Histopathological changes in the trabecular meshwork in primary congenital glaucoma
Purpose: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Methods: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) we...
Saved in:
| Main Author: | |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-06-01
|
| Series: | American Journal of Ophthalmology Case Reports |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2451993625000933 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Summary: | Purpose: To evaluate the morphological changes in the ex-vivo trabecular meshwork TM specimens from patients with primary congenital glaucoma. Methods: Five trabecular meshwork (TM) specimens obtained after microincisional trabeculectomy from 4 patients with primary congenital glaucoma (mean age) were analyzed using hematological and eosin staining. Results: The trabecular meshwork in PCG showed an expansion of the juxtacanalicular and corneoscleral meshwork regions with increased cellularity, thickened TM beams, prominent spindle-shaped nuclei suggesting epithelial mesenchymal transformation predominantly and two morphologically distinct zones of the juxtacanalicular region. Conclusions: Increased cellularity, zonal expansion and mesenchymal changes in specific TM regions suggest aberrant differentiation and differential dysgenesis of different TM regions in PCG. |
|---|---|
| ISSN: | 2451-9936 |