A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
Four-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and...
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2015-01-01
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Series: | Mediators of Inflammation |
Online Access: | http://dx.doi.org/10.1155/2015/923248 |
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author | Nelson Inacio Pinto Neto Maria Elizabeth Sousa Rodrigues Ana Claudia Losinskas Hachul Mayara Franzoi Moreno Valter Tadeu Boldarine Eliane Beraldi Ribeiro Lila Missae Oyama Claudia Maria Oller do Nascimento |
author_facet | Nelson Inacio Pinto Neto Maria Elizabeth Sousa Rodrigues Ana Claudia Losinskas Hachul Mayara Franzoi Moreno Valter Tadeu Boldarine Eliane Beraldi Ribeiro Lila Missae Oyama Claudia Maria Oller do Nascimento |
author_sort | Nelson Inacio Pinto Neto |
collection | DOAJ |
description | Four-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and carcass lipid content were higher in the OVX H than in the SHAM H. The OVX H exhibited a higher serum leptin level than other groups. IL-6, TNF-α, and IL-10 content of mesenteric (MES) adipose tissue was lower in the OVX H than in the OVX C. IL-6, TNF-α, and IL-10 content of retroperitoneal (RET) adipose tissue was lower in the SHAM H than in the SHAM C. The SHAM H showed decreased TG relative to the SHAM C. Similar results were obtained in relation to IL-6Rα, TNFR1, TLR-4, and MyD88 contents in the MES and RET white adipose tissue among the groups. A hyperlipidic diet for 8 weeks combined with short-term ovariectomy decreases the cytokine content of MES adipose tissues but increases BW, enhancing FE and elevating serum leptin levels. These suggest that the absence of estrogens promotes metabolic changes that may contribute to installation of a proinflammatory process induced by a hyperlipidic diet. |
format | Article |
id | doaj-art-92950fb04028414da94be17dece1ab87 |
institution | Kabale University |
issn | 0962-9351 1466-1861 |
language | English |
publishDate | 2015-01-01 |
publisher | Wiley |
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series | Mediators of Inflammation |
spelling | doaj-art-92950fb04028414da94be17dece1ab872025-02-03T01:31:58ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/923248923248A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose TissueNelson Inacio Pinto Neto0Maria Elizabeth Sousa Rodrigues1Ana Claudia Losinskas Hachul2Mayara Franzoi Moreno3Valter Tadeu Boldarine4Eliane Beraldi Ribeiro5Lila Missae Oyama6Claudia Maria Oller do Nascimento7Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilFour-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and carcass lipid content were higher in the OVX H than in the SHAM H. The OVX H exhibited a higher serum leptin level than other groups. IL-6, TNF-α, and IL-10 content of mesenteric (MES) adipose tissue was lower in the OVX H than in the OVX C. IL-6, TNF-α, and IL-10 content of retroperitoneal (RET) adipose tissue was lower in the SHAM H than in the SHAM C. The SHAM H showed decreased TG relative to the SHAM C. Similar results were obtained in relation to IL-6Rα, TNFR1, TLR-4, and MyD88 contents in the MES and RET white adipose tissue among the groups. A hyperlipidic diet for 8 weeks combined with short-term ovariectomy decreases the cytokine content of MES adipose tissues but increases BW, enhancing FE and elevating serum leptin levels. These suggest that the absence of estrogens promotes metabolic changes that may contribute to installation of a proinflammatory process induced by a hyperlipidic diet.http://dx.doi.org/10.1155/2015/923248 |
spellingShingle | Nelson Inacio Pinto Neto Maria Elizabeth Sousa Rodrigues Ana Claudia Losinskas Hachul Mayara Franzoi Moreno Valter Tadeu Boldarine Eliane Beraldi Ribeiro Lila Missae Oyama Claudia Maria Oller do Nascimento A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue Mediators of Inflammation |
title | A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue |
title_full | A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue |
title_fullStr | A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue |
title_full_unstemmed | A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue |
title_short | A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue |
title_sort | hyperlipidic diet combined with short term ovariectomy increases adiposity and hyperleptinemia and decreases cytokine content in mesenteric adipose tissue |
url | http://dx.doi.org/10.1155/2015/923248 |
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