Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats
Rhaphidophora pinnata, a plant traditionally recognized for its wound-healing properties, contains active compounds such as megastigmane glycosides and damascenone, known for their anti-inflammatory effects. To enhance efficacy and user comfort, this study focused on developing an R. pinnata leaf e...
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Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya
2025-05-01
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| Series: | Borneo Journal of Pharmacy |
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| Online Access: | https://journal.umpr.ac.id/index.php/bjop/article/view/7525 |
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| author | Fathnur Sani Kasmadi Ave Olivia Rahman Havizur Rahman Yuliawati Yuliawati Agung Giri Samudra |
| author_facet | Fathnur Sani Kasmadi Ave Olivia Rahman Havizur Rahman Yuliawati Yuliawati Agung Giri Samudra |
| author_sort | Fathnur Sani Kasmadi |
| collection | DOAJ |
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Rhaphidophora pinnata, a plant traditionally recognized for its wound-healing properties, contains active compounds such as megastigmane glycosides and damascenone, known for their anti-inflammatory effects. To enhance efficacy and user comfort, this study focused on developing an R. pinnata leaf extract nanoparticle gel. Previous research from our group highlighted the significant wound-healing potential of a conventional R. pinnata gel. This present study aimed to evaluate the wound-healing efficacy of a novel R. pinnata nanoparticle gel in male Wistar rats, specifically investigating the impact of nanotechnology application. Nanoparticles were successfully formulated via the ionic gelation method, utilizing 0.250 g of R. pinnata extract, 0.1% chitosan, 0.2% sodium tripolyphosphate, and 0.5% Tween 80. Characterization revealed an average nanoparticle size of 165.70±42.76 nm with a zeta potential of 22.0±1.83 mV. The wound-healing efficacy was assessed across five treatment groups: a positive control (Bioplasenton®), a plain gel base (Formula 0), and nanoparticle gels at 0.5% (Formula I), 1% (Formula II), and 1.5% (Formula III) extract concentrations. Statistical analysis using one-way ANOVA (p <0.05) demonstrated a significant difference in incision wound healing across the groups. Formula III, containing 1.5% R. pinnata nanoparticle extract, exhibited the most superior wound-healing effect, achieving 100% inhibition by day 14, elevated hydroxyproline levels (59 µg/mL), and histologically confirmed excellent skin tissue repair. Formulas II and I followed in efficacy. These compelling findings underscore the significant potential of utilizing nanotechnology in the development of topical preparations for accelerated and effective wound healing.
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| format | Article |
| id | doaj-art-926c9eecedf24e328ecd5101a84a1b4a |
| institution | DOAJ |
| issn | 2621-4814 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | Institute for Researches and Community Services Universitas Muhammadiyah Palangkaraya |
| record_format | Article |
| series | Borneo Journal of Pharmacy |
| spelling | doaj-art-926c9eecedf24e328ecd5101a84a1b4a2025-08-20T03:21:47ZengInstitute for Researches and Community Services Universitas Muhammadiyah PalangkarayaBorneo Journal of Pharmacy2621-48142025-05-018210.33084/bjop.v8i2.7525Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male RatsFathnur Sani Kasmadi0Ave Olivia Rahman1Havizur Rahman2Yuliawati Yuliawati3Agung Giri Samudra4Jambi UniversityJambi UniversityJambi UniversityJambi UniversityUniversity of Bengkulu Rhaphidophora pinnata, a plant traditionally recognized for its wound-healing properties, contains active compounds such as megastigmane glycosides and damascenone, known for their anti-inflammatory effects. To enhance efficacy and user comfort, this study focused on developing an R. pinnata leaf extract nanoparticle gel. Previous research from our group highlighted the significant wound-healing potential of a conventional R. pinnata gel. This present study aimed to evaluate the wound-healing efficacy of a novel R. pinnata nanoparticle gel in male Wistar rats, specifically investigating the impact of nanotechnology application. Nanoparticles were successfully formulated via the ionic gelation method, utilizing 0.250 g of R. pinnata extract, 0.1% chitosan, 0.2% sodium tripolyphosphate, and 0.5% Tween 80. Characterization revealed an average nanoparticle size of 165.70±42.76 nm with a zeta potential of 22.0±1.83 mV. The wound-healing efficacy was assessed across five treatment groups: a positive control (Bioplasenton®), a plain gel base (Formula 0), and nanoparticle gels at 0.5% (Formula I), 1% (Formula II), and 1.5% (Formula III) extract concentrations. Statistical analysis using one-way ANOVA (p <0.05) demonstrated a significant difference in incision wound healing across the groups. Formula III, containing 1.5% R. pinnata nanoparticle extract, exhibited the most superior wound-healing effect, achieving 100% inhibition by day 14, elevated hydroxyproline levels (59 µg/mL), and histologically confirmed excellent skin tissue repair. Formulas II and I followed in efficacy. These compelling findings underscore the significant potential of utilizing nanotechnology in the development of topical preparations for accelerated and effective wound healing. https://journal.umpr.ac.id/index.php/bjop/article/view/7525Wound HealingGelNanoparticleRhaphidophora pinnata |
| spellingShingle | Fathnur Sani Kasmadi Ave Olivia Rahman Havizur Rahman Yuliawati Yuliawati Agung Giri Samudra Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats Borneo Journal of Pharmacy Wound Healing Gel Nanoparticle Rhaphidophora pinnata |
| title | Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats |
| title_full | Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats |
| title_fullStr | Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats |
| title_full_unstemmed | Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats |
| title_short | Wound Healing Activity of Gel Nanoparticles of Rhaphidophora pinnnata Leaves Extract in Male Rats |
| title_sort | wound healing activity of gel nanoparticles of rhaphidophora pinnnata leaves extract in male rats |
| topic | Wound Healing Gel Nanoparticle Rhaphidophora pinnata |
| url | https://journal.umpr.ac.id/index.php/bjop/article/view/7525 |
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