Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study
BackgroundVisceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and female infertility remains ambiguous.MethodsThis study employed a cross-sectional design and analyzed data from the National Health and Nutrition Ex...
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Frontiers Media S.A.
2024-12-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1488309/full |
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| author | Dongli Guo Ruiya Wang |
| author_facet | Dongli Guo Ruiya Wang |
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| description | BackgroundVisceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and female infertility remains ambiguous.MethodsThis study employed a cross-sectional design and analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2012–2016). Weighted logistic regression models were utilized to examine the association between VAT surrogates and infertility. Furthermore, Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the diagnostic efficacy of these surrogates for infertility.ResultsIndividuals experiencing infertility exhibited markedly elevated levels of the Chinese Visceral Adiposity Index (CVAI) (108.30 vs. 69.86, P<0.001) and Visceral Adiposity Index (VAI) (1.68 vs. 1.35, P<0.001). When considered as a continuous variable, CVAI (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.03-1.09, P<0.001), rather than VAI (OR:1.02, 95%CI: 0.98-1.06, P=0.259), demonstrated a significant association with the risk of female infertility. Consistent findings were also evident after dividing participants into 4 subgroups based on CVAI quartiles. Additionally, ROC curves indicated that CVAI exhibited the most robust diagnostic value for female infertility compared to other indices. Subgroup analyses revealed a robust association between CVAI and infertility across different populations.ConclusionFemales with elevated CVAI levels faced a significantly heightened risk of infertility in the United States. CVAI holds promise as a valuable tool for stratifying the risk of infertility. |
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| issn | 1664-2392 |
| language | English |
| publishDate | 2024-12-01 |
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| spelling | doaj-art-926bbc7eefb84aa7a19a74bc9f595a9d2025-08-20T01:59:01ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-12-011510.3389/fendo.2024.14883091488309Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional studyDongli GuoRuiya WangBackgroundVisceral adipose tissue (VAT) exerts a substantial influence on female infertility. Nevertheless, the relationship between VAT surrogates and female infertility remains ambiguous.MethodsThis study employed a cross-sectional design and analyzed data from the National Health and Nutrition Examination Survey (NHANES, 2012–2016). Weighted logistic regression models were utilized to examine the association between VAT surrogates and infertility. Furthermore, Receiver Operating Characteristic (ROC) curve analysis was conducted to assess the diagnostic efficacy of these surrogates for infertility.ResultsIndividuals experiencing infertility exhibited markedly elevated levels of the Chinese Visceral Adiposity Index (CVAI) (108.30 vs. 69.86, P<0.001) and Visceral Adiposity Index (VAI) (1.68 vs. 1.35, P<0.001). When considered as a continuous variable, CVAI (odds ratio [OR]: 1.06, 95% confidence interval [CI]: 1.03-1.09, P<0.001), rather than VAI (OR:1.02, 95%CI: 0.98-1.06, P=0.259), demonstrated a significant association with the risk of female infertility. Consistent findings were also evident after dividing participants into 4 subgroups based on CVAI quartiles. Additionally, ROC curves indicated that CVAI exhibited the most robust diagnostic value for female infertility compared to other indices. Subgroup analyses revealed a robust association between CVAI and infertility across different populations.ConclusionFemales with elevated CVAI levels faced a significantly heightened risk of infertility in the United States. CVAI holds promise as a valuable tool for stratifying the risk of infertility.https://www.frontiersin.org/articles/10.3389/fendo.2024.1488309/fullvisceral adipose tissuefemale infertilityNHANESbiomarkersobesity |
| spellingShingle | Dongli Guo Ruiya Wang Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study Frontiers in Endocrinology visceral adipose tissue female infertility NHANES biomarkers obesity |
| title | Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study |
| title_full | Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study |
| title_fullStr | Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study |
| title_full_unstemmed | Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study |
| title_short | Association between visceral adipose surrogates and infertility among reproductive-aged females: a cross-sectional study |
| title_sort | association between visceral adipose surrogates and infertility among reproductive aged females a cross sectional study |
| topic | visceral adipose tissue female infertility NHANES biomarkers obesity |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1488309/full |
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