Metabolic syndrome patterns by gender in major depressive disorder.
Major depressive disorder (MDD) and metabolic syndrome (MetS) are significant health challenges, with distinct gender-specific manifestations. This suggests that the clinical presentation of MetS within the MDD cohort may also vary by gender. The objective of this study is to explore these gender-sp...
Saved in:
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2024-01-01
|
| Series: | PLoS ONE |
| Online Access: | https://doi.org/10.1371/journal.pone.0313629 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850246005163819008 |
|---|---|
| author | Lu Li Ling Xiong Zhihua Liu Lin Zhang |
| author_facet | Lu Li Ling Xiong Zhihua Liu Lin Zhang |
| author_sort | Lu Li |
| collection | DOAJ |
| description | Major depressive disorder (MDD) and metabolic syndrome (MetS) are significant health challenges, with distinct gender-specific manifestations. This suggests that the clinical presentation of MetS within the MDD cohort may also vary by gender. The objective of this study is to explore these gender-specific clinical patterns in the co-occurrence of MetS among hospitalized MDD patients, thereby offering insights and guidance for targeted interventions aimed at managing MetS in this demographic. The study included 1,281 first hospitalization MDD patients. Data were collected on socio-demographic characteristics and general clinical profiles. Metabolic parameters, routine biochemical markers, and psychological symptoms were measured and analyzed. The prevalence of MetS was 8.21% in male patients and 10.34% in female patients, with no significant difference between genders. Gender-specific risk factors were identified: in males, age and anxiety symptoms were significant predictors of MetS, while in females, age at onset and married were linked to the development of MetS. Additionally, MetS severity was influenced by age at onset in males and by both age at onset and married in females. This study found no gender-specific prevalence of MetS in hospitalized MDD patients. However, gender-specific factors influencing MetS development and severity highlight the need for focused management in older, married females and older males with high anxiety symptoms. |
| format | Article |
| id | doaj-art-9292e11f30bd4a70aa22d9bd23b049ea |
| institution | OA Journals |
| issn | 1932-6203 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-9292e11f30bd4a70aa22d9bd23b049ea2025-08-20T01:59:17ZengPublic Library of Science (PLoS)PLoS ONE1932-62032024-01-011912e031362910.1371/journal.pone.0313629Metabolic syndrome patterns by gender in major depressive disorder.Lu LiLing XiongZhihua LiuLin ZhangMajor depressive disorder (MDD) and metabolic syndrome (MetS) are significant health challenges, with distinct gender-specific manifestations. This suggests that the clinical presentation of MetS within the MDD cohort may also vary by gender. The objective of this study is to explore these gender-specific clinical patterns in the co-occurrence of MetS among hospitalized MDD patients, thereby offering insights and guidance for targeted interventions aimed at managing MetS in this demographic. The study included 1,281 first hospitalization MDD patients. Data were collected on socio-demographic characteristics and general clinical profiles. Metabolic parameters, routine biochemical markers, and psychological symptoms were measured and analyzed. The prevalence of MetS was 8.21% in male patients and 10.34% in female patients, with no significant difference between genders. Gender-specific risk factors were identified: in males, age and anxiety symptoms were significant predictors of MetS, while in females, age at onset and married were linked to the development of MetS. Additionally, MetS severity was influenced by age at onset in males and by both age at onset and married in females. This study found no gender-specific prevalence of MetS in hospitalized MDD patients. However, gender-specific factors influencing MetS development and severity highlight the need for focused management in older, married females and older males with high anxiety symptoms.https://doi.org/10.1371/journal.pone.0313629 |
| spellingShingle | Lu Li Ling Xiong Zhihua Liu Lin Zhang Metabolic syndrome patterns by gender in major depressive disorder. PLoS ONE |
| title | Metabolic syndrome patterns by gender in major depressive disorder. |
| title_full | Metabolic syndrome patterns by gender in major depressive disorder. |
| title_fullStr | Metabolic syndrome patterns by gender in major depressive disorder. |
| title_full_unstemmed | Metabolic syndrome patterns by gender in major depressive disorder. |
| title_short | Metabolic syndrome patterns by gender in major depressive disorder. |
| title_sort | metabolic syndrome patterns by gender in major depressive disorder |
| url | https://doi.org/10.1371/journal.pone.0313629 |
| work_keys_str_mv | AT luli metabolicsyndromepatternsbygenderinmajordepressivedisorder AT lingxiong metabolicsyndromepatternsbygenderinmajordepressivedisorder AT zhihualiu metabolicsyndromepatternsbygenderinmajordepressivedisorder AT linzhang metabolicsyndromepatternsbygenderinmajordepressivedisorder |