LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence

LAMA4+ CD90+ eCAFs provide immunosuppressive microenvironment for liver cancer through induction of CD8+ T cell senescence

Abstract Despite significant advances in cancer biology research and treatment, clinical outcomes for patients with liver cancer remain unsatisfactory. The biological and molecular mechanisms underlying the bidirectional signaling between tumor cells and the tumor microenvironment (TME), which promo...

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Main Authors: Jianlei Zhang, Zhihui Li, Qiong Zhang, Wen Ma, Weina Fan, Jing Dong, Jingjie Tian, Hongfan Liao, Junzhe Guo, Yabing Cao, Jiang Yin, Guopei Zheng, Nan Li
Format: Article
Language:English
Published: BMC 2025-04-01
Series:Cell Communication and Signaling
Subjects:
Liver cancer
Cancer-associated fibroblasts
LAMA4
T cell senescence
Online Access:https://doi.org/10.1186/s12964-025-02162-7
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