Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model

Combined enriched environment and fluoxetine enhance myelin protein expression in the prefrontal cortex of a chronic unpredictable stress depression model

Abstract Background The primary protein components of white matter include myelin basic protein (MBP) and 2’,3’-cyclic nucleotide 3’-phosphodiesterase (CNP). Alterations in their expression are significantly implicated in depression. This study investigated changes in MBP and CNP expression associat...

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Bibliographic Details
Main Authors: Jingyang Gu, Cong Liu, Yan Li, Laipeng Feng, Mengjun Geng, Jiao Dong, Jinhong Han, Liqin Zhao, Qiujing Shao, Hui-Ying Wang, Chang-Hong Wang
Format: Article
Language:English
Published: BMC 2025-06-01
Series:Behavioral and Brain Functions
Subjects:
Enriched environment
Fluoxetine
Myelin proteins
Prefrontal cortex
Depression
Online Access:https://doi.org/10.1186/s12993-025-00282-1
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