Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance
Introduction: The most recent study to report Helicobacter pylori antibiotic resistance rates in Bangladesh was published 15 years ago and did not include levofloxacin. We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin, clarithromycin, metronidazole, t...
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The Journal of Infection in Developing Countries
2016-03-01
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| Series: | Journal of Infection in Developing Countries |
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| Online Access: | https://jidc.org/index.php/journal/article/view/7713 |
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| author | Hafeza Aftab Muhammad Miftahussurur Phawinee Subsomwong Faruque Ahmed AK Azad Khan Yoshio Yamaoka |
| author_facet | Hafeza Aftab Muhammad Miftahussurur Phawinee Subsomwong Faruque Ahmed AK Azad Khan Yoshio Yamaoka |
| author_sort | Hafeza Aftab |
| collection | DOAJ |
| description | Introduction: The most recent study to report Helicobacter pylori antibiotic resistance rates in Bangladesh was published 15 years ago and did not include levofloxacin. We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline and levofloxacin in Bangladesh.
Methodology: This study included 133 consecutive patients who underwent endoscopy examination at Dhaka Medical College in November 2014. The serial two-fold agar dilution method was used to determine the minimum inhibitory concentrations of the five antibiotics.
Results: Among 56 cultured strains, H. pylori showed high rates of resistance to clarithromycin and metronidazole (39.3% and 94.6%, respectively). Moreover, levofloxacin showed an emerging antimicrobial resistance pattern (66.1%), which was higher in patients with gastritis than that in those with peptic ulcers (p = 0.02). The resistance rate of levofloxacin was significantly higher in patients living in Dhaka city compared to those living in the village (p = 0.049). However, amoxicillin and tetracycline resistance rates were very low. Resistance to both metronidazole and levofloxacin was most commonly observed.
Conclusions: The rates of resistance to clarithromycin, metronidazole, and levofloxacin were high in Bangladesh, which suggests that triple therapy based on these drugs may not be useful as first-line therapies in Bangladesh. Alternative strategies such as furazolidone-based triple therapy, bismuth-based quadruple therapies, or sequential therapy may be more effective for patients in in Bangladesh.
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| format | Article |
| id | doaj-art-92c4bbe3c9934ed499d67ea821e9c46e |
| institution | OA Journals |
| issn | 1972-2680 |
| language | English |
| publishDate | 2016-03-01 |
| publisher | The Journal of Infection in Developing Countries |
| record_format | Article |
| series | Journal of Infection in Developing Countries |
| spelling | doaj-art-92c4bbe3c9934ed499d67ea821e9c46e2025-08-20T02:14:20ZengThe Journal of Infection in Developing CountriesJournal of Infection in Developing Countries1972-26802016-03-01100310.3855/jidc.7713Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistanceHafeza Aftab0Muhammad Miftahussurur1Phawinee Subsomwong2Faruque Ahmed3AK Azad Khan4Yoshio Yamaoka5Oita University Faculty of Medicine, Yufu, JapanOita University Faculty of Medicine, Yufu, JapanOita University Faculty of Medicine, Yufu, JapanDhaka Medical College and Hospital, Dhaka, BangladeshBIRDEM, Dhaka, BangladeshOita University Faculty of Medicine, Yufu, JapanIntroduction: The most recent study to report Helicobacter pylori antibiotic resistance rates in Bangladesh was published 15 years ago and did not include levofloxacin. We therefore aimed to determine the current antibiotic susceptibility of H. pylori to amoxicillin, clarithromycin, metronidazole, tetracycline and levofloxacin in Bangladesh. Methodology: This study included 133 consecutive patients who underwent endoscopy examination at Dhaka Medical College in November 2014. The serial two-fold agar dilution method was used to determine the minimum inhibitory concentrations of the five antibiotics. Results: Among 56 cultured strains, H. pylori showed high rates of resistance to clarithromycin and metronidazole (39.3% and 94.6%, respectively). Moreover, levofloxacin showed an emerging antimicrobial resistance pattern (66.1%), which was higher in patients with gastritis than that in those with peptic ulcers (p = 0.02). The resistance rate of levofloxacin was significantly higher in patients living in Dhaka city compared to those living in the village (p = 0.049). However, amoxicillin and tetracycline resistance rates were very low. Resistance to both metronidazole and levofloxacin was most commonly observed. Conclusions: The rates of resistance to clarithromycin, metronidazole, and levofloxacin were high in Bangladesh, which suggests that triple therapy based on these drugs may not be useful as first-line therapies in Bangladesh. Alternative strategies such as furazolidone-based triple therapy, bismuth-based quadruple therapies, or sequential therapy may be more effective for patients in in Bangladesh. https://jidc.org/index.php/journal/article/view/7713Bangladeshdrug resistanceHelicobacter pylori |
| spellingShingle | Hafeza Aftab Muhammad Miftahussurur Phawinee Subsomwong Faruque Ahmed AK Azad Khan Yoshio Yamaoka Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance Journal of Infection in Developing Countries Bangladesh drug resistance Helicobacter pylori |
| title | Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance |
| title_full | Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance |
| title_fullStr | Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance |
| title_full_unstemmed | Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance |
| title_short | Helicobacter pylori antibiotic susceptibility patterns in Bangladesh: Emerging levofloxacin resistance |
| title_sort | helicobacter pylori antibiotic susceptibility patterns in bangladesh emerging levofloxacin resistance |
| topic | Bangladesh drug resistance Helicobacter pylori |
| url | https://jidc.org/index.php/journal/article/view/7713 |
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