Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study
ABSTRACT Background and Aims Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. that could preciptate variable acute or end‐organ manifestation. However, the degree of inflammati...
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Wiley
2025-05-01
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| Series: | Health Science Reports |
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| Online Access: | https://doi.org/10.1002/hsr2.70773 |
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| author | Romaric De Manfouo Tuono Josué Louokdom Simo Prosper Cabral Biapa Nya Claude Tagny Tayou Constant Anatole Pieme |
| author_facet | Romaric De Manfouo Tuono Josué Louokdom Simo Prosper Cabral Biapa Nya Claude Tagny Tayou Constant Anatole Pieme |
| author_sort | Romaric De Manfouo Tuono |
| collection | DOAJ |
| description | ABSTRACT Background and Aims Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. that could preciptate variable acute or end‐organ manifestation. However, the degree of inflammation could vary in individuals. Thus this study evaluates the inflammatory state (hs‐CRP, IL6, ferritin) of children living with SCD and the associated factors. Methods We conducted an analytical cross‐sectional study for 03 months. The patients included were those from the Central Hospital of Yaounde and the Regional Hospital of Bafoussam in which they are regularly monitored and/or interned in the Hematology department. The exploration of inflammation was made by determining hs‐CRP, IL6, and ferritin concentrations. The hematological parameters and iron profile were evaluated using standard methods. Statistical analyses of the data were carried out using the statistical software R version 4.1.1. from which logistic regression analyses according to univariate and multivariate models made it possible to identify factors associated with inflammation in patients. Results Hundred and forty‐nine SCD patients were included in the study. The frequency of inflammation in the population was 42.3%. Hyperferritinemia was significantly greater (p < 0.001) in patients with inflammation compared to the noninflammatory patients (96.8% and 76.7% respectively). Patients with inflammation showed a significant elevation of iron parameters (p < 0.05). In addition, ferritin and IL6 elevation were associated with inflammation during sickle cell disease, respectively (OR = 4.96; 95% CI [1.15–36.42]; p = 0.056) and (OR = 6.23; 95% CI [1.43–45.96]; p = 0.030). Conclusion The elevated iron in plasma is an effect of inflammation in sickle cell patients. Thus, inflammation constitutes a significant and significant factor in worsening the pathophysiology of sickle cell disease. Hence the need of controlling inflammation and iron in the latter is necessary. |
| format | Article |
| id | doaj-art-92aab73442144fdc8b9bf4aaeb29566b |
| institution | Kabale University |
| issn | 2398-8835 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Health Science Reports |
| spelling | doaj-art-92aab73442144fdc8b9bf4aaeb29566b2025-08-20T03:39:21ZengWileyHealth Science Reports2398-88352025-05-0185n/an/a10.1002/hsr2.70773Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional StudyRomaric De Manfouo Tuono0Josué Louokdom Simo1Prosper Cabral Biapa Nya2Claude Tagny Tayou3Constant Anatole Pieme4Faculty of Medicine and Biomedical Sciences Université de Yaoundé 1 Yaoundé CameroonHigher Institute of Health Science Université des Montagnes Bangangté CameroonFaculty of Sciences Université of Dschang Dschang CameroonDepartment of Microbiology, Parasitology, Haematology, and Infectious Disease Faculty of Medicine and Biomedical Sciences Université de Yaoundé 1 Yaoundé CameroonBiochemistry Laboratory, Department of Biochemistry, Faculty of Medicine and Biomedical Sciences Université de Yaoundé 1 Yaoundé CameroonABSTRACT Background and Aims Sickle Cell Disease is a chronic inflammatory disease that could be aggravated by exposure to variable factors such as infections, hemolysis, oxidative stress and so forth. that could preciptate variable acute or end‐organ manifestation. However, the degree of inflammation could vary in individuals. Thus this study evaluates the inflammatory state (hs‐CRP, IL6, ferritin) of children living with SCD and the associated factors. Methods We conducted an analytical cross‐sectional study for 03 months. The patients included were those from the Central Hospital of Yaounde and the Regional Hospital of Bafoussam in which they are regularly monitored and/or interned in the Hematology department. The exploration of inflammation was made by determining hs‐CRP, IL6, and ferritin concentrations. The hematological parameters and iron profile were evaluated using standard methods. Statistical analyses of the data were carried out using the statistical software R version 4.1.1. from which logistic regression analyses according to univariate and multivariate models made it possible to identify factors associated with inflammation in patients. Results Hundred and forty‐nine SCD patients were included in the study. The frequency of inflammation in the population was 42.3%. Hyperferritinemia was significantly greater (p < 0.001) in patients with inflammation compared to the noninflammatory patients (96.8% and 76.7% respectively). Patients with inflammation showed a significant elevation of iron parameters (p < 0.05). In addition, ferritin and IL6 elevation were associated with inflammation during sickle cell disease, respectively (OR = 4.96; 95% CI [1.15–36.42]; p = 0.056) and (OR = 6.23; 95% CI [1.43–45.96]; p = 0.030). Conclusion The elevated iron in plasma is an effect of inflammation in sickle cell patients. Thus, inflammation constitutes a significant and significant factor in worsening the pathophysiology of sickle cell disease. Hence the need of controlling inflammation and iron in the latter is necessary.https://doi.org/10.1002/hsr2.70773associated factorsinflammationiron profilesickle cell anemia |
| spellingShingle | Romaric De Manfouo Tuono Josué Louokdom Simo Prosper Cabral Biapa Nya Claude Tagny Tayou Constant Anatole Pieme Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study Health Science Reports associated factors inflammation iron profile sickle cell anemia |
| title | Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study |
| title_full | Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study |
| title_fullStr | Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study |
| title_full_unstemmed | Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study |
| title_short | Inflammation and Iron Profile in Children With Sickle Cell Disease in Cameroon: Frequency and Associated Factors, an Analytical Cross‐Sectional Study |
| title_sort | inflammation and iron profile in children with sickle cell disease in cameroon frequency and associated factors an analytical cross sectional study |
| topic | associated factors inflammation iron profile sickle cell anemia |
| url | https://doi.org/10.1002/hsr2.70773 |
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