Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions
Zinc‐modified cobalt‐based metal–organic frameworks (ZCM) can effectively generate abundant reactive oxygen species to heal bacterially infected wounds. However, their instability under physiological conditions not only weakens its catalytic function but also leads to the accumulation of large amoun...
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| Format: | Article |
| Language: | English |
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Wiley-VCH
2025-08-01
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| Series: | Small Structures |
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| Online Access: | https://doi.org/10.1002/sstr.202500068 |
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| author | Xianchun Fu Han Zhang Zhi Liu Li Yu Yongtao Zhang Changyao Wang |
| author_facet | Xianchun Fu Han Zhang Zhi Liu Li Yu Yongtao Zhang Changyao Wang |
| author_sort | Xianchun Fu |
| collection | DOAJ |
| description | Zinc‐modified cobalt‐based metal–organic frameworks (ZCM) can effectively generate abundant reactive oxygen species to heal bacterially infected wounds. However, their instability under physiological conditions not only weakens its catalytic function but also leads to the accumulation of large amounts of metal ions, thereby increasing the possibility of new wound infections. In this study, synergistic antibacterial nanoparticles (ZCMCC) are synthesized by loading chlorogenic acid (CGA) on ZCM with chitosan modification to increase the presence of carboxyl groups in the structure and enhance its stability. Meanwhile, ZCMCC exerted broad‐spectrum antibacterial activities against Gram‐negative bacteria (Escherichia coli, 98%), Gram‐positive bacteria (Staphylococcus aureus, 99.4%), and methicillin‐resistant S. aureus (99.3%) by chemodynamic therapy and the release of CGA. Importantly, ZCMCC not only promotes the healing of infected wounds by increasing the expression of the vascular endothelial growth factor α but also targets the infective areas by combining with the CD44. Hence, this research presents a novel approach for creating a synergistic antibacterial system and developing targeted therapies for deep tissue/organ infections in the future. |
| format | Article |
| id | doaj-art-9288cfdc365e4e64829455bda7ec3de1 |
| institution | Kabale University |
| issn | 2688-4062 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Wiley-VCH |
| record_format | Article |
| series | Small Structures |
| spelling | doaj-art-9288cfdc365e4e64829455bda7ec3de12025-08-20T03:59:25ZengWiley-VCHSmall Structures2688-40622025-08-0168n/an/a10.1002/sstr.202500068Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological ConditionsXianchun Fu0Han Zhang1Zhi Liu2Li Yu3Yongtao Zhang4Changyao Wang5Department of Urology The Affiliated Hospital of Qingdao University Qingdao 266003 ChinaDepartment of Orthopedics The Affiliated Hospital of Qingdao University Qingdao 266003 ChinaDepartment of Urology The First Affiliated Hospital of University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230001 ChinaDepartment of Radiation Oncology The Affiliated Hospital of Qingdao University Qingdao 266003 ChinaDepartment of Orthopedics The Affiliated Hospital of Qingdao University Qingdao 266003 ChinaDepartment of Orthopedics The Affiliated Hospital of Qingdao University Qingdao 266003 ChinaZinc‐modified cobalt‐based metal–organic frameworks (ZCM) can effectively generate abundant reactive oxygen species to heal bacterially infected wounds. However, their instability under physiological conditions not only weakens its catalytic function but also leads to the accumulation of large amounts of metal ions, thereby increasing the possibility of new wound infections. In this study, synergistic antibacterial nanoparticles (ZCMCC) are synthesized by loading chlorogenic acid (CGA) on ZCM with chitosan modification to increase the presence of carboxyl groups in the structure and enhance its stability. Meanwhile, ZCMCC exerted broad‐spectrum antibacterial activities against Gram‐negative bacteria (Escherichia coli, 98%), Gram‐positive bacteria (Staphylococcus aureus, 99.4%), and methicillin‐resistant S. aureus (99.3%) by chemodynamic therapy and the release of CGA. Importantly, ZCMCC not only promotes the healing of infected wounds by increasing the expression of the vascular endothelial growth factor α but also targets the infective areas by combining with the CD44. Hence, this research presents a novel approach for creating a synergistic antibacterial system and developing targeted therapies for deep tissue/organ infections in the future.https://doi.org/10.1002/sstr.202500068antibacterialsdisintegrationsmetal–organic frameworksreactive oxygen specieswound healing |
| spellingShingle | Xianchun Fu Han Zhang Zhi Liu Li Yu Yongtao Zhang Changyao Wang Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions Small Structures antibacterials disintegrations metal–organic frameworks reactive oxygen species wound healing |
| title | Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions |
| title_full | Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions |
| title_fullStr | Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions |
| title_full_unstemmed | Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions |
| title_short | Right Once for All: Inflammation‐Targeted Zinc–Cobalt Metal–Organic Framework Nanozymes with High Stability and Broad‐Spectrum Synergistic Antibacterial Properties for Accelerating Bacteria‐Infected Wound Healing under Physiological Conditions |
| title_sort | right once for all inflammation targeted zinc cobalt metal organic framework nanozymes with high stability and broad spectrum synergistic antibacterial properties for accelerating bacteria infected wound healing under physiological conditions |
| topic | antibacterials disintegrations metal–organic frameworks reactive oxygen species wound healing |
| url | https://doi.org/10.1002/sstr.202500068 |
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