Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation

Dynamic properties of transcriptional condensates modulate CRISPRa-mediated gene activation

Abstract CRISPR activation (CRISPRa) is a powerful tool for endogenous gene activation, yet the mechanisms underlying its optimal transcriptional activation remain unclear. By monitoring real-time transcriptional bursts, we find that CRISPRa modulates both burst duration and amplitude. Our quantitat...

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Main Authors: Yujuan Fu, Xiaoxuan Yang, Sihui Li, Chenyang Ma, Yao An, Tao Cheng, Ying Liang, Shengbai Sun, Tianyi Cheng, Yongyang Zhao, Jianghu Wang, Xiaoyue Wang, Pengfei Xu, Yafei Yin, Hongqing Liang, Nan Liu, Wei Zou, Baohui Chen
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-56735-8
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