Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series
ObjectiveThe aim of this report is to raise awareness of the risk of oxidant-induced erythrocyte injury, including Heinz body (HB) anemia, in critically ill dogs by describing the condition in five dogs receiving constant rate infusions of propofol.Case summaryThis case series describes five dogs wi...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2025-02-01
|
| Series: | Frontiers in Veterinary Science |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2025.1500464/full |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1832542835895697408 |
|---|---|
| author | Emily M. Ireland Claire R. Sharp Ellie M. Leister Susan Boyd |
| author_facet | Emily M. Ireland Claire R. Sharp Ellie M. Leister Susan Boyd |
| author_sort | Emily M. Ireland |
| collection | DOAJ |
| description | ObjectiveThe aim of this report is to raise awareness of the risk of oxidant-induced erythrocyte injury, including Heinz body (HB) anemia, in critically ill dogs by describing the condition in five dogs receiving constant rate infusions of propofol.Case summaryThis case series describes five dogs with suspected propofol-induced HB anemia undergoing mechanical ventilation (MV) for lower motor neuron disease. Four of the five dogs were treated for tick paralysis (Ixodes holocyclus) and one was treated for suspected eastern brown snake (Pseudonaja textilis) envenomation. Propofol constant rate infusions were administered as part of total intravenous anesthesia. All five dogs became anemic, and a complete blood count and blood smear interpretation by a specialist clinical pathologist confirmed the presence of oxidative red blood cell injury (eccentrocytosis and HBs). The duration of MV ranged from 76 to 131 h, with HBs identified within 47–96 h of commencing propofol. All five dogs survived to discharge, with one dog requiring a blood transfusion.DiscussionWhile propofol-induced HB anemia is a recognized phenomenon in cats, to the author’s knowledge, this is the first case series detailing multiple occurrences in dogs. Veterinarians should be aware of the risk of propofol-induced oxidative erythrocyte injury in dogs receiving prolonged infusions of propofol, and consider risk mitigation by using propofol as part of multiagent intravenous anesthesia, keeping dose rates as low as possible, and daily monitoring of blood smears and red blood cell indices. |
| format | Article |
| id | doaj-art-92974ead456b496da5572bd44407acfd |
| institution | Kabale University |
| issn | 2297-1769 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj-art-92974ead456b496da5572bd44407acfd2025-02-03T15:27:19ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692025-02-011210.3389/fvets.2025.15004641500464Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case seriesEmily M. Ireland0Claire R. Sharp1Ellie M. Leister2Susan Boyd3Brisbane Veterinary Emergency and Critical Care Service, Albany Creek, QLD, AustraliaSchool of Veterinary Medicine, Murdoch University, Murdoch, WA, AustraliaPet Intensive Care Unit, Underwood, QLD, AustraliaVetnostics Pathology, Murarrie, QLD, AustraliaObjectiveThe aim of this report is to raise awareness of the risk of oxidant-induced erythrocyte injury, including Heinz body (HB) anemia, in critically ill dogs by describing the condition in five dogs receiving constant rate infusions of propofol.Case summaryThis case series describes five dogs with suspected propofol-induced HB anemia undergoing mechanical ventilation (MV) for lower motor neuron disease. Four of the five dogs were treated for tick paralysis (Ixodes holocyclus) and one was treated for suspected eastern brown snake (Pseudonaja textilis) envenomation. Propofol constant rate infusions were administered as part of total intravenous anesthesia. All five dogs became anemic, and a complete blood count and blood smear interpretation by a specialist clinical pathologist confirmed the presence of oxidative red blood cell injury (eccentrocytosis and HBs). The duration of MV ranged from 76 to 131 h, with HBs identified within 47–96 h of commencing propofol. All five dogs survived to discharge, with one dog requiring a blood transfusion.DiscussionWhile propofol-induced HB anemia is a recognized phenomenon in cats, to the author’s knowledge, this is the first case series detailing multiple occurrences in dogs. Veterinarians should be aware of the risk of propofol-induced oxidative erythrocyte injury in dogs receiving prolonged infusions of propofol, and consider risk mitigation by using propofol as part of multiagent intravenous anesthesia, keeping dose rates as low as possible, and daily monitoring of blood smears and red blood cell indices.https://www.frontiersin.org/articles/10.3389/fvets.2025.1500464/fulloxidanterythrocyteeccentrocytosispropofoltick paralysissnake envenomation |
| spellingShingle | Emily M. Ireland Claire R. Sharp Ellie M. Leister Susan Boyd Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series Frontiers in Veterinary Science oxidant erythrocyte eccentrocytosis propofol tick paralysis snake envenomation |
| title | Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series |
| title_full | Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series |
| title_fullStr | Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series |
| title_full_unstemmed | Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series |
| title_short | Case report: Suspected propofol associated Heinz body anemia in five mechanically ventilated dogs: a historical case series |
| title_sort | case report suspected propofol associated heinz body anemia in five mechanically ventilated dogs a historical case series |
| topic | oxidant erythrocyte eccentrocytosis propofol tick paralysis snake envenomation |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2025.1500464/full |
| work_keys_str_mv | AT emilymireland casereportsuspectedpropofolassociatedheinzbodyanemiainfivemechanicallyventilateddogsahistoricalcaseseries AT clairersharp casereportsuspectedpropofolassociatedheinzbodyanemiainfivemechanicallyventilateddogsahistoricalcaseseries AT elliemleister casereportsuspectedpropofolassociatedheinzbodyanemiainfivemechanicallyventilateddogsahistoricalcaseseries AT susanboyd casereportsuspectedpropofolassociatedheinzbodyanemiainfivemechanicallyventilateddogsahistoricalcaseseries |