Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease
ABSTRACT Background Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear. Objective The objective of this study was to investigate the likelihood of a relapse occurring at the same si...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2025-03-01
|
| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.70127 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849764134358351872 |
|---|---|
| author | Daniel Lordelo San Martin Marcos Baruch Portela Filho Chiara Rocchi Shahd Hamid Saif Huda |
| author_facet | Daniel Lordelo San Martin Marcos Baruch Portela Filho Chiara Rocchi Shahd Hamid Saif Huda |
| author_sort | Daniel Lordelo San Martin |
| collection | DOAJ |
| description | ABSTRACT Background Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear. Objective The objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD. Methods This was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow‐up were included. To identify factors associated with relapse location, logistic regression was performed. Results An increased risk of a relapse in the same location was observed when the first attack was optic neuritis—for the second attack (OR 12.9, 95% CI 3.31–50.55, p = .001) and all subsequent attacks (OR 5.39 95% CI 1.61–18.03, p = .006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis—for the second attack (OR 0.25, 95% CI 0.07–0.82, p = .022) and all subsequent attacks (OR 0.25 95% CI 0.06–0.96, p = .045). Conclusion In relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk. |
| format | Article |
| id | doaj-art-92d6c908bdf84fc78e856bdbf5abc59e |
| institution | DOAJ |
| issn | 2162-3279 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj-art-92d6c908bdf84fc78e856bdbf5abc59e2025-08-20T03:05:14ZengWileyBrain and Behavior2162-32792025-03-01153n/an/a10.1002/brb3.70127Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated DiseaseDaniel Lordelo San Martin0Marcos Baruch Portela Filho1Chiara Rocchi2Shahd Hamid3Saif Huda4NMOSD National Service Walton Centre Foundation Trust Liverpool UKDeparment of Life Science State University of Bahia Salvador BrazilNMOSD National Service Walton Centre Foundation Trust Liverpool UKNMOSD National Service Walton Centre Foundation Trust Liverpool UKNMOSD National Service Walton Centre Foundation Trust Liverpool UKABSTRACT Background Studies in MS and NMOSD have shown that relapses can frequently occur in the same location as the first attack. Factors associated with this outcome in MOGAD are unclear. Objective The objective of this study was to investigate the likelihood of a relapse occurring at the same site in MOGAD. Methods This was a UK national cohort study. MOGAD patients with a minimum of one relapse and one year of follow‐up were included. To identify factors associated with relapse location, logistic regression was performed. Results An increased risk of a relapse in the same location was observed when the first attack was optic neuritis—for the second attack (OR 12.9, 95% CI 3.31–50.55, p = .001) and all subsequent attacks (OR 5.39 95% CI 1.61–18.03, p = .006). Conversely, a reduced risk of relapse in the same location was associated with transverse myelitis—for the second attack (OR 0.25, 95% CI 0.07–0.82, p = .022) and all subsequent attacks (OR 0.25 95% CI 0.06–0.96, p = .045). Conclusion In relapsing MOGAD, patients with optic neuritis are at high risk of a new attack in the same location, while those with transverse myelitis are at low risk.https://doi.org/10.1002/brb3.70127brainbrainstem/cerebellummyelin oligodendrocyte glycoprotein antibody‐associated diseasemyelitisoptic neuritisrelapse |
| spellingShingle | Daniel Lordelo San Martin Marcos Baruch Portela Filho Chiara Rocchi Shahd Hamid Saif Huda Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease Brain and Behavior brain brainstem/cerebellum myelin oligodendrocyte glycoprotein antibody‐associated disease myelitis optic neuritis relapse |
| title | Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease |
| title_full | Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease |
| title_fullStr | Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease |
| title_full_unstemmed | Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease |
| title_short | Opposing Influences of Optic Neuritis and Transverse Myelitis on the Future Location of Relapses in MOG Antibody–Associated Disease |
| title_sort | opposing influences of optic neuritis and transverse myelitis on the future location of relapses in mog antibody associated disease |
| topic | brain brainstem/cerebellum myelin oligodendrocyte glycoprotein antibody‐associated disease myelitis optic neuritis relapse |
| url | https://doi.org/10.1002/brb3.70127 |
| work_keys_str_mv | AT daniellordelosanmartin opposinginfluencesofopticneuritisandtransversemyelitisonthefuturelocationofrelapsesinmogantibodyassociateddisease AT marcosbaruchportelafilho opposinginfluencesofopticneuritisandtransversemyelitisonthefuturelocationofrelapsesinmogantibodyassociateddisease AT chiararocchi opposinginfluencesofopticneuritisandtransversemyelitisonthefuturelocationofrelapsesinmogantibodyassociateddisease AT shahdhamid opposinginfluencesofopticneuritisandtransversemyelitisonthefuturelocationofrelapsesinmogantibodyassociateddisease AT saifhuda opposinginfluencesofopticneuritisandtransversemyelitisonthefuturelocationofrelapsesinmogantibodyassociateddisease |