Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model
Objective:To study on the mechanism of Jingui Shenqi pill treatment of kidney-yang deficiency from the angle of differential protein.Methods:We established the model of kidney-yang deficiency rats, set up the normal group, the kidney-yang deficiency group and the traditional Chinese medicine group (...
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| Format: | Article |
| Language: | English |
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Editorial Office of Rehabilitation Medicine
2017-02-01
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| Series: | 康复学报 |
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| Online Access: | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.01024 |
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| author | Naixi ZHENG Zhengxuan ZHAN Yingjie ZHANG Xu WANG Ziyi ZHANG Youxin SU |
| author_facet | Naixi ZHENG Zhengxuan ZHAN Yingjie ZHANG Xu WANG Ziyi ZHANG Youxin SU |
| author_sort | Naixi ZHENG |
| collection | DOAJ |
| description | Objective:To study on the mechanism of Jingui Shenqi pill treatment of kidney-yang deficiency from the angle of differential protein.Methods:We established the model of kidney-yang deficiency rats, set up the normal group, the kidney-yang deficiency group and the traditional Chinese medicine group (Jingui Shenqi pill group). We used two-dimensional electrophoresis (2-DE) to show the proteomic maps of femoral cortical bone, compared the differential protein spots between the groups, analyzed and identified them by mass spectrometry.Results:There were 480 discernible proteins points in each 2-DE gel map. Compared with the normal group, the kidney-yang deficiency group had 16 differentially expressed proteins. After treatment with Jingui Shenqi pill, in the kidney-yang deficiency model rats, the up-regulated expression of Apoa1, Hspd1 and the down-regulated expression of Tpm3, Arhgdib, Colla1 and Sri were back-adjusted.Conclusion:Jingui Shenqi pill in the treatment of kidney-yang deficiency is related to adjust the protein expression of femoral cortical bone in rats. Those proteins involve Apoa1, Hspd1, Tpm3, Arhgdib, Colla1 and Sri. |
| format | Article |
| id | doaj-art-9266cdd0366142999b19d4c3c50157b8 |
| institution | Kabale University |
| issn | 2096-0328 |
| language | English |
| publishDate | 2017-02-01 |
| publisher | Editorial Office of Rehabilitation Medicine |
| record_format | Article |
| series | 康复学报 |
| spelling | doaj-art-9266cdd0366142999b19d4c3c50157b82025-01-14T10:05:55ZengEditorial Office of Rehabilitation Medicine康复学报2096-03282017-02-0127242823097001Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats ModelNaixi ZHENGZhengxuan ZHANYingjie ZHANGXu WANGZiyi ZHANGYouxin SUObjective:To study on the mechanism of Jingui Shenqi pill treatment of kidney-yang deficiency from the angle of differential protein.Methods:We established the model of kidney-yang deficiency rats, set up the normal group, the kidney-yang deficiency group and the traditional Chinese medicine group (Jingui Shenqi pill group). We used two-dimensional electrophoresis (2-DE) to show the proteomic maps of femoral cortical bone, compared the differential protein spots between the groups, analyzed and identified them by mass spectrometry.Results:There were 480 discernible proteins points in each 2-DE gel map. Compared with the normal group, the kidney-yang deficiency group had 16 differentially expressed proteins. After treatment with Jingui Shenqi pill, in the kidney-yang deficiency model rats, the up-regulated expression of Apoa1, Hspd1 and the down-regulated expression of Tpm3, Arhgdib, Colla1 and Sri were back-adjusted.Conclusion:Jingui Shenqi pill in the treatment of kidney-yang deficiency is related to adjust the protein expression of femoral cortical bone in rats. Those proteins involve Apoa1, Hspd1, Tpm3, Arhgdib, Colla1 and Sri.http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.01024kidney-yang deficiencyJingui Shenqi pillfemoral cortical bonedifferential proteins |
| spellingShingle | Naixi ZHENG Zhengxuan ZHAN Yingjie ZHANG Xu WANG Ziyi ZHANG Youxin SU Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model 康复学报 kidney-yang deficiency Jingui Shenqi pill femoral cortical bone differential proteins |
| title | Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model |
| title_full | Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model |
| title_fullStr | Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model |
| title_full_unstemmed | Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model |
| title_short | Effect of Jingui Shenqi Pill on the Differential Proteins in Femoral Cortical Bone of Kidney-yang Deficiency Rats Model |
| title_sort | effect of jingui shenqi pill on the differential proteins in femoral cortical bone of kidney yang deficiency rats model |
| topic | kidney-yang deficiency Jingui Shenqi pill femoral cortical bone differential proteins |
| url | http://kfxb.publish.founderss.cn/thesisDetails#10.3724/SP.J.1329.2017.01024 |
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