A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue

Four-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and...

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Main Authors: Nelson Inacio Pinto Neto, Maria Elizabeth Sousa Rodrigues, Ana Claudia Losinskas Hachul, Mayara Franzoi Moreno, Valter Tadeu Boldarine, Eliane Beraldi Ribeiro, Lila Missae Oyama, Claudia Maria Oller do Nascimento
Format: Article
Language:English
Published: Wiley 2015-01-01
Series:Mediators of Inflammation
Online Access:http://dx.doi.org/10.1155/2015/923248
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author Nelson Inacio Pinto Neto
Maria Elizabeth Sousa Rodrigues
Ana Claudia Losinskas Hachul
Mayara Franzoi Moreno
Valter Tadeu Boldarine
Eliane Beraldi Ribeiro
Lila Missae Oyama
Claudia Maria Oller do Nascimento
author_facet Nelson Inacio Pinto Neto
Maria Elizabeth Sousa Rodrigues
Ana Claudia Losinskas Hachul
Mayara Franzoi Moreno
Valter Tadeu Boldarine
Eliane Beraldi Ribeiro
Lila Missae Oyama
Claudia Maria Oller do Nascimento
author_sort Nelson Inacio Pinto Neto
collection DOAJ
description Four-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and carcass lipid content were higher in the OVX H than in the SHAM H. The OVX H exhibited a higher serum leptin level than other groups. IL-6, TNF-α, and IL-10 content of mesenteric (MES) adipose tissue was lower in the OVX H than in the OVX C. IL-6, TNF-α, and IL-10 content of retroperitoneal (RET) adipose tissue was lower in the SHAM H than in the SHAM C. The SHAM H showed decreased TG relative to the SHAM C. Similar results were obtained in relation to IL-6Rα, TNFR1, TLR-4, and MyD88 contents in the MES and RET white adipose tissue among the groups. A hyperlipidic diet for 8 weeks combined with short-term ovariectomy decreases the cytokine content of MES adipose tissues but increases BW, enhancing FE and elevating serum leptin levels. These suggest that the absence of estrogens promotes metabolic changes that may contribute to installation of a proinflammatory process induced by a hyperlipidic diet.
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spelling doaj-art-92950fb04028414da94be17dece1ab872025-02-03T01:31:58ZengWileyMediators of Inflammation0962-93511466-18612015-01-01201510.1155/2015/923248923248A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose TissueNelson Inacio Pinto Neto0Maria Elizabeth Sousa Rodrigues1Ana Claudia Losinskas Hachul2Mayara Franzoi Moreno3Valter Tadeu Boldarine4Eliane Beraldi Ribeiro5Lila Missae Oyama6Claudia Maria Oller do Nascimento7Departamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilDepartamento de Fisiologia, Disciplina de Fisiologia da Nutrição, Universidade Federal de São Paulo, Rua Botucatu 862, 2nd floor, Edifício de Ciências Biomédicas, 04023060 Vila Clementino, SP, BrazilFour-week-old female Wistar rats were divided into two groups and fed a control diet (C) or a hyperlipidic diet (H) for 4 weeks. Rats from each group underwent ovariectomy (OVX) or sham surgery (SHAM). They received C or H for the next four weeks. The body weight gain (BW), food efficiency (FE), and carcass lipid content were higher in the OVX H than in the SHAM H. The OVX H exhibited a higher serum leptin level than other groups. IL-6, TNF-α, and IL-10 content of mesenteric (MES) adipose tissue was lower in the OVX H than in the OVX C. IL-6, TNF-α, and IL-10 content of retroperitoneal (RET) adipose tissue was lower in the SHAM H than in the SHAM C. The SHAM H showed decreased TG relative to the SHAM C. Similar results were obtained in relation to IL-6Rα, TNFR1, TLR-4, and MyD88 contents in the MES and RET white adipose tissue among the groups. A hyperlipidic diet for 8 weeks combined with short-term ovariectomy decreases the cytokine content of MES adipose tissues but increases BW, enhancing FE and elevating serum leptin levels. These suggest that the absence of estrogens promotes metabolic changes that may contribute to installation of a proinflammatory process induced by a hyperlipidic diet.http://dx.doi.org/10.1155/2015/923248
spellingShingle Nelson Inacio Pinto Neto
Maria Elizabeth Sousa Rodrigues
Ana Claudia Losinskas Hachul
Mayara Franzoi Moreno
Valter Tadeu Boldarine
Eliane Beraldi Ribeiro
Lila Missae Oyama
Claudia Maria Oller do Nascimento
A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
Mediators of Inflammation
title A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
title_full A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
title_fullStr A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
title_full_unstemmed A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
title_short A Hyperlipidic Diet Combined with Short-Term Ovariectomy Increases Adiposity and Hyperleptinemia and Decreases Cytokine Content in Mesenteric Adipose Tissue
title_sort hyperlipidic diet combined with short term ovariectomy increases adiposity and hyperleptinemia and decreases cytokine content in mesenteric adipose tissue
url http://dx.doi.org/10.1155/2015/923248
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