Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications
Prostate cancer is one of the most prevalent malignancies globally. This cancerous condition originates within the prostate gland, an integral part of the male reproductive system. The molecular mechanism underlying cancer is among the key areas of research in the scientific community. Cancer, being...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-04-01
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| Series: | Frontiers in Oncology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2025.1570193/full |
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| author | Bunty Sharma Himanshu Shekhar Anidrisha Sahu Damandeep Kaur Shafiul Haque Shafiul Haque Hardeep Singh Tuli Himanshu Sharma Ujjawal Sharma |
| author_facet | Bunty Sharma Himanshu Shekhar Anidrisha Sahu Damandeep Kaur Shafiul Haque Shafiul Haque Hardeep Singh Tuli Himanshu Sharma Ujjawal Sharma |
| author_sort | Bunty Sharma |
| collection | DOAJ |
| description | Prostate cancer is one of the most prevalent malignancies globally. This cancerous condition originates within the prostate gland, an integral part of the male reproductive system. The molecular mechanism underlying cancer is among the key areas of research in the scientific community. Cancer, being a multifactorial disease, is controlled by many factors ranging from environmental to genetic to epigenetic factors. Epigenetic regulation holds a crucial role in tumorigenesis and its progression. Epigenetics refers to alterations in the genome that happen without any changes to the DNA sequence itself; they may be triggered by multiple factors ranging from environmental to dietary factors. It includes methylation of DNA and histone modifications. Histone modifications, including histone methylation, histone acetylation, and histone ubiquitination, play a crucial role in the pathogenesis and progression of prostate cancer. These epigenetic modifications via transcriptional regulation affect key cellular processes and are thus implicated in prostate cancer and other cancers. These epigenetic markers could be used as both diagnostic and prognostic markers and also could be used as novel therapeutic targets against prostate cancer and other malignancies. Here in this review article, we have summarized different histone modifications and their mechanistic and therapeutic implications in prostate cancer. |
| format | Article |
| id | doaj-art-929b9a49a3104169b0e23db52d44f4ee |
| institution | OA Journals |
| issn | 2234-943X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj-art-929b9a49a3104169b0e23db52d44f4ee2025-08-20T02:20:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2025-04-011510.3389/fonc.2025.15701931570193Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implicationsBunty Sharma0Himanshu Shekhar1Anidrisha Sahu2Damandeep Kaur3Shafiul Haque4Shafiul Haque5Hardeep Singh Tuli6Himanshu Sharma7Ujjawal Sharma8Department of Biotechnology, Graphic Era (Deemed to be University), Dehradun, Uttarakhand, IndiaDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda, IndiaDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda, IndiaUniversity Center for Research and Development (UCRD), Chandigarh University, Mohali, Punjab, IndiaCollege of Nursing and Health Sciences, Jazan University, Jazan, Saudi ArabiaSchool of Medicine, Universidad Espiritu Santo, Samborondon, EcuadorDepartment of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana, IndiaDepartment of Biochemistry, All India Institute of Medical Sciences, Bathinda, IndiaDepartment of Human Genetics and Molecular Medicine, Central University of Punjab, Bhatinda, IndiaProstate cancer is one of the most prevalent malignancies globally. This cancerous condition originates within the prostate gland, an integral part of the male reproductive system. The molecular mechanism underlying cancer is among the key areas of research in the scientific community. Cancer, being a multifactorial disease, is controlled by many factors ranging from environmental to genetic to epigenetic factors. Epigenetic regulation holds a crucial role in tumorigenesis and its progression. Epigenetics refers to alterations in the genome that happen without any changes to the DNA sequence itself; they may be triggered by multiple factors ranging from environmental to dietary factors. It includes methylation of DNA and histone modifications. Histone modifications, including histone methylation, histone acetylation, and histone ubiquitination, play a crucial role in the pathogenesis and progression of prostate cancer. These epigenetic modifications via transcriptional regulation affect key cellular processes and are thus implicated in prostate cancer and other cancers. These epigenetic markers could be used as both diagnostic and prognostic markers and also could be used as novel therapeutic targets against prostate cancer and other malignancies. Here in this review article, we have summarized different histone modifications and their mechanistic and therapeutic implications in prostate cancer.https://www.frontiersin.org/articles/10.3389/fonc.2025.1570193/fullprostate cancerepigeneticshistone modificationtherapeuticsepigenetic modifications |
| spellingShingle | Bunty Sharma Himanshu Shekhar Anidrisha Sahu Damandeep Kaur Shafiul Haque Shafiul Haque Hardeep Singh Tuli Himanshu Sharma Ujjawal Sharma Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications Frontiers in Oncology prostate cancer epigenetics histone modification therapeutics epigenetic modifications |
| title | Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications |
| title_full | Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications |
| title_fullStr | Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications |
| title_full_unstemmed | Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications |
| title_short | Epigenetic insights into prostate cancer: exploring histone modifications and their therapeutic implications |
| title_sort | epigenetic insights into prostate cancer exploring histone modifications and their therapeutic implications |
| topic | prostate cancer epigenetics histone modification therapeutics epigenetic modifications |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2025.1570193/full |
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