CpG‐Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2‐Mediated Remodeling of Tumor‐Associated Macrophages

CpG‐Based Nanovaccines Enhance Ovarian Cancer Immune Response by Gbp2‐Mediated Remodeling of Tumor‐Associated Macrophages

Abstract CpG oligodeoxynucleotides (CpG), as an immunoadjuvant, can facilitate the transformation of tumor‐associated macrophages (TAMs)into tumoricidal M1 macrophages. However, the accumulation of free CpG in tumor tissues remains a substantial challenge. To address this, a nanovaccine (PLGA‐CpG@ID...

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Main Authors: Jiaqiang Xiong, Juyuan Huang, Hanxiao Xu, Qiuji Wu, Jiahui Zhao, Yurou Chen, Guanlan Fan, Haotong Guan, Rourou Xiao, Zhaojin He, Siqi Wu, Wenliang Ouyang, Shixuan Wang, Lu Zhang, Peng Xia, Wei Zhang, Meng Wu
Format: Article
Language:English
Published: Wiley 2025-04-01
Series:Advanced Science
Subjects:
Gbp2
immunotherapy
nanovaccine
ovarian cancer
TAMs
Online Access:https://doi.org/10.1002/advs.202412881
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