Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review
The authors presented a complete comprehensive analysis of the combined data of 11 cross-sectional (static) and 11 longitudinal cohort studies with follow-up durations of 5 to 14 years, 16 case-control studies, as well as 3 systemic meta-analyses and 1 “umbrella” study evaluating the scientific hypo...
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| Format: | Article |
| Language: | Russian |
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Ophthalmology Publishing Group
2022-07-01
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| Series: | Oftalʹmologiâ |
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| Online Access: | https://www.ophthalmojournal.com/opht/article/view/1841 |
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| author | V. G. Likhvantseva S. G. Kapkova A. S. Gevorgyan E. Yu. Nekrasova |
| author_facet | V. G. Likhvantseva S. G. Kapkova A. S. Gevorgyan E. Yu. Nekrasova |
| author_sort | V. G. Likhvantseva |
| collection | DOAJ |
| description | The authors presented a complete comprehensive analysis of the combined data of 11 cross-sectional (static) and 11 longitudinal cohort studies with follow-up durations of 5 to 14 years, 16 case-control studies, as well as 3 systemic meta-analyses and 1 “umbrella” study evaluating the scientific hypothesis that hypermetropia is a risk factor for the development of age-related macular degeneration (AMD). In these studies, AMD was verified against the diagnostic criteria of three different classification systems: those of the National Eye Institute (USA), the International System for the Study of Age-Related Maculopathy, and the Wisconsin Classification WARMGS. A total of 82308 patients with AMD were enrolled. 3 baseline indicators in the population were analyzed: the initial hypermetropia, the spherical coefficient (SE) and the axial length of the eye (AL), on the one hand, and the prevalence of AMD, on the other hand. Traditional statistical indicators were calculated: the risk ratio (RR) of AMD among hypermetropes compared to emetropes and a 95 % confidence interval (CI). Pooled data from meta-analyses showed significant associations between farsightedness, SE, AL, and the prevalence of early AMD. The combined RR and 95 % CI were: 1.13 (1.06–1.20), 1.10 (1.07–1.14), and 0.79 (0.73–0.85), respectively. An increase in SE by diopter was correlated with early AMD (RR 1.06; 95 % CI 1.02–1.10). The late AMD did not confirm its association with the refractive error. The umbrella meta-analysis lowered the statistical significance of this association for early AMD (RR 1.08, 95 % CI 1.01–1.18); with late AMD (RR 0.84, 95 % CI 0.77–0.91). In general, experts came to the conclusion that the likelihood of developing AMD depends on the refractive status of the patient. |
| format | Article |
| id | doaj-art-9267ea8f6f554a00be0a52ba8c302f9d |
| institution | DOAJ |
| issn | 1816-5095 2500-0845 |
| language | Russian |
| publishDate | 2022-07-01 |
| publisher | Ophthalmology Publishing Group |
| record_format | Article |
| series | Oftalʹmologiâ |
| spelling | doaj-art-9267ea8f6f554a00be0a52ba8c302f9d2025-08-20T03:01:51ZrusOphthalmology Publishing GroupOftalʹmologiâ1816-50952500-08452022-07-0119225526410.18008/1816-5095-2022-2-255-264893Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. ReviewV. G. Likhvantseva0S. G. Kapkova1A. S. Gevorgyan2E. Yu. Nekrasova3Federal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of RussiaFederal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of RussiaFederal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of RussiaFederal Scientific and Clinical Center for Specialized Types of Medical Care and Medical Technologies FMBA of RussiaThe authors presented a complete comprehensive analysis of the combined data of 11 cross-sectional (static) and 11 longitudinal cohort studies with follow-up durations of 5 to 14 years, 16 case-control studies, as well as 3 systemic meta-analyses and 1 “umbrella” study evaluating the scientific hypothesis that hypermetropia is a risk factor for the development of age-related macular degeneration (AMD). In these studies, AMD was verified against the diagnostic criteria of three different classification systems: those of the National Eye Institute (USA), the International System for the Study of Age-Related Maculopathy, and the Wisconsin Classification WARMGS. A total of 82308 patients with AMD were enrolled. 3 baseline indicators in the population were analyzed: the initial hypermetropia, the spherical coefficient (SE) and the axial length of the eye (AL), on the one hand, and the prevalence of AMD, on the other hand. Traditional statistical indicators were calculated: the risk ratio (RR) of AMD among hypermetropes compared to emetropes and a 95 % confidence interval (CI). Pooled data from meta-analyses showed significant associations between farsightedness, SE, AL, and the prevalence of early AMD. The combined RR and 95 % CI were: 1.13 (1.06–1.20), 1.10 (1.07–1.14), and 0.79 (0.73–0.85), respectively. An increase in SE by diopter was correlated with early AMD (RR 1.06; 95 % CI 1.02–1.10). The late AMD did not confirm its association with the refractive error. The umbrella meta-analysis lowered the statistical significance of this association for early AMD (RR 1.08, 95 % CI 1.01–1.18); with late AMD (RR 0.84, 95 % CI 0.77–0.91). In general, experts came to the conclusion that the likelihood of developing AMD depends on the refractive status of the patient.https://www.ophthalmojournal.com/opht/article/view/1841age-related macular degenerationrisk factorrefractive errorhyperopiasystematic reviewmeta-analysis |
| spellingShingle | V. G. Likhvantseva S. G. Kapkova A. S. Gevorgyan E. Yu. Nekrasova Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review Oftalʹmologiâ age-related macular degeneration risk factor refractive error hyperopia systematic review meta-analysis |
| title | Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review |
| title_full | Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review |
| title_fullStr | Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review |
| title_full_unstemmed | Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review |
| title_short | Hypermetropia as a Risk Factor for Age-Related Macular Degeneration. Review |
| title_sort | hypermetropia as a risk factor for age related macular degeneration review |
| topic | age-related macular degeneration risk factor refractive error hyperopia systematic review meta-analysis |
| url | https://www.ophthalmojournal.com/opht/article/view/1841 |
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