F18-FLT PET/CT in Patients with Gastric Carcinoma
The aim of the study was to evaluate the usefulness of 18F-FLT PET/CT in the detection and differentiation of gastric cancers (GC). 104 consecutive patients (57 cases of adenocarcinoma tubulare (G2 and G3), 17 cases of mucinous adenocarcinoma, 6 cases of undifferentiated carcinoma, 14 cases of adeno...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Gastroenterology Research and Practice |
| Online Access: | http://dx.doi.org/10.1155/2013/696423 |
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| author | Bogdan Małkowski Tomasz Staniuk Ewa Śrutek Tomasz Gorycki Wojciech Zegarski Michał Studniarek |
| author_facet | Bogdan Małkowski Tomasz Staniuk Ewa Śrutek Tomasz Gorycki Wojciech Zegarski Michał Studniarek |
| author_sort | Bogdan Małkowski |
| collection | DOAJ |
| description | The aim of the study was to evaluate the usefulness of 18F-FLT PET/CT in the detection and differentiation of gastric cancers (GC). 104 consecutive patients (57 cases of adenocarcinoma tubulare (G2 and G3), 17 cases of mucinous adenocarcinoma, 6 cases of undifferentiated carcinoma, 14 cases of adenocarcinoma partim mucocellulare, and 10 cases of end stage gastric cancer) with newly diagnosed advanced gastric cancer were examined with FLT PET/CT. For quantitative and comparative analyses, the maximal standardized uptake value (SUVmax) was calculated for both the tumors and noninvaded gastric wall. Results. There were found, in the group of adenocarcinoma tubulare, SUVmax 1.5–23.1 (7.46±4.57), in mucinous adenocarcinoma, SUVmax 2.3–10.3 (5.5±2.4), in undifferentiated carcinoma, SUVmax 3.1–13.6 (7.28±3.25), in adenocarcinoma partim mucocellulare, SUVmax 2–25.3 (7.7±6.99), and, in normal gastric wall, SUVmax 1.01–2.55 (1.84±0.35). For the level of 2.6 cut-off value between the normal wall and neoplasm FLT uptake from ROC analysis, all but five gastric cancers showed higher accumulation of FLT than noninfiltrated mucosa. Conclusion. Gastric cancer presents higher accumulation of 18F-FLT than normal, distended gastric mucosa. Significantly higher accumulation was shown in cancers better differentiated and with higher cellular density. |
| format | Article |
| id | doaj-art-92cc3f999757415e99ec327048ccf589 |
| institution | Kabale University |
| issn | 1687-6121 1687-630X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Gastroenterology Research and Practice |
| spelling | doaj-art-92cc3f999757415e99ec327048ccf5892025-02-03T06:14:11ZengWileyGastroenterology Research and Practice1687-61211687-630X2013-01-01201310.1155/2013/696423696423F18-FLT PET/CT in Patients with Gastric CarcinomaBogdan Małkowski0Tomasz Staniuk1Ewa Śrutek2Tomasz Gorycki3Wojciech Zegarski4Michał Studniarek5Department of Nuclear Medicine, Oncological Centre, Bydgoszcz, PolandDepartment of Oncological Surgery, Oncological Centre, 85-796 Bydgoszcz, PolandDepartment of Cancer Pathology and Pathomorphology, Collegium Medicum, Nicolaus Copernicus University, 85-796 Bydgoszcz, PolandDepartment of Radiology, Medical University of Gdańsk, 80-952 Gdańsk, PolandDepartment of Oncological Surgery, Oncological Centre, 85-796 Bydgoszcz, PolandDepartment of Radiology, Medical University of Gdańsk, 80-952 Gdańsk, PolandThe aim of the study was to evaluate the usefulness of 18F-FLT PET/CT in the detection and differentiation of gastric cancers (GC). 104 consecutive patients (57 cases of adenocarcinoma tubulare (G2 and G3), 17 cases of mucinous adenocarcinoma, 6 cases of undifferentiated carcinoma, 14 cases of adenocarcinoma partim mucocellulare, and 10 cases of end stage gastric cancer) with newly diagnosed advanced gastric cancer were examined with FLT PET/CT. For quantitative and comparative analyses, the maximal standardized uptake value (SUVmax) was calculated for both the tumors and noninvaded gastric wall. Results. There were found, in the group of adenocarcinoma tubulare, SUVmax 1.5–23.1 (7.46±4.57), in mucinous adenocarcinoma, SUVmax 2.3–10.3 (5.5±2.4), in undifferentiated carcinoma, SUVmax 3.1–13.6 (7.28±3.25), in adenocarcinoma partim mucocellulare, SUVmax 2–25.3 (7.7±6.99), and, in normal gastric wall, SUVmax 1.01–2.55 (1.84±0.35). For the level of 2.6 cut-off value between the normal wall and neoplasm FLT uptake from ROC analysis, all but five gastric cancers showed higher accumulation of FLT than noninfiltrated mucosa. Conclusion. Gastric cancer presents higher accumulation of 18F-FLT than normal, distended gastric mucosa. Significantly higher accumulation was shown in cancers better differentiated and with higher cellular density.http://dx.doi.org/10.1155/2013/696423 |
| spellingShingle | Bogdan Małkowski Tomasz Staniuk Ewa Śrutek Tomasz Gorycki Wojciech Zegarski Michał Studniarek F18-FLT PET/CT in Patients with Gastric Carcinoma Gastroenterology Research and Practice |
| title | F18-FLT PET/CT in Patients with Gastric Carcinoma |
| title_full | F18-FLT PET/CT in Patients with Gastric Carcinoma |
| title_fullStr | F18-FLT PET/CT in Patients with Gastric Carcinoma |
| title_full_unstemmed | F18-FLT PET/CT in Patients with Gastric Carcinoma |
| title_short | F18-FLT PET/CT in Patients with Gastric Carcinoma |
| title_sort | f18 flt pet ct in patients with gastric carcinoma |
| url | http://dx.doi.org/10.1155/2013/696423 |
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