Molecular Profiling of Endometrial Malignancies
Molecular profiling of endometrial neoplasms reveals genetic changes in endometrial carcinomas that support the dualistic model, in which type I carcinomas are estrogen-dependent, low grade lesions and type II carcinomas are nonestrogen dependent and high grade. The molecular changes in type I endo...
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| Format: | Article |
| Language: | English |
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Wiley
2010-01-01
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| Series: | Obstetrics and Gynecology International |
| Online Access: | http://dx.doi.org/10.1155/2010/162363 |
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| author | Norasate Samarnthai Kevin Hall I-Tien Yeh |
| author_facet | Norasate Samarnthai Kevin Hall I-Tien Yeh |
| author_sort | Norasate Samarnthai |
| collection | DOAJ |
| description | Molecular profiling of endometrial neoplasms reveals genetic changes in endometrial carcinomas that support the dualistic model, in which type I carcinomas are estrogen-dependent, low grade lesions and type II carcinomas are nonestrogen dependent and high grade. The molecular changes in type I endometrial carcinomas include mutations in PTEN, PIK3CA, KRAS, and 𝛽-catenin, along with microsatellite instability, whereas type II endometrial carcinomas are characterized by genetic alterations in p53, HER2/neu, p16, and E-cadherin. For endometrial neoplasms with a malignant mesenchymal component, C-MYC mutations and loss of heterozygosity are frequently seen in carcinosarcomas, and a fusion gene, JAZF1/JJAZ1, is distinctive for endometrial stromal sarcoma. In addition, p53 mutations may play an important role in tumorigenesis of undifferentiated endometrial sarcoma. These molecular changes can help in the diagnosis of endometrial neoplasms, as well as form the basis of molecular targeted therapy. |
| format | Article |
| id | doaj-art-92e79356d1c64041bf0bf3cd863ae434 |
| institution | Kabale University |
| issn | 1687-9589 1687-9597 |
| language | English |
| publishDate | 2010-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Obstetrics and Gynecology International |
| spelling | doaj-art-92e79356d1c64041bf0bf3cd863ae4342025-08-20T03:37:23ZengWileyObstetrics and Gynecology International1687-95891687-95972010-01-01201010.1155/2010/162363162363Molecular Profiling of Endometrial MalignanciesNorasate Samarnthai0Kevin Hall1I-Tien Yeh2Department of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USADepartment of Obstetrics and Gynecology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USADepartment of Pathology, University of Texas Health Science Center at San Antonio, San Antonio, TX 78229, USAMolecular profiling of endometrial neoplasms reveals genetic changes in endometrial carcinomas that support the dualistic model, in which type I carcinomas are estrogen-dependent, low grade lesions and type II carcinomas are nonestrogen dependent and high grade. The molecular changes in type I endometrial carcinomas include mutations in PTEN, PIK3CA, KRAS, and 𝛽-catenin, along with microsatellite instability, whereas type II endometrial carcinomas are characterized by genetic alterations in p53, HER2/neu, p16, and E-cadherin. For endometrial neoplasms with a malignant mesenchymal component, C-MYC mutations and loss of heterozygosity are frequently seen in carcinosarcomas, and a fusion gene, JAZF1/JJAZ1, is distinctive for endometrial stromal sarcoma. In addition, p53 mutations may play an important role in tumorigenesis of undifferentiated endometrial sarcoma. These molecular changes can help in the diagnosis of endometrial neoplasms, as well as form the basis of molecular targeted therapy.http://dx.doi.org/10.1155/2010/162363 |
| spellingShingle | Norasate Samarnthai Kevin Hall I-Tien Yeh Molecular Profiling of Endometrial Malignancies Obstetrics and Gynecology International |
| title | Molecular Profiling of Endometrial Malignancies |
| title_full | Molecular Profiling of Endometrial Malignancies |
| title_fullStr | Molecular Profiling of Endometrial Malignancies |
| title_full_unstemmed | Molecular Profiling of Endometrial Malignancies |
| title_short | Molecular Profiling of Endometrial Malignancies |
| title_sort | molecular profiling of endometrial malignancies |
| url | http://dx.doi.org/10.1155/2010/162363 |
| work_keys_str_mv | AT norasatesamarnthai molecularprofilingofendometrialmalignancies AT kevinhall molecularprofilingofendometrialmalignancies AT itienyeh molecularprofilingofendometrialmalignancies |