Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension
Background Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleuki...
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Thieme Revinter Publicações
2022-10-01
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| Series: | Arquivos de Neuro-Psiquiatria |
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| Online Access: | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758559 |
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| author | Ahmet Dündar Adalet Arıkanoğlu Hasan Hüseyin Özdemir Hamza Aslanhan Mehmet Uğur Çevik |
| author_facet | Ahmet Dündar Adalet Arıkanoğlu Hasan Hüseyin Özdemir Hamza Aslanhan Mehmet Uğur Çevik |
| author_sort | Ahmet Dündar |
| collection | DOAJ |
| description | Background Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes.
Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH.
Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured.
Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease.
Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process. |
| format | Article |
| id | doaj-art-928afb78cdba4d9c8b424d8fab8d22bd |
| institution | OA Journals |
| issn | 0004-282X 1678-4227 |
| language | English |
| publishDate | 2022-10-01 |
| publisher | Thieme Revinter Publicações |
| record_format | Article |
| series | Arquivos de Neuro-Psiquiatria |
| spelling | doaj-art-928afb78cdba4d9c8b424d8fab8d22bd2025-08-20T01:58:34ZengThieme Revinter PublicaçõesArquivos de Neuro-Psiquiatria0004-282X1678-42272022-10-0180101011101610.1055/s-0042-1758559Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertensionAhmet Dündar0Adalet Arıkanoğlu1Hasan Hüseyin Özdemir2Hamza Aslanhan3Mehmet Uğur Çevik4Mardin Artuklu University, Vocational School of Health Services, Department of Medical Laboratory, Mardin, Turkey.Dicle University, Faculty of Medicine, Department of Neurology, Diyarbakır, Turkey.A Hospital, Department of Neurology, İstanbul, Turkey.Dicle University, Faculty of Medicine, Department of Family Medicine, Diyarbakır, Turkey.Dicle University, Faculty of Medicine, Department of Neurology, Diyarbakır, Turkey.Background Idiopathic intracranial hypertension (IIH) is characterized by increased cerebrospinal fluid (CSF) pressure of unknown cause. It has been suggested that the inflammatory process plays a role in the pathophysiology of the disease. Sortilin-1, lipocalin-2, autotaxin, decorin, and interleukin-33 (IL-33) are among the factors involved in inflammatory processes. Objective To investigate the CSF levels of sortilin-1, lipocalin-2, autotaxin, decorin, and IL-33 in patients with IIH. Methods A total of 24 IIH patients and 21 healthy controls were included in the study. Demographic characteristics of the patients and of the control group as well as CSF pressures were evaluated. Sortilin-1, lipocalin-2, autotaxin, decorin and IL-33 levels in the CSF were measured. Results The CSF levels lipocalin-2, sortilin-1, autotaxin, IL-33 and CSF pressure were significantly higher in the patients group compared with the control group (p < 0.001). Decorin levels were reduced in patients (p < 0.05). There was no correlation between the autotaxin and IL-33 levels and age, gender, CSF pressure, and body mass index. The results of our study showed that inflammatory activation plays an important role in the development of the pathophysiology of IIH. In addition, the fact that the markers used in our study have never been studied in the etiopathogenesis of IIH is important in explaining the molecular mechanism of this disease. Conclusion Studies are needed to evaluate the role of these cytokines in the pathophysiology of the disease. It is necessary to evaluate the effects of these molecules on this process.http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758559pseudotumor cerebrilipocalin-2decorininterleukin-33sortilin-1autotaxin |
| spellingShingle | Ahmet Dündar Adalet Arıkanoğlu Hasan Hüseyin Özdemir Hamza Aslanhan Mehmet Uğur Çevik Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension Arquivos de Neuro-Psiquiatria pseudotumor cerebri lipocalin-2 decorin interleukin-33 sortilin-1 autotaxin |
| title | Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension |
| title_full | Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension |
| title_fullStr | Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension |
| title_full_unstemmed | Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension |
| title_short | Cerebrospinal fluid levels of sortilin-1, lipocalin-2, autotaxin, decorin and interleukin-33 in patients with idiopathic intracranial hypertension |
| title_sort | cerebrospinal fluid levels of sortilin 1 lipocalin 2 autotaxin decorin and interleukin 33 in patients with idiopathic intracranial hypertension |
| topic | pseudotumor cerebri lipocalin-2 decorin interleukin-33 sortilin-1 autotaxin |
| url | http://www.thieme-connect.de/DOI/DOI?10.1055/s-0042-1758559 |
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