Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results
Purpose. To present our results after short-term (1 month) intra-arterial infusion therapy of PGE1-alprostadil via a port system implanted in the ipsilateral external iliac artery (EIA) in patients with severe rest pain. Methods. Ten patients with severe rest pain were included. All patients showed...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/2012/803678 |
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| author | A. Chatziioannou A. Dalakidis K. Katsenis V. Koutoulidis D. Mourikis |
| author_facet | A. Chatziioannou A. Dalakidis K. Katsenis V. Koutoulidis D. Mourikis |
| author_sort | A. Chatziioannou |
| collection | DOAJ |
| description | Purpose. To present our results after short-term (1 month) intra-arterial infusion therapy of PGE1-alprostadil via a port system implanted in the ipsilateral external iliac artery (EIA) in patients with severe rest pain. Methods. Ten patients with severe rest pain were included. All patients showed extensive peripheral vascular disease below the knee. The tip of the catheter was introduced via a retrograde puncture in the ipsilateral external iliac artery (EIA). The patients received intraarterial infusion of PGE1, 20 mgr alprostadil daily, via the port catheter for 1 month. Results. Clinical success was evaluated according to subjective grading of pain (group A significant decrease, group B moderate decrease and group C no response). A significant decrease of rest pain was observed in 8 (group A, 80%) patients, a moderate decrease in 2 (Group B, 20%), whereas no patients demonstrated any significant response. Both patients of group B had Buergers' disease and continue to smoke during therapy. No peripheral thrombosis or clinical deterioration was noticed. Conclusion. Intraarterial infusion of PGE1 alprostadil on a daily basis, using a port catheter into the ipsilateral EIA, in selected patients with severe rest pain, seems to be very effective, without any serious complications. |
| format | Article |
| id | doaj-art-929ee95a91e44052ade07afd7e681cc2 |
| institution | Kabale University |
| issn | 1537-744X |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-929ee95a91e44052ade07afd7e681cc22025-02-03T05:44:49ZengWileyThe Scientific World Journal1537-744X2012-01-01201210.1100/2012/803678803678Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term ResultsA. Chatziioannou0A. Dalakidis1K. Katsenis2V. Koutoulidis3D. Mourikis4Department of Interventional Radiology, Aretaieion Hospital, University of Athens, 76 Vas. Sofias Avenue, 115 28 Athens, GreeceDepartment of Interventional Radiology, Aretaieion Hospital, University of Athens, 76 Vas. Sofias Avenue, 115 28 Athens, GreeceDepartment of Vascular Surgery, Aretaieion Hospital, Aretaieion Hospital, 76 Vas. Sofias Avenue, 115 28 Athens, GreeceDepartment of Interventional Radiology, Aretaieion Hospital, University of Athens, 76 Vas. Sofias Avenue, 115 28 Athens, GreeceDepartment of Interventional Radiology, Aretaieion Hospital, University of Athens, 76 Vas. Sofias Avenue, 115 28 Athens, GreecePurpose. To present our results after short-term (1 month) intra-arterial infusion therapy of PGE1-alprostadil via a port system implanted in the ipsilateral external iliac artery (EIA) in patients with severe rest pain. Methods. Ten patients with severe rest pain were included. All patients showed extensive peripheral vascular disease below the knee. The tip of the catheter was introduced via a retrograde puncture in the ipsilateral external iliac artery (EIA). The patients received intraarterial infusion of PGE1, 20 mgr alprostadil daily, via the port catheter for 1 month. Results. Clinical success was evaluated according to subjective grading of pain (group A significant decrease, group B moderate decrease and group C no response). A significant decrease of rest pain was observed in 8 (group A, 80%) patients, a moderate decrease in 2 (Group B, 20%), whereas no patients demonstrated any significant response. Both patients of group B had Buergers' disease and continue to smoke during therapy. No peripheral thrombosis or clinical deterioration was noticed. Conclusion. Intraarterial infusion of PGE1 alprostadil on a daily basis, using a port catheter into the ipsilateral EIA, in selected patients with severe rest pain, seems to be very effective, without any serious complications.http://dx.doi.org/10.1100/2012/803678 |
| spellingShingle | A. Chatziioannou A. Dalakidis K. Katsenis V. Koutoulidis D. Mourikis Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results The Scientific World Journal |
| title | Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results |
| title_full | Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results |
| title_fullStr | Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results |
| title_full_unstemmed | Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results |
| title_short | Intra-Arterial Prostaglandin E1 Infusion in Patients with Rest Pain: Short-Term Results |
| title_sort | intra arterial prostaglandin e1 infusion in patients with rest pain short term results |
| url | http://dx.doi.org/10.1100/2012/803678 |
| work_keys_str_mv | AT achatziioannou intraarterialprostaglandine1infusioninpatientswithrestpainshorttermresults AT adalakidis intraarterialprostaglandine1infusioninpatientswithrestpainshorttermresults AT kkatsenis intraarterialprostaglandine1infusioninpatientswithrestpainshorttermresults AT vkoutoulidis intraarterialprostaglandine1infusioninpatientswithrestpainshorttermresults AT dmourikis intraarterialprostaglandine1infusioninpatientswithrestpainshorttermresults |