Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children
Background. Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods. Eighty-on...
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| Format: | Article |
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Wiley
2012-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2012/235680 |
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| author | Won Kyoung Cho Min Ho Jung So Hyun Park In Cheol Baek Hee-Baeg Choi Tai-Gyu Kim Byung-Kyu Suh |
| author_facet | Won Kyoung Cho Min Ho Jung So Hyun Park In Cheol Baek Hee-Baeg Choi Tai-Gyu Kim Byung-Kyu Suh |
| author_sort | Won Kyoung Cho |
| collection | DOAJ |
| description | Background. Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods. Eighty-one patients with AITD were recruited. We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 70 healthy controls. Results. In AITD, the allele frequencies of MICA*010 (OR=2.21; 95% CI, 1.30–3.76, P<0.003, Pc<0.042) were higher than those of controls. Patients who did not have thyroid-associated ophthalmopathy showed higher frequencies of MICA*010 (OR=2.99; 95% CI, 1.47–6.08, P<0.003, Pc<0.042) and lower frequencies of MICA*008 (OR=0.08; 95% CI, 0.01–0.62, P<0.001, Pc<0.014) compared to those of controls. HLA-B*46, which shows the strongest association with AITD compared with other HLA alleles, showed the strongest linkage disequilibrium with MICA*010. Analyses of the associations between MICA*010 and HLA-B*46 with AITD suggest an association of the MICA allele with AITD. Conclusions. Our results suggest that innate immunity might contribute to the pathogenesis of AITD. |
| format | Article |
| id | doaj-art-92c6d103ea58451387693f0961b09bab |
| institution | DOAJ |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-92c6d103ea58451387693f0961b09bab2025-08-20T03:20:37ZengWileyInternational Journal of Endocrinology1687-83371687-83452012-01-01201210.1155/2012/235680235680Association of MICA Alleles with Autoimmune Thyroid Disease in Korean ChildrenWon Kyoung Cho0Min Ho Jung1So Hyun Park2In Cheol Baek3Hee-Baeg Choi4Tai-Gyu Kim5Byung-Kyu Suh6Department of Pediatrics, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaDepartment of Pediatrics, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaDepartment of Pediatrics, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaDepartment of Microbiology, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaCatholic Hematopoietic Stem Cell Bank, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaDepartment of Microbiology, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaDepartment of Pediatrics, College of Medicine and Seoul St. Mary’s Hospital, The Catholic University of Korea, 505 Banpo-Dong, Seocho-Gu, Seoul 137-040, Republic of KoreaBackground. Major histocompatibility complex class I chain-related gene A (MICA) is a ligand for the activating NKG2D receptor expressed on natural killer (NK) cells. We aimed to assess the association of MICA polymorphism with autoimmune thyroid disease (AITD) in Korean children. Methods. Eighty-one patients with AITD were recruited. We analyzed MICA polymorphisms by PCR-SSP and compared the results with those of 70 healthy controls. Results. In AITD, the allele frequencies of MICA*010 (OR=2.21; 95% CI, 1.30–3.76, P<0.003, Pc<0.042) were higher than those of controls. Patients who did not have thyroid-associated ophthalmopathy showed higher frequencies of MICA*010 (OR=2.99; 95% CI, 1.47–6.08, P<0.003, Pc<0.042) and lower frequencies of MICA*008 (OR=0.08; 95% CI, 0.01–0.62, P<0.001, Pc<0.014) compared to those of controls. HLA-B*46, which shows the strongest association with AITD compared with other HLA alleles, showed the strongest linkage disequilibrium with MICA*010. Analyses of the associations between MICA*010 and HLA-B*46 with AITD suggest an association of the MICA allele with AITD. Conclusions. Our results suggest that innate immunity might contribute to the pathogenesis of AITD.http://dx.doi.org/10.1155/2012/235680 |
| spellingShingle | Won Kyoung Cho Min Ho Jung So Hyun Park In Cheol Baek Hee-Baeg Choi Tai-Gyu Kim Byung-Kyu Suh Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children International Journal of Endocrinology |
| title | Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children |
| title_full | Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children |
| title_fullStr | Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children |
| title_full_unstemmed | Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children |
| title_short | Association of MICA Alleles with Autoimmune Thyroid Disease in Korean Children |
| title_sort | association of mica alleles with autoimmune thyroid disease in korean children |
| url | http://dx.doi.org/10.1155/2012/235680 |
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