-01-01
|
| Series: | Scientifica |
| Online Access: | http://dx.doi.org/10.1155/2020/3589316 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832566492391014400 |
|---|---|
| author | Ramendra Dirgantara Putra Diana Lyrawati |
| author_facet | Ramendra Dirgantara Putra Diana Lyrawati |
| author_sort | Ramendra Dirgantara Putra |
| collection | DOAJ |
| description | As the name implies, bacteriophage is a bacterium-specific virus. It infects and kills the bacterial host. Bacteriophages have gained attention as alternative antimicrobial entities in the science community in the western world since the alarming rise of antibiotic resistance among microbes. Although generally considered as prokaryote-specific viruses, recent studies indicate that bacteriophages can interact with eukaryotic organisms, including humans. In the current review, these interactions are divided into two categories, i.e., indirect and direct interactions, with the involvement of bacteriophages, bacteria, and eukaryotes. We discuss bacteriophage-related diseases, transcytosis of bacteriophages, bacteriophage interactions with cancer cells, collaboration of bacteriophages and eukaryotes against bacterial infections, and horizontal gene transfer between bacteriophages and eukaryotes. Such interactions are crucial for understanding and developing bacteriophages as the therapeutic agents and pharmaceutical delivery systems. With the advancement and combination of in silico, in vitro, and in vivo approaches and clinical trials, bacteriophages definitely serve as useful repertoire for biologic target-based drug development to manage many complex diseases in the future. |
| format | Article |
| id | doaj-art-92ea15edb84d4d6ab6954f9b08a02463 |
| institution | Kabale University |
| issn | 2090-908X |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Scientifica |
| spelling | doaj-art-92ea15edb84d4d6ab6954f9b08a024632025-02-03T01:03:59ZengWileyScientifica2090-908X2020-01-01202010.1155/2020/35893163589316Interactions between Bacteriophages and Eukaryotic CellsRamendra Dirgantara Putra0Diana Lyrawati1Department of Pharmacy, Faculty of Medicine, Brawijaya University, Malang 65145, IndonesiaDepartment of Pharmacy, Faculty of Medicine, Brawijaya University, Malang 65145, IndonesiaAs the name implies, bacteriophage is a bacterium-specific virus. It infects and kills the bacterial host. Bacteriophages have gained attention as alternative antimicrobial entities in the science community in the western world since the alarming rise of antibiotic resistance among microbes. Although generally considered as prokaryote-specific viruses, recent studies indicate that bacteriophages can interact with eukaryotic organisms, including humans. In the current review, these interactions are divided into two categories, i.e., indirect and direct interactions, with the involvement of bacteriophages, bacteria, and eukaryotes. We discuss bacteriophage-related diseases, transcytosis of bacteriophages, bacteriophage interactions with cancer cells, collaboration of bacteriophages and eukaryotes against bacterial infections, and horizontal gene transfer between bacteriophages and eukaryotes. Such interactions are crucial for understanding and developing bacteriophages as the therapeutic agents and pharmaceutical delivery systems. With the advancement and combination of in silico, in vitro, and in vivo approaches and clinical trials, bacteriophages definitely serve as useful repertoire for biologic target-based drug development to manage many complex diseases in the future.http://dx.doi.org/10.1155/2020/3589316 |
| spellingShingle | Ramendra Dirgantara Putra Diana Lyrawati Interactions between Bacteriophages and Eukaryotic Cells Scientifica |
| title | Interactions between Bacteriophages and Eukaryotic Cells |
| title_full | Interactions between Bacteriophages and Eukaryotic Cells |
| title_fullStr | Interactions between Bacteriophages and Eukaryotic Cells |
| title_full_unstemmed | Interactions between Bacteriophages and Eukaryotic Cells |
| title_short | Interactions between Bacteriophages and Eukaryotic Cells |
| title_sort | interactions between bacteriophages and eukaryotic cells |
| url | http://dx.doi.org/10.1155/2020/3589316 |
| work_keys_str_mv | AT ramendradirgantaraputra interactionsbetweenbacteriophagesandeukaryoticcells AT dianalyrawati interactionsbetweenbacteriophagesandeukaryoticcells |