Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response

Selective epithelial expression of KRASG12D in the Oncopig pancreas drives ductal proliferation and desmoplasia that is accompanied by an immune response

Abstract Pancreatic ductal adenocarcinoma (PDAC) remains a formidable challenge in oncology, characterized by a high mortality rate, largely attributable to delayed diagnosis and the intricacies of its tumor microenvironment. Innovations in modeling pancreatic epithelial transformation provide valua...

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Bibliographic Details
Main Authors: Carlos P. Jara, Al-Murtadha Al-Gahmi, Audrey Lazenby, Michael A. Hollingsworth, Mark A. Carlson
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
PDAC
Ad-K8-Cre
Oncopigs
Neoplasia
Desmoplastic reaction
KRASG12D
Online Access:https://doi.org/10.1038/s41598-025-87178-2
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