Analysis of vascular aging phenotypes in a high cardiovascular risk population
Abstract Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a group with a very high cardiovascular risk according...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2025-06-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-025-04988-0 |
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| author | Dmitrii Usoltsev Ekaterina Moguchaya Maria Boyarinova Ekaterina Kolesova Anastasia Erina Kristina Tolkunova Nadezhda Paskar Asiiat Alieva Elena Vasilyeva Sofia Kibkalo Anna Kostareva Alexandra Konradi Evgeny Shlyakhto Oxana Rotar Mykyta Artomov |
| author_facet | Dmitrii Usoltsev Ekaterina Moguchaya Maria Boyarinova Ekaterina Kolesova Anastasia Erina Kristina Tolkunova Nadezhda Paskar Asiiat Alieva Elena Vasilyeva Sofia Kibkalo Anna Kostareva Alexandra Konradi Evgeny Shlyakhto Oxana Rotar Mykyta Artomov |
| author_sort | Dmitrii Usoltsev |
| collection | DOAJ |
| description | Abstract Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a group with a very high cardiovascular risk according to the SCORE2 scale. A cohort of 618 participants from three metro areas underwent carotid-femoral pulse wave velocity (cfPWV) assessment between 2012 and 2018, with biannual follow-ups to record cardiovascular events and mortality. We compared our data with findings from previously published European cohorts to evaluate methods for classifying vascular aging phenotypes. Our findings indicate that definitions designed for low- and medium-risk populations are of limited use in high-risk groups. Moreover, the association between elevated cfPWV and increased overall mortality suggests a potential selection pressure on vascular aging phenotypes. These insights advance the development of predictive biomarkers for cardiovascular risk in populations with high rates of cardiovascular disease. |
| format | Article |
| id | doaj-art-928bdecc3db94eeebbbdaff2d2d418b3 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj-art-928bdecc3db94eeebbbdaff2d2d418b32025-08-20T03:26:42ZengNature PortfolioScientific Reports2045-23222025-06-011511710.1038/s41598-025-04988-0Analysis of vascular aging phenotypes in a high cardiovascular risk populationDmitrii Usoltsev0Ekaterina Moguchaya1Maria Boyarinova2Ekaterina Kolesova3Anastasia Erina4Kristina Tolkunova5Nadezhda Paskar6Asiiat Alieva7Elena Vasilyeva8Sofia Kibkalo9Anna Kostareva10Alexandra Konradi11Evgeny Shlyakhto12Oxana Rotar13Mykyta Artomov14Almazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreAlmazov National Medical Research CentreThe Institute for Genomic Medicine, Nationwide Children’s HospitalAbstract Changes in the vascular system associated with aging contribute to conditions such as hypertension and atherosclerosis. In this study, we explored the prevalence and survival effects of vascular aging phenotypes in a Russian population, a group with a very high cardiovascular risk according to the SCORE2 scale. A cohort of 618 participants from three metro areas underwent carotid-femoral pulse wave velocity (cfPWV) assessment between 2012 and 2018, with biannual follow-ups to record cardiovascular events and mortality. We compared our data with findings from previously published European cohorts to evaluate methods for classifying vascular aging phenotypes. Our findings indicate that definitions designed for low- and medium-risk populations are of limited use in high-risk groups. Moreover, the association between elevated cfPWV and increased overall mortality suggests a potential selection pressure on vascular aging phenotypes. These insights advance the development of predictive biomarkers for cardiovascular risk in populations with high rates of cardiovascular disease.https://doi.org/10.1038/s41598-025-04988-0 |
| spellingShingle | Dmitrii Usoltsev Ekaterina Moguchaya Maria Boyarinova Ekaterina Kolesova Anastasia Erina Kristina Tolkunova Nadezhda Paskar Asiiat Alieva Elena Vasilyeva Sofia Kibkalo Anna Kostareva Alexandra Konradi Evgeny Shlyakhto Oxana Rotar Mykyta Artomov Analysis of vascular aging phenotypes in a high cardiovascular risk population Scientific Reports |
| title | Analysis of vascular aging phenotypes in a high cardiovascular risk population |
| title_full | Analysis of vascular aging phenotypes in a high cardiovascular risk population |
| title_fullStr | Analysis of vascular aging phenotypes in a high cardiovascular risk population |
| title_full_unstemmed | Analysis of vascular aging phenotypes in a high cardiovascular risk population |
| title_short | Analysis of vascular aging phenotypes in a high cardiovascular risk population |
| title_sort | analysis of vascular aging phenotypes in a high cardiovascular risk population |
| url | https://doi.org/10.1038/s41598-025-04988-0 |
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