Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks
Simeng Wei,1– 3,* Bingbing Chen,1– 3,* Zhenglong Guo,1– 3 Haoxiang Zhang,1– 3 Jianying Li,1,2 Xiaodong Hu,1,2 Chunxia Yang,1,2 Jianhong Li,1,2 Xinrong Li,1,2 Zhifen Liu,1,2 Yong Xu,1 Sha Liu1– 3 1Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medica...
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Dove Medical Press
2025-02-01
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| Series: | Neuropsychiatric Disease and Treatment |
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| author | Wei S Chen B Guo Z Zhang H Li J Hu X Yang C Li J Li X Liu Z Xu Y Liu S |
| author_facet | Wei S Chen B Guo Z Zhang H Li J Hu X Yang C Li J Li X Liu Z Xu Y Liu S |
| author_sort | Wei S |
| collection | DOAJ |
| description | Simeng Wei,1– 3,* Bingbing Chen,1– 3,* Zhenglong Guo,1– 3 Haoxiang Zhang,1– 3 Jianying Li,1,2 Xiaodong Hu,1,2 Chunxia Yang,1,2 Jianhong Li,1,2 Xinrong Li,1,2 Zhifen Liu,1,2 Yong Xu,1 Sha Liu1– 3 1Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 2Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 3Shanxi Medical University, Taiyuan, 030001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sha Liu; Yong Xu, Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan, SX030001, People’s Republic of China, Tel +8615803400167, Email liusha@sxmu.edu.cn; xuyongsmu@vip.163.comBackground: Magnetic Seizure Therapy (MST) is an emerging psychiatric physical therapy in recent years, and the MST technique induces seizures by stimulating the local cortex. Numerous studies have shown that compared to electroconvulsive therapy (ECT), magnetic shock therapy (MST) has relatively little effect on cognitive function, and thus has certain advantages in clinical application. However, as far as magnetic shock therapy itself is concerned, there are few studies specifically focusing on its efficacy in depth, and the mechanism of MST in treating schizophrenia is still unclear.Methods: This study centered on the key question of “the efficacy of magnetic stunning therapy for patients with schizophrenia and the combined fMRI-EEG to explore the regulatory mechanisms of brain networks”. The study protocol describes our interventional clinical trial aimed at developing magnetic convulsive therapy as an effective and safe treatment for SCZ. The study population consisted of SCZ patients and healthy controls (Hc). Clinical symptoms, cognitive function, EEG and fMRI data were collected from the patient group at baseline, post-treatment and follow-up phases. We systematically assessed the clinical features and cognitive functions of the patients, combined with EEG and fMRI indexes to explore the brain network connectivity abnormalities in SCZ patients, and jointly explored the neuroimaging mechanisms in SCZ patients.Conclusion: Positive results from this trial may have a direct and significant impact on patients with SCZ. Once the MST demonstrates significant antipsychotic efficacy with high perceived safety, it will have significant implications for clinical practice. Brain network abnormality may be one of the core pathological mechanisms of SCZ. Therefore, by combining neurophysiological imaging techniques to scientifically verify the abnormality of SCZ brain network, the elucidation of this issue can help to further reveal the pathological mechanism of SCZ and provide a scientific basis for the effective and precise treatment of the disease.Trial Registration: ChiCTR2000038361 Registered on September 21, 2020.Keywords: Schizophrenia, Magnetic Seizure Therapy, Electroencephalogram, Functional Magnetic Resonance Imaging |
| format | Article |
| id | doaj-art-92e57182d3e24ef1a504855a3e4721b1 |
| institution | DOAJ |
| issn | 1178-2021 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Neuropsychiatric Disease and Treatment |
| spelling | doaj-art-92e57182d3e24ef1a504855a3e4721b12025-08-20T03:00:51ZengDove Medical PressNeuropsychiatric Disease and Treatment1178-20212025-02-01Volume 21323334100362Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain NetworksWei SChen BGuo ZZhang HLi JHu XYang CLi JLi XLiu ZXu YLiu SSimeng Wei,1– 3,* Bingbing Chen,1– 3,* Zhenglong Guo,1– 3 Haoxiang Zhang,1– 3 Jianying Li,1,2 Xiaodong Hu,1,2 Chunxia Yang,1,2 Jianhong Li,1,2 Xinrong Li,1,2 Zhifen Liu,1,2 Yong Xu,1 Sha Liu1– 3 1Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 2Shanxi Key Laboratory of Artificial Intelligence Assisted Diagnosis and Treatment for Mental Disorder, First Hospital of Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 3Shanxi Medical University, Taiyuan, 030001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Sha Liu; Yong Xu, Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, No. 85 Jiefang South Road, Taiyuan, SX030001, People’s Republic of China, Tel +8615803400167, Email liusha@sxmu.edu.cn; xuyongsmu@vip.163.comBackground: Magnetic Seizure Therapy (MST) is an emerging psychiatric physical therapy in recent years, and the MST technique induces seizures by stimulating the local cortex. Numerous studies have shown that compared to electroconvulsive therapy (ECT), magnetic shock therapy (MST) has relatively little effect on cognitive function, and thus has certain advantages in clinical application. However, as far as magnetic shock therapy itself is concerned, there are few studies specifically focusing on its efficacy in depth, and the mechanism of MST in treating schizophrenia is still unclear.Methods: This study centered on the key question of “the efficacy of magnetic stunning therapy for patients with schizophrenia and the combined fMRI-EEG to explore the regulatory mechanisms of brain networks”. The study protocol describes our interventional clinical trial aimed at developing magnetic convulsive therapy as an effective and safe treatment for SCZ. The study population consisted of SCZ patients and healthy controls (Hc). Clinical symptoms, cognitive function, EEG and fMRI data were collected from the patient group at baseline, post-treatment and follow-up phases. We systematically assessed the clinical features and cognitive functions of the patients, combined with EEG and fMRI indexes to explore the brain network connectivity abnormalities in SCZ patients, and jointly explored the neuroimaging mechanisms in SCZ patients.Conclusion: Positive results from this trial may have a direct and significant impact on patients with SCZ. Once the MST demonstrates significant antipsychotic efficacy with high perceived safety, it will have significant implications for clinical practice. Brain network abnormality may be one of the core pathological mechanisms of SCZ. Therefore, by combining neurophysiological imaging techniques to scientifically verify the abnormality of SCZ brain network, the elucidation of this issue can help to further reveal the pathological mechanism of SCZ and provide a scientific basis for the effective and precise treatment of the disease.Trial Registration: ChiCTR2000038361 Registered on September 21, 2020.Keywords: Schizophrenia, Magnetic Seizure Therapy, Electroencephalogram, Functional Magnetic Resonance Imaginghttps://www.dovepress.com/efficacy-of-magnetic-seizure-therapy-in-patients-with-schizophrenia-an-peer-reviewed-fulltext-article-NDTschizophreniamagnetic seizure therapyelectroencephalogramfunctional magnetic resonance imaging |
| spellingShingle | Wei S Chen B Guo Z Zhang H Li J Hu X Yang C Li J Li X Liu Z Xu Y Liu S Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks Neuropsychiatric Disease and Treatment schizophrenia magnetic seizure therapy electroencephalogram functional magnetic resonance imaging |
| title | Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks |
| title_full | Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks |
| title_fullStr | Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks |
| title_full_unstemmed | Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks |
| title_short | Efficacy of Magnetic Seizure Therapy in Patients with Schizophrenia and Combined fMRI-EEG to Explore the Regulatory Mechanisms of Brain Networks |
| title_sort | efficacy of magnetic seizure therapy in patients with schizophrenia and combined fmri eeg to explore the regulatory mechanisms of brain networks |
| topic | schizophrenia magnetic seizure therapy electroencephalogram functional magnetic resonance imaging |
| url | https://www.dovepress.com/efficacy-of-magnetic-seizure-therapy-in-patients-with-schizophrenia-an-peer-reviewed-fulltext-article-NDT |
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