A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health
Background/Purpose: This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling and root planing in patients with chronic gingivitis. Materials and methods: The participants were randomly assigned to one of two treatment groups: th...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Journal of Oral Biology and Craniofacial Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2212426821001159 |
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| author | Sneha Singh Anootpal Gogoi Ashish Kumar Eesha, Dr. Rinku Jagnade Gaurav Jain Sanjay Rastogi Sanjay Dutta |
| author_facet | Sneha Singh Anootpal Gogoi Ashish Kumar Eesha, Dr. Rinku Jagnade Gaurav Jain Sanjay Rastogi Sanjay Dutta |
| author_sort | Sneha Singh |
| collection | DOAJ |
| description | Background/Purpose: This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling and root planing in patients with chronic gingivitis. Materials and methods: The participants were randomly assigned to one of two treatment groups: the experimental group (n = 50), which received 10 mg of Lycopene a day for two weeks, or the control group (n = 50) received a placebo for two weeks. For each category, quadrant distribution was randomized, with two quadrants receiving oral prophylaxis (OP) and two quadrants receiving no care (non-OP). At baseline, 1st, and 2nd weeks, the sulcus bleeding index, plaque index, gingival index, and salivary uric acid level were measured. Results: All clinical criteria, including SBI, PI, GI, and salivary uric acid levels, showed a statistically significant decline in all patient types. Both clinical parameters were significantly reduced (p < 0.001) in the OP-lycopene group relative to the non-OP-placebo group and non-OP lycopene group (p < 0.05). The PI value in the OP-lycopene group was statistically significantly lower (p < 0.001) than in the non-OP-placebo group; there was no statistically significant difference in the other groups. Salivary uric acid levels in the OP- and non-OP- lycopene groups were significantly lower (p < 0.001) than in the non-OP-placebo population. Conclusion: Based on the findings of this study, Lycopene seems to have a bright future as a treatment option for plaque-induced generalized chronic marginal gingivitis. More research with a broad sample size and multicentre trials is required. Clinical relevance: The article reveals the positive relationship between Lycopene and gingivitis. The analysis shows that a combination of systemically administered Lycopene with oral prophylaxis can be a valuable tool in treating chronic gingivitis and controlling respiratory oxidative stress. |
| format | Article |
| id | doaj-art-9281de5384174b84b2147c4e6c977315 |
| institution | OA Journals |
| issn | 2212-4268 |
| language | English |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Oral Biology and Craniofacial Research |
| spelling | doaj-art-9281de5384174b84b2147c4e6c9773152025-08-20T02:02:02ZengElsevierJournal of Oral Biology and Craniofacial Research2212-42682022-01-01121222610.1016/j.jobcr.2021.09.020A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal healthSneha Singh0Anootpal Gogoi1Ashish Kumar2 Eesha, Dr.3Rinku Jagnade4Gaurav Jain5Sanjay Rastogi6Sanjay Dutta7Dept. of Periodontology, Mithila Minority Dental College and Hospital, IndiaDept. of Periodontology, Regional Dental College, Guwahati, Assam, IndiaDept. of Public Health Dentistry, Baba Jaswant Singh Dental College & Hospital, Ludhiana, IndiaDept. of Oral Pathology, Regional Dental College, Guwahati, Assam, IndiaDept. of Periodontology, Index Institute of Dental Sciences and Research Center, Indore, MP, IndiaDept. of Conservative Dentistry and Endodontics, Saraswati Dental College, Lucknow, Uttar Pradesh, IndiaDept. of Oral and Maxillofacial Surgery, Regional Dental College, Bhangagarh Guwahati, Assam, 781032, India; Corresponding author.Dept. of Oral Medicine and Radiology, Regional Dental College, Bhangagarh Guwahati, Assam, 781032, IndiaBackground/Purpose: This research aimed to compare the effects of systemically prescribed Lycopene as a monotherapy and as an alternative to scaling and root planing in patients with chronic gingivitis. Materials and methods: The participants were randomly assigned to one of two treatment groups: the experimental group (n = 50), which received 10 mg of Lycopene a day for two weeks, or the control group (n = 50) received a placebo for two weeks. For each category, quadrant distribution was randomized, with two quadrants receiving oral prophylaxis (OP) and two quadrants receiving no care (non-OP). At baseline, 1st, and 2nd weeks, the sulcus bleeding index, plaque index, gingival index, and salivary uric acid level were measured. Results: All clinical criteria, including SBI, PI, GI, and salivary uric acid levels, showed a statistically significant decline in all patient types. Both clinical parameters were significantly reduced (p < 0.001) in the OP-lycopene group relative to the non-OP-placebo group and non-OP lycopene group (p < 0.05). The PI value in the OP-lycopene group was statistically significantly lower (p < 0.001) than in the non-OP-placebo group; there was no statistically significant difference in the other groups. Salivary uric acid levels in the OP- and non-OP- lycopene groups were significantly lower (p < 0.001) than in the non-OP-placebo population. Conclusion: Based on the findings of this study, Lycopene seems to have a bright future as a treatment option for plaque-induced generalized chronic marginal gingivitis. More research with a broad sample size and multicentre trials is required. Clinical relevance: The article reveals the positive relationship between Lycopene and gingivitis. The analysis shows that a combination of systemically administered Lycopene with oral prophylaxis can be a valuable tool in treating chronic gingivitis and controlling respiratory oxidative stress.http://www.sciencedirect.com/science/article/pii/S2212426821001159Chronic gingivitisLycopeneROSOral prophylaxisPlacebo |
| spellingShingle | Sneha Singh Anootpal Gogoi Ashish Kumar Eesha, Dr. Rinku Jagnade Gaurav Jain Sanjay Rastogi Sanjay Dutta A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health Journal of Oral Biology and Craniofacial Research Chronic gingivitis Lycopene ROS Oral prophylaxis Placebo |
| title | A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health |
| title_full | A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health |
| title_fullStr | A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health |
| title_full_unstemmed | A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health |
| title_short | A randomized, double-blind, split-mouth controlled clinical trial of systemically administered Lycopene on periodontal health |
| title_sort | randomized double blind split mouth controlled clinical trial of systemically administered lycopene on periodontal health |
| topic | Chronic gingivitis Lycopene ROS Oral prophylaxis Placebo |
| url | http://www.sciencedirect.com/science/article/pii/S2212426821001159 |
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