“The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients”
Abstract Mini-abstract The aim of the current study was to examine the effects of light- to moderate intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using bone formation and resorption markers. In the current study, P1NP and CTX levels increased in both...
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BMC
2025-04-01
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| Series: | BMC Musculoskeletal Disorders |
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| Online Access: | https://doi.org/10.1186/s12891-025-08578-z |
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| author | Kübra Nur Deniz Meliha Kasapoğlu Aksoy |
| author_facet | Kübra Nur Deniz Meliha Kasapoğlu Aksoy |
| author_sort | Kübra Nur Deniz |
| collection | DOAJ |
| description | Abstract Mini-abstract The aim of the current study was to examine the effects of light- to moderate intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using bone formation and resorption markers. In the current study, P1NP and CTX levels increased in both the exercise and the control group. Summary The aim of the current study was to examine the effects of light- to moderate-intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using rapidly responsive bone formation and resorption markers. Purpose In this prospective, randomized, controlled, single-blind clinical study, women aged 45–65 years with BMD T scores between − 1 and − 2.5 measured by double X-ray absorptiometry (DXA) were included after evaluation of exclusion criteria and the women were divided into 2 groups: aerobic exercise group and control group (exercise, n = 25; control, n = 25). At baseline and at the 12-week follow-up, the serum levels of bone formation and resorption biomarkers, including procollagen type 1 N-terminal propeptide (P1NP), cross-linked C-telopeptide of type I collagen (CTX), osteocalcin, oxidative markers such as malondialdehyde, nonbone-specific total alkaline phosphatase, 25(OH)D3, and parathyroid hormone (PTH), were examined in all patients. Results A statistically significant increase in P1NP and CTX levels was noted in both the exercise and control groups at the 12-week evaluation compared to baseline (p > 0.05). Although there was no significant change in osteocalcin levels in the control group (p > 0.05), a statistically significant increase was observed in the exercise group (p < 0.05). In the exercise group, no significant changes were observed in bone formation or resorption markers, including P1NP, CTX, osteocalcin, and total ALP, or in oxidative stress markers, such as malondialdehyde, compared to those in the control group (p > 0.05). Conclusion In conclusion, the current study revealed that regular walking exercise of light to moderate intensity significantly contributes to improvements in pain, walking speed, balance, lower extremity dynamic balance, and activities of daily living in postmenopausal women with osteopenia compared to inactive individuals. Trial registration Clinical Trial Number NCT06866561. |
| format | Article |
| id | doaj-art-92e4c55691044fa8b48686afb6a4035b |
| institution | DOAJ |
| issn | 1471-2474 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Musculoskeletal Disorders |
| spelling | doaj-art-92e4c55691044fa8b48686afb6a4035b2025-08-20T03:14:08ZengBMCBMC Musculoskeletal Disorders1471-24742025-04-0126111010.1186/s12891-025-08578-z“The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients”Kübra Nur Deniz0Meliha Kasapoğlu Aksoy1Department of Physical Medicine and Rehabilitation, Varto Public HospitalDepartment of Physical Medicine and Rehabilitation, University of Health Sciences Bursa Yüksek Ihtisas Training and Research HospitalAbstract Mini-abstract The aim of the current study was to examine the effects of light- to moderate intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using bone formation and resorption markers. In the current study, P1NP and CTX levels increased in both the exercise and the control group. Summary The aim of the current study was to examine the effects of light- to moderate-intensity aerobic exercise on bone mineral density (BMD) in postmenopausal osteopenic women by using rapidly responsive bone formation and resorption markers. Purpose In this prospective, randomized, controlled, single-blind clinical study, women aged 45–65 years with BMD T scores between − 1 and − 2.5 measured by double X-ray absorptiometry (DXA) were included after evaluation of exclusion criteria and the women were divided into 2 groups: aerobic exercise group and control group (exercise, n = 25; control, n = 25). At baseline and at the 12-week follow-up, the serum levels of bone formation and resorption biomarkers, including procollagen type 1 N-terminal propeptide (P1NP), cross-linked C-telopeptide of type I collagen (CTX), osteocalcin, oxidative markers such as malondialdehyde, nonbone-specific total alkaline phosphatase, 25(OH)D3, and parathyroid hormone (PTH), were examined in all patients. Results A statistically significant increase in P1NP and CTX levels was noted in both the exercise and control groups at the 12-week evaluation compared to baseline (p > 0.05). Although there was no significant change in osteocalcin levels in the control group (p > 0.05), a statistically significant increase was observed in the exercise group (p < 0.05). In the exercise group, no significant changes were observed in bone formation or resorption markers, including P1NP, CTX, osteocalcin, and total ALP, or in oxidative stress markers, such as malondialdehyde, compared to those in the control group (p > 0.05). Conclusion In conclusion, the current study revealed that regular walking exercise of light to moderate intensity significantly contributes to improvements in pain, walking speed, balance, lower extremity dynamic balance, and activities of daily living in postmenopausal women with osteopenia compared to inactive individuals. Trial registration Clinical Trial Number NCT06866561.https://doi.org/10.1186/s12891-025-08578-zPostmenopausal osteoporosisP1NPCTXExerciseOsteocalsinMalondialdehyde |
| spellingShingle | Kübra Nur Deniz Meliha Kasapoğlu Aksoy “The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients” BMC Musculoskeletal Disorders Postmenopausal osteoporosis P1NP CTX Exercise Osteocalsin Malondialdehyde |
| title | “The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients” |
| title_full | “The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients” |
| title_fullStr | “The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients” |
| title_full_unstemmed | “The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients” |
| title_short | “The effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients” |
| title_sort | the effect of aerobic exercise on bone formation and resorption markers and the quality of life tests in postmenopausal osteopenic patients |
| topic | Postmenopausal osteoporosis P1NP CTX Exercise Osteocalsin Malondialdehyde |
| url | https://doi.org/10.1186/s12891-025-08578-z |
| work_keys_str_mv | AT kubranurdeniz theeffectofaerobicexerciseonboneformationandresorptionmarkersandthequalityoflifetestsinpostmenopausalosteopenicpatients AT melihakasapogluaksoy theeffectofaerobicexerciseonboneformationandresorptionmarkersandthequalityoflifetestsinpostmenopausalosteopenicpatients |