Molecular cytogenetics for acute megakaryocytic leukemia diagnosis
Acute megakaryocytic leukemia (AML M7) – a rare disease characterized by poor treatment response, except for t(1;22) variant in infants. Cytogenetic abnormalities in AML M7 are highly heterogeneous. We collected samples from children with AML M7 to analyze the disease cytogenetic profile. During Sep...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2014-07-01
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| Series: | Онкогематология |
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| Online Access: | https://oncohematology.abvpress.ru/ongm/article/view/62 |
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| author | E. A. Matveeva A. N. Kazakova I. I. Kalinina M. E. Dubrovina L. V. Baydun M. A. Maschan Yu. V. Olshanskaya A. A. Maschan |
| author_facet | E. A. Matveeva A. N. Kazakova I. I. Kalinina M. E. Dubrovina L. V. Baydun M. A. Maschan Yu. V. Olshanskaya A. A. Maschan |
| author_sort | E. A. Matveeva |
| collection | DOAJ |
| description | Acute megakaryocytic leukemia (AML M7) – a rare disease characterized by poor treatment response, except for t(1;22) variant in infants. Cytogenetic abnormalities in AML M7 are highly heterogeneous. We collected samples from children with AML M7 to analyze the disease cytogenetic profile. During September 2009 to March 2012 20 AML M7 patients was studied using fluorescence in situ hybridization. Complex and heterogeneous chromosomal abnormalities were revealed. It was found that no recurring abnormalities and cytogenetic markers unique to each patients. Also, the 19p13 amplification described previously only in myeloid cell lines was detected. |
| format | Article |
| id | doaj-art-92e35b4d58d44e278429396a569dfd8f |
| institution | Kabale University |
| issn | 1818-8346 2413-4023 |
| language | Russian |
| publishDate | 2014-07-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Онкогематология |
| spelling | doaj-art-92e35b4d58d44e278429396a569dfd8f2025-08-20T03:35:33ZrusABV-pressОнкогематология1818-83462413-40232014-07-0172515610.17650/1818-8346-2012-7-2-51-5677Molecular cytogenetics for acute megakaryocytic leukemia diagnosisE. A. Matveeva0A. N. Kazakova1I. I. Kalinina2M. E. Dubrovina3L. V. Baydun4M. A. Maschan5Yu. V. Olshanskaya6A. A. Maschan7D. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyD. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyD. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyD. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyRussian Children Clinical HospitalD. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyD. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyD. Rogachev Federal Research Center of Pediatric Hematology, Oncology and ImmunologyAcute megakaryocytic leukemia (AML M7) – a rare disease characterized by poor treatment response, except for t(1;22) variant in infants. Cytogenetic abnormalities in AML M7 are highly heterogeneous. We collected samples from children with AML M7 to analyze the disease cytogenetic profile. During September 2009 to March 2012 20 AML M7 patients was studied using fluorescence in situ hybridization. Complex and heterogeneous chromosomal abnormalities were revealed. It was found that no recurring abnormalities and cytogenetic markers unique to each patients. Also, the 19p13 amplification described previously only in myeloid cell lines was detected.https://oncohematology.abvpress.ru/ongm/article/view/62acute megakaryocytic leukemiafishamplificationchildren |
| spellingShingle | E. A. Matveeva A. N. Kazakova I. I. Kalinina M. E. Dubrovina L. V. Baydun M. A. Maschan Yu. V. Olshanskaya A. A. Maschan Molecular cytogenetics for acute megakaryocytic leukemia diagnosis Онкогематология acute megakaryocytic leukemia fish amplification children |
| title | Molecular cytogenetics for acute megakaryocytic leukemia diagnosis |
| title_full | Molecular cytogenetics for acute megakaryocytic leukemia diagnosis |
| title_fullStr | Molecular cytogenetics for acute megakaryocytic leukemia diagnosis |
| title_full_unstemmed | Molecular cytogenetics for acute megakaryocytic leukemia diagnosis |
| title_short | Molecular cytogenetics for acute megakaryocytic leukemia diagnosis |
| title_sort | molecular cytogenetics for acute megakaryocytic leukemia diagnosis |
| topic | acute megakaryocytic leukemia fish amplification children |
| url | https://oncohematology.abvpress.ru/ongm/article/view/62 |
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