The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy
Immunometabolism has received significant interest as a field exploring the dynamic interation between the immune system and metabolic processes. Immune cell activation, proliferation, and function are tightly regulated by metabolism, and metabolic products influence immune responses. These two aspe...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-07-01
|
| Series: | Pharmacological Research |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1043661825002282 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1850111167180046336 |
|---|---|
| author | Xin Zhou Ning-ning Shan |
| author_facet | Xin Zhou Ning-ning Shan |
| author_sort | Xin Zhou |
| collection | DOAJ |
| description | Immunometabolism has received significant interest as a field exploring the dynamic interation between the immune system and metabolic processes. Immune cell activation, proliferation, and function are tightly regulated by metabolism, and metabolic products influence immune responses. These two aspects interact to maintain internal homeostasis. Disruption of immunometabolism plays a crucial role in the onset and progression of autoimmune diseases. Metabolic abnormalities may cause abnormal activation and differentiation of immune cells, leading to attacks on self-tissues. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by platelet dysfunction and impaired production, which are closely related to metabolic dysfunction. Alterations in glycolysis, fatty acid oxidation, and amino acid metabolism affect platelet function and immune cell behavior, contributing to disease progression. This review discusses the role of immunometabolism in ITP, highlights recent advances in diagnosis and treatment, and explores potential therapeutic strategies. |
| format | Article |
| id | doaj-art-92899b2cbccc449e8c6fdea6fb747cbb |
| institution | OA Journals |
| issn | 1096-1186 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pharmacological Research |
| spelling | doaj-art-92899b2cbccc449e8c6fdea6fb747cbb2025-08-20T02:37:39ZengElsevierPharmacological Research1096-11862025-07-0121710780310.1016/j.phrs.2025.107803The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapyXin Zhou0Ning-ning Shan1Department of Haematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, ChinaCorrespondence to: Department of Haematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, 324 Jing Wu Rd, Jinan, Shandong 250021, China.; Department of Haematology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, ChinaImmunometabolism has received significant interest as a field exploring the dynamic interation between the immune system and metabolic processes. Immune cell activation, proliferation, and function are tightly regulated by metabolism, and metabolic products influence immune responses. These two aspects interact to maintain internal homeostasis. Disruption of immunometabolism plays a crucial role in the onset and progression of autoimmune diseases. Metabolic abnormalities may cause abnormal activation and differentiation of immune cells, leading to attacks on self-tissues. Immune thrombocytopenia (ITP) is an autoimmune disease characterized by platelet dysfunction and impaired production, which are closely related to metabolic dysfunction. Alterations in glycolysis, fatty acid oxidation, and amino acid metabolism affect platelet function and immune cell behavior, contributing to disease progression. This review discusses the role of immunometabolism in ITP, highlights recent advances in diagnosis and treatment, and explores potential therapeutic strategies.http://www.sciencedirect.com/science/article/pii/S1043661825002282ImmunometabolismITPGlycolysisMetabolic Reprogramming |
| spellingShingle | Xin Zhou Ning-ning Shan The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy Pharmacological Research Immunometabolism ITP Glycolysis Metabolic Reprogramming |
| title | The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy |
| title_full | The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy |
| title_fullStr | The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy |
| title_full_unstemmed | The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy |
| title_short | The metabolism-immunity axis in Immune thrombocytopenia: from energy regulation to targeted therapy |
| title_sort | metabolism immunity axis in immune thrombocytopenia from energy regulation to targeted therapy |
| topic | Immunometabolism ITP Glycolysis Metabolic Reprogramming |
| url | http://www.sciencedirect.com/science/article/pii/S1043661825002282 |
| work_keys_str_mv | AT xinzhou themetabolismimmunityaxisinimmunethrombocytopeniafromenergyregulationtotargetedtherapy AT ningningshan themetabolismimmunityaxisinimmunethrombocytopeniafromenergyregulationtotargetedtherapy AT xinzhou metabolismimmunityaxisinimmunethrombocytopeniafromenergyregulationtotargetedtherapy AT ningningshan metabolismimmunityaxisinimmunethrombocytopeniafromenergyregulationtotargetedtherapy |