Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review
Introduction The opioid crisis has resulted in increasing rates of death caused by problematic opioid use. Current clinical guidelines recommend that individuals with persons with opioid use disorder (OUD) receive pharmacological (eg, opioid agonist therapy) and psychosocial (eg, cognitive behaviour...
Saved in:
| Main Authors: | , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMJ Publishing Group
2018-10-01
|
| Series: | BMJ Open |
| Online Access: | https://bmjopen.bmj.com/content/8/10/e023902.full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832574309590106112 |
|---|---|
| author | Brian Hutton Beverley Shea Kimberly Corace David Moher Danielle B Rice Becky Skidmore Kednapa Thavorn Sheena Taha Dianna Wolfe Fatemeh Yazdi Beth A Sproule Melanie Willows Patricia Poulin Gary Garber Amy Porath Leila Esmaeilisaraji |
| author_facet | Brian Hutton Beverley Shea Kimberly Corace David Moher Danielle B Rice Becky Skidmore Kednapa Thavorn Sheena Taha Dianna Wolfe Fatemeh Yazdi Beth A Sproule Melanie Willows Patricia Poulin Gary Garber Amy Porath Leila Esmaeilisaraji |
| author_sort | Brian Hutton |
| collection | DOAJ |
| description | Introduction The opioid crisis has resulted in increasing rates of death caused by problematic opioid use. Current clinical guidelines recommend that individuals with persons with opioid use disorder (OUD) receive pharmacological (eg, opioid agonist therapy) and psychosocial (eg, cognitive behavioural therapy) therapy; however, the best combination of pharmacologic and psychosocial components is not known. Our objective of the planned study is to conduct a comprehensive systematic review to assess the relative benefits of psychosocial interventions as an adjunct to opioid agonist therapy among persons with OUD.Methods and analysis A comprehensive search for randomised controlled trials published in English or French will be conducted from database inception to March 2018. The search will be conducted in MEDLINE and translated for Embase, PsycINFO and the Cochrane Central Register of Controlled Trials. Two independent reviewers will screen, extract and assess risk of bias of eligible articles. Primary outcomes of interest will be treatment retention and opioid use (based on urinalysis results). Secondary outcomes will include self-reported opioid use, abstinence from illicit drugs, adherence to psychosocial therapy and opioid agonist therapy, risk for sexually transmitted disease, risk for blood borne pathogens, changes in mental health symptoms (eg, depression), measures of craving and changes in patients’ quality of life and relevant adverse events. If sufficient data and adequate homogeneity exists, network meta-analyses (NMA) will be performed.Ethics and dissemination This will be the first systematic review to incorporate NMA to compare psychosocial treatments used as an adjunct to opioid agonist therapy for OUD. Results of this review will inform clinical management of persons with OUD.Trial registration number CRD42018090761. |
| format | Article |
| id | doaj-art-92a3e4cd095a4f6285aac2643f1c1268 |
| institution | Kabale University |
| issn | 2044-6055 |
| language | English |
| publishDate | 2018-10-01 |
| publisher | BMJ Publishing Group |
| record_format | Article |
| series | BMJ Open |
| spelling | doaj-art-92a3e4cd095a4f6285aac2643f1c12682025-02-01T23:55:09ZengBMJ Publishing GroupBMJ Open2044-60552018-10-0181010.1136/bmjopen-2018-023902Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic reviewBrian Hutton0Beverley Shea1Kimberly Corace2David Moher3Danielle B Rice4Becky Skidmore5Kednapa Thavorn6Sheena Taha7Dianna Wolfe8Fatemeh Yazdi9Beth A Sproule10Melanie Willows11Patricia Poulin12Gary Garber13Amy Porath14Leila Esmaeilisaraji15Clinical Epidemiology Program, the Ottawa Hospital Research Institute, Ottawa, ON, Canada13 University of Ottawa, Ottawa, Ontario, Canada10 Institute of Mental Health Research, University of Ottawa, Ottawa, Ontario, Canada8 Centre for Journalology, Clinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada1 Clinical Epidemiology, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada6 Independent Information Specialist Consultant, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, Canada5 Canadian Centre on Substance Use and Addiction, Ottawa, Ontario, Canadasenior research associatesenior clinical research associate6 Department of Pharmacy, Centre for Addiction and Mental Health, Toronto, Ontario, CanadaInstitute of Mental Health Research, University of Ottawa, Ottawa, Ontario, CanadaSchool of Epidemiology and Public Health, University of Ottawa, Ottawa, Ontario, CanadaSafe Medical Care Research, Canadian Medical Protective Association, Ottawa, Ontario, Canada10 Canadian Center on Substance Use and Addiction, Ottawa, Ontario, CanadaClinical Epidemiology Program, Ottawa Hospital Research Institute, Ottawa, Ontario, CanadaIntroduction The opioid crisis has resulted in increasing rates of death caused by problematic opioid use. Current clinical guidelines recommend that individuals with persons with opioid use disorder (OUD) receive pharmacological (eg, opioid agonist therapy) and psychosocial (eg, cognitive behavioural therapy) therapy; however, the best combination of pharmacologic and psychosocial components is not known. Our objective of the planned study is to conduct a comprehensive systematic review to assess the relative benefits of psychosocial interventions as an adjunct to opioid agonist therapy among persons with OUD.Methods and analysis A comprehensive search for randomised controlled trials published in English or French will be conducted from database inception to March 2018. The search will be conducted in MEDLINE and translated for Embase, PsycINFO and the Cochrane Central Register of Controlled Trials. Two independent reviewers will screen, extract and assess risk of bias of eligible articles. Primary outcomes of interest will be treatment retention and opioid use (based on urinalysis results). Secondary outcomes will include self-reported opioid use, abstinence from illicit drugs, adherence to psychosocial therapy and opioid agonist therapy, risk for sexually transmitted disease, risk for blood borne pathogens, changes in mental health symptoms (eg, depression), measures of craving and changes in patients’ quality of life and relevant adverse events. If sufficient data and adequate homogeneity exists, network meta-analyses (NMA) will be performed.Ethics and dissemination This will be the first systematic review to incorporate NMA to compare psychosocial treatments used as an adjunct to opioid agonist therapy for OUD. Results of this review will inform clinical management of persons with OUD.Trial registration number CRD42018090761.https://bmjopen.bmj.com/content/8/10/e023902.full |
| spellingShingle | Brian Hutton Beverley Shea Kimberly Corace David Moher Danielle B Rice Becky Skidmore Kednapa Thavorn Sheena Taha Dianna Wolfe Fatemeh Yazdi Beth A Sproule Melanie Willows Patricia Poulin Gary Garber Amy Porath Leila Esmaeilisaraji Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review BMJ Open |
| title | Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review |
| title_full | Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review |
| title_fullStr | Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review |
| title_full_unstemmed | Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review |
| title_short | Evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder: protocol for a systematic review |
| title_sort | evaluating comparative effectiveness of psychosocial interventions for persons receiving opioid agonist therapy for opioid use disorder protocol for a systematic review |
| url | https://bmjopen.bmj.com/content/8/10/e023902.full |
| work_keys_str_mv | AT brianhutton evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT beverleyshea evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT kimberlycorace evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT davidmoher evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT daniellebrice evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT beckyskidmore evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT kednapathavorn evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT sheenataha evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT diannawolfe evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT fatemehyazdi evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT bethasproule evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT melaniewillows evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT patriciapoulin evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT garygarber evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT amyporath evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview AT leilaesmaeilisaraji evaluatingcomparativeeffectivenessofpsychosocialinterventionsforpersonsreceivingopioidagonisttherapyforopioidusedisorderprotocolforasystematicreview |