Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective
Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious pathogens and inflammation to a variety of outcomes, including schizophrenia, bipolar disorde...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-01-01
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| Series: | Decoding Infection and Transmission |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2949924024000132 |
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| author | Zhiyang Yin Catherine Gordon Zikai Zhou Minjun Ji Zhipeng Xu |
| author_facet | Zhiyang Yin Catherine Gordon Zikai Zhou Minjun Ji Zhipeng Xu |
| author_sort | Zhiyang Yin |
| collection | DOAJ |
| description | Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious pathogens and inflammation to a variety of outcomes, including schizophrenia, bipolar disorder and autism spectrum disorder. MIA, which is typically triggered by pathogens (such as viruses, bacteria, fungi, and parasites), might offer a new perspective on prenatal NDD pathogenesis, possibly attributed to the altered microbiome of the mother. In this review, we highlight the primary mechanisms underlying MIA-induced NDDs caused by pathogens and/or pathogen-derived agents. Moreover, we outline therapeutic strategies to mitigate pathogen-induced MIA-associated neurological disorders, with the primary goal of preventing or managing pathogen exposure during pregnancy and minimizing the long-term effects on the offspring. |
| format | Article |
| id | doaj-art-928c481a9be942959b29608f9deeb4bb |
| institution | Kabale University |
| issn | 2949-9240 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Decoding Infection and Transmission |
| spelling | doaj-art-928c481a9be942959b29608f9deeb4bb2025-08-20T03:47:10ZengKeAi Communications Co., Ltd.Decoding Infection and Transmission2949-92402024-01-01210002910.1016/j.dcit.2024.100029Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspectiveZhiyang Yin0Catherine Gordon1Zikai Zhou2Minjun Ji3Zhipeng Xu4State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Pathogen Biology, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, PR China; The First Clinical College of Nanjing Medical University, Nanjing, Jiangsu, PR ChinaInfection and Inflammation Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, AustraliaZhongshan Institute for Drug Discovery, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, PR ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Pathogen Biology, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, PR China; NHC Key Laboratory of Antibody Technique, Nanjing Medical University, Nanjing, Jiangsu, PR ChinaState Key Laboratory of Reproductive Medicine and Offspring Health, Department of Pathogen Biology, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, PR China; NHC Key Laboratory of Antibody Technique, Nanjing Medical University, Nanjing, Jiangsu, PR China; Corresponding author. State Key Laboratory of Reproductive Medicine and Offspring Health, Department of Pathogen Biology, Key Laboratory for Infections and Control of Jiangsu Province, Nanjing Medical University, Nanjing, Jiangsu, PR China.Neuropsychiatric disorders (NDDs) have been associated with maternal immune activation (MIA) in epidemiologic studies, such as prospective birth cohort studies. There is evidence linking maternal infectious pathogens and inflammation to a variety of outcomes, including schizophrenia, bipolar disorder and autism spectrum disorder. MIA, which is typically triggered by pathogens (such as viruses, bacteria, fungi, and parasites), might offer a new perspective on prenatal NDD pathogenesis, possibly attributed to the altered microbiome of the mother. In this review, we highlight the primary mechanisms underlying MIA-induced NDDs caused by pathogens and/or pathogen-derived agents. Moreover, we outline therapeutic strategies to mitigate pathogen-induced MIA-associated neurological disorders, with the primary goal of preventing or managing pathogen exposure during pregnancy and minimizing the long-term effects on the offspring.http://www.sciencedirect.com/science/article/pii/S2949924024000132Maternal immune activationNeurodevelopmentVirusBacteriaParasite |
| spellingShingle | Zhiyang Yin Catherine Gordon Zikai Zhou Minjun Ji Zhipeng Xu Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective Decoding Infection and Transmission Maternal immune activation Neurodevelopment Virus Bacteria Parasite |
| title | Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective |
| title_full | Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective |
| title_fullStr | Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective |
| title_full_unstemmed | Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective |
| title_short | Maternal immune activation and neuropsychiatric disease in offspring: Pathogen's perspective |
| title_sort | maternal immune activation and neuropsychiatric disease in offspring pathogen s perspective |
| topic | Maternal immune activation Neurodevelopment Virus Bacteria Parasite |
| url | http://www.sciencedirect.com/science/article/pii/S2949924024000132 |
| work_keys_str_mv | AT zhiyangyin maternalimmuneactivationandneuropsychiatricdiseaseinoffspringpathogensperspective AT catherinegordon maternalimmuneactivationandneuropsychiatricdiseaseinoffspringpathogensperspective AT zikaizhou maternalimmuneactivationandneuropsychiatricdiseaseinoffspringpathogensperspective AT minjunji maternalimmuneactivationandneuropsychiatricdiseaseinoffspringpathogensperspective AT zhipengxu maternalimmuneactivationandneuropsychiatricdiseaseinoffspringpathogensperspective |