Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device
Acute lower respiratory tract infections are a leading cause of death in individuals under the age of 5 years, mostly in low- and middle-income countries (LMICs). The lack of respiratory support systems contributes to the poor outcomes. Bubble CPAP is widely used for non-invasive respiratory support...
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MDPI AG
2025-06-01
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| Series: | Bioengineering |
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| Online Access: | https://www.mdpi.com/2306-5354/12/7/697 |
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| author | Ibukun Sonaike Robert M. DiBlasi Jonathan Arthur Poli Andrew Vamos Ofer Yanay Amelie von Saint Andre-von Arnim |
| author_facet | Ibukun Sonaike Robert M. DiBlasi Jonathan Arthur Poli Andrew Vamos Ofer Yanay Amelie von Saint Andre-von Arnim |
| author_sort | Ibukun Sonaike |
| collection | DOAJ |
| description | Acute lower respiratory tract infections are a leading cause of death in individuals under the age of 5 years, mostly in low- and middle-income countries (LMICs). The lack of respiratory support systems contributes to the poor outcomes. Bubble CPAP is widely used for non-invasive respiratory support, but sicker children often require support over what CPAP provides in the form of BiPAP. We developed and tested a simple bubble-based bilevel ventilator (Bubble bi-vent) and compared it with a standard care BiPAP device. The bubble bilevel device consisted of a single tube submerged in a water-sealed column to maintain end-expiratory positive airway pressure. It moves vertically via an electric motor to also provide inspiratory positive airway pressure for augmentation of lung volumes, with the duration and frequency of breaths controlled by a microprocessor. We tested this novel device in passively breathing mechanical lung models for infants and small children. We compared pressure and tidal volume delivery between the novel device and a Trilogy BiPAP ventilator. The results showed that the Bubble bi-vent could deliver set pressures in a mechanical lung and was comparable to a standard Trilogy ventilator. While two different bubble-based bilevel pressure devices have been piloted for neonates and adults, our results demonstrate the feasibility of bubble bilevel ventilation for infants and small children with moderate to severe lung disease for whom this was previously not described. |
| format | Article |
| id | doaj-art-92c4c8287e4847fdad104cea3bee07c1 |
| institution | Kabale University |
| issn | 2306-5354 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | MDPI AG |
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| series | Bioengineering |
| spelling | doaj-art-92c4c8287e4847fdad104cea3bee07c12025-08-20T03:58:26ZengMDPI AGBioengineering2306-53542025-06-0112769710.3390/bioengineering12070697Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation DeviceIbukun Sonaike0Robert M. DiBlasi1Jonathan Arthur Poli2Andrew Vamos3Ofer Yanay4Amelie von Saint Andre-von Arnim5Department of Pediatrics, Hennepin Healthcare, Minneapolis, MN 55415, USACenter for Respiratory Biology and Therapeutics, Seattle Children’s Research Institute, Seattle, WA 98101, USACenter for Integrative Brain Research, Seattle Children’s Research Institute, Seattle, WA 98101, USAContinuous Improvement and Innovation, Seattle Children’s Research Institute, Seattle, WA 98101, USADepartment of Pediatrics, Division of Pediatric Critical Care Medicine, University of Washington, Seattle Children’s Hospital, Seattle, WA 98105, USADepartment of Pediatrics, Division of Pediatric Critical Care Medicine, University of Washington, Seattle Children’s Hospital, Seattle, WA 98105, USAAcute lower respiratory tract infections are a leading cause of death in individuals under the age of 5 years, mostly in low- and middle-income countries (LMICs). The lack of respiratory support systems contributes to the poor outcomes. Bubble CPAP is widely used for non-invasive respiratory support, but sicker children often require support over what CPAP provides in the form of BiPAP. We developed and tested a simple bubble-based bilevel ventilator (Bubble bi-vent) and compared it with a standard care BiPAP device. The bubble bilevel device consisted of a single tube submerged in a water-sealed column to maintain end-expiratory positive airway pressure. It moves vertically via an electric motor to also provide inspiratory positive airway pressure for augmentation of lung volumes, with the duration and frequency of breaths controlled by a microprocessor. We tested this novel device in passively breathing mechanical lung models for infants and small children. We compared pressure and tidal volume delivery between the novel device and a Trilogy BiPAP ventilator. The results showed that the Bubble bi-vent could deliver set pressures in a mechanical lung and was comparable to a standard Trilogy ventilator. While two different bubble-based bilevel pressure devices have been piloted for neonates and adults, our results demonstrate the feasibility of bubble bilevel ventilation for infants and small children with moderate to severe lung disease for whom this was previously not described.https://www.mdpi.com/2306-5354/12/7/697BiPAPbubble CPAPrespiratory supportventilatorpediatricslow- and middle-income countries |
| spellingShingle | Ibukun Sonaike Robert M. DiBlasi Jonathan Arthur Poli Andrew Vamos Ofer Yanay Amelie von Saint Andre-von Arnim Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device Bioengineering BiPAP bubble CPAP respiratory support ventilator pediatrics low- and middle-income countries |
| title | Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device |
| title_full | Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device |
| title_fullStr | Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device |
| title_full_unstemmed | Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device |
| title_short | Design and Bench Testing of a Novel, Pediatric, Non-Invasive, Bubble Bilevel Positive Pressure Ventilation Device |
| title_sort | design and bench testing of a novel pediatric non invasive bubble bilevel positive pressure ventilation device |
| topic | BiPAP bubble CPAP respiratory support ventilator pediatrics low- and middle-income countries |
| url | https://www.mdpi.com/2306-5354/12/7/697 |
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