Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis
Abstract Objectives The research aimed to provide the most recent and comprehensive analysis and evidence update comparing outcomes in neonatal encephalopathy (NE) based on different glycemia levels. Patients and methods A comprehensive search of Cochrane, PubMed, Embase, Web of Science, CNKI, and W...
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BMC
2024-11-01
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| Series: | BMC Pediatrics |
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| Online Access: | https://doi.org/10.1186/s12887-024-05176-1 |
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| author | Chen Wang Haiyin Jiang Ji Wu Zhenxi Yu Qiutong Li Chun-Ming Jiang |
| author_facet | Chen Wang Haiyin Jiang Ji Wu Zhenxi Yu Qiutong Li Chun-Ming Jiang |
| author_sort | Chen Wang |
| collection | DOAJ |
| description | Abstract Objectives The research aimed to provide the most recent and comprehensive analysis and evidence update comparing outcomes in neonatal encephalopathy (NE) based on different glycemia levels. Patients and methods A comprehensive search of Cochrane, PubMed, Embase, Web of Science, CNKI, and Wanfang databases was conducted until September 2023. The purpose was to identify research that examined the effects of hyperglycemia, hypoglycemia, and normoglycemia on NE outcomes. The hyperglycemic, normoglycemic and hypoglycemic group were compared. Outcomes measured were mortality, abnormal MRI, hearing or visual unfavorable outcomes, neurodevelopmental delay, cerebral palsy, and all unfavorable outcomes. Results Thirteen literatures comprising 2,427 participants (1,233 with normoglycemia, 835 with hyperglycemia, and 359 with hypoglycemia) were considered. Pooled analysis showed more overall adverse outcomes, higher mortality and worse hearing or visual outcomes in the hyperglycemic and hypoglycemic group compared to the normoglycemic group. There was no notable distinction found in abnormal MRI and cerebral palsy among all groups. The hypoglycemic group exhibited greater neurodevelopmental delay than normoglycemia. Conclusions Maintaining normal blood glucose levels in neonates with NE can help reduce the risk of adverse consequences such as hearing and visual impairment. |
| format | Article |
| id | doaj-art-92cfb340a17b4acd84789222d070aaa4 |
| institution | DOAJ |
| issn | 1471-2431 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | BMC |
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| series | BMC Pediatrics |
| spelling | doaj-art-92cfb340a17b4acd84789222d070aaa42025-08-20T02:50:08ZengBMCBMC Pediatrics1471-24312024-11-0124111710.1186/s12887-024-05176-1Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysisChen Wang0Haiyin Jiang1Ji Wu2Zhenxi Yu3Qiutong Li4Chun-Ming Jiang5The Fourth School of Clinical Medicine, Zhejiang Chinese Medical UniversityZhejiang University School of MedicineThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical UniversityDepartment of Pediatrics, Affiliated Hangzhou First People’s Hospital, Westlake University School of MedicineThe Fourth School of Clinical Medicine, Zhejiang Chinese Medical UniversityDepartment of Pediatrics, Affiliated Hangzhou First People’s Hospital, Westlake University School of MedicineAbstract Objectives The research aimed to provide the most recent and comprehensive analysis and evidence update comparing outcomes in neonatal encephalopathy (NE) based on different glycemia levels. Patients and methods A comprehensive search of Cochrane, PubMed, Embase, Web of Science, CNKI, and Wanfang databases was conducted until September 2023. The purpose was to identify research that examined the effects of hyperglycemia, hypoglycemia, and normoglycemia on NE outcomes. The hyperglycemic, normoglycemic and hypoglycemic group were compared. Outcomes measured were mortality, abnormal MRI, hearing or visual unfavorable outcomes, neurodevelopmental delay, cerebral palsy, and all unfavorable outcomes. Results Thirteen literatures comprising 2,427 participants (1,233 with normoglycemia, 835 with hyperglycemia, and 359 with hypoglycemia) were considered. Pooled analysis showed more overall adverse outcomes, higher mortality and worse hearing or visual outcomes in the hyperglycemic and hypoglycemic group compared to the normoglycemic group. There was no notable distinction found in abnormal MRI and cerebral palsy among all groups. The hypoglycemic group exhibited greater neurodevelopmental delay than normoglycemia. Conclusions Maintaining normal blood glucose levels in neonates with NE can help reduce the risk of adverse consequences such as hearing and visual impairment.https://doi.org/10.1186/s12887-024-05176-1NeonateHypoglycemiaHypoxia-ischemia |
| spellingShingle | Chen Wang Haiyin Jiang Ji Wu Zhenxi Yu Qiutong Li Chun-Ming Jiang Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis BMC Pediatrics Neonate Hypoglycemia Hypoxia-ischemia |
| title | Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis |
| title_full | Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis |
| title_fullStr | Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis |
| title_full_unstemmed | Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis |
| title_short | Association between glycemia and outcomes of neonates with hypoxic-ischemic encephalopathy: a systematic review and meta-analysis |
| title_sort | association between glycemia and outcomes of neonates with hypoxic ischemic encephalopathy a systematic review and meta analysis |
| topic | Neonate Hypoglycemia Hypoxia-ischemia |
| url | https://doi.org/10.1186/s12887-024-05176-1 |
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