Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery
The aim of this investigation was to compare the clinical effects and pharmacokinetics of lidocaine (one metabolite) and mepivacaine (two metabolites) in 2 groups of 15 patients undergoing axillary brachial plexus anaesthesia. The study had a randomised design. The 30 patients were divided into 2 gr...
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| Format: | Article |
| Language: | English |
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Wiley
2002-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1100/tsw.2002.180 |
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| author | Marc A. M. Simon Tom B. Vree Mathieu J.M. Gielen Leo H.D.J. Booij Aart J. Lagerwerf |
| author_facet | Marc A. M. Simon Tom B. Vree Mathieu J.M. Gielen Leo H.D.J. Booij Aart J. Lagerwerf |
| author_sort | Marc A. M. Simon |
| collection | DOAJ |
| description | The aim of this investigation was to compare the clinical effects and pharmacokinetics of lidocaine (one metabolite) and mepivacaine (two metabolites) in 2 groups of 15 patients undergoing axillary brachial plexus anaesthesia. The study had a randomised design. The 30 patients were divided into 2 groups. The patients received either lidocaine (600 mg = 2.561 mMol + 5 μg ml-1 adrenaline) or mepivacaine (600 mg = 2.436 mMol + 5 μg ml-1 adrenaline), injected via the axilla near the brachial plexus over a period of 30 s. Onset of surgical analgesia was defined as the period from the end of the local anaesthetic injection to the loss of pinprick sensation in the distribution of the ulnar, radial, and median nerve. Motor block was measured. Onset of motor block was similar for both drugs. Lidocaine is eliminated biexponentially with a t1/2α of 9.95 ± 14.3 min and a t1/2β of 2.86 α 1.55 h. Lidocaine is metabolised into MEGX (tmax 2.31 α 0.84 h; Cmax 0.32 α 0.13 mg l-1; t1/2β 2.36 α 2.35 h; total body clearance was 67.9 α 28.9 l h-1). |
| format | Article |
| id | doaj-art-9281f3df0cfd43a2ab50134b1a5c68b4 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2002-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-9281f3df0cfd43a2ab50134b1a5c68b42025-08-20T03:20:37ZengWileyThe Scientific World Journal1537-744X2002-01-0121306131910.1100/tsw.2002.180Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case SurgeryMarc A. M. Simon0Tom B. Vree1Mathieu J.M. Gielen2Leo H.D.J. Booij3Aart J. Lagerwerf4Department of Anaesthesiology, Medisch Spectrum Twente, Haaksbergerstraat 55, 7513 ER Enschede, NetherlandsInstitute for Anaesthesiology, Academic Hospital Nijmegen Sint Radboud, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, NetherlandsInstitute for Anaesthesiology, Academic Hospital Nijmegen Sint Radboud, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, NetherlandsInstitute for Anaesthesiology, Academic Hospital Nijmegen Sint Radboud, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, NetherlandsInstitute for Anaesthesiology, Academic Hospital Nijmegen Sint Radboud, Geert Grooteplein Zuid 10, 6525 GA Nijmegen, NetherlandsThe aim of this investigation was to compare the clinical effects and pharmacokinetics of lidocaine (one metabolite) and mepivacaine (two metabolites) in 2 groups of 15 patients undergoing axillary brachial plexus anaesthesia. The study had a randomised design. The 30 patients were divided into 2 groups. The patients received either lidocaine (600 mg = 2.561 mMol + 5 μg ml-1 adrenaline) or mepivacaine (600 mg = 2.436 mMol + 5 μg ml-1 adrenaline), injected via the axilla near the brachial plexus over a period of 30 s. Onset of surgical analgesia was defined as the period from the end of the local anaesthetic injection to the loss of pinprick sensation in the distribution of the ulnar, radial, and median nerve. Motor block was measured. Onset of motor block was similar for both drugs. Lidocaine is eliminated biexponentially with a t1/2α of 9.95 ± 14.3 min and a t1/2β of 2.86 α 1.55 h. Lidocaine is metabolised into MEGX (tmax 2.31 α 0.84 h; Cmax 0.32 α 0.13 mg l-1; t1/2β 2.36 α 2.35 h; total body clearance was 67.9 α 28.9 l h-1).http://dx.doi.org/10.1100/tsw.2002.180 |
| spellingShingle | Marc A. M. Simon Tom B. Vree Mathieu J.M. Gielen Leo H.D.J. Booij Aart J. Lagerwerf Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery The Scientific World Journal |
| title | Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery |
| title_full | Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery |
| title_fullStr | Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery |
| title_full_unstemmed | Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery |
| title_short | Similar Motor Block Effects and Disposition Kinetics between Lidocaine and (±)Mepivacaine in Patients Undergoing Axillary Brachial Plexus Block during Day Case Surgery |
| title_sort | similar motor block effects and disposition kinetics between lidocaine and mepivacaine in patients undergoing axillary brachial plexus block during day case surgery |
| url | http://dx.doi.org/10.1100/tsw.2002.180 |
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