Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome
Abstract Introduction Phototherapeutic keratectomy (PTK) is a treatment for recurrent corneal erosion syndrome (RCES). The aim of this study was to investigate whether deeper ablations yielded greater success rates. Methods Retrospective case notes review with prospective patient-reported outcome me...
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Adis, Springer Healthcare
2024-11-01
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| Series: | Ophthalmology and Therapy |
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| Online Access: | https://doi.org/10.1007/s40123-024-01070-2 |
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| author | Kunal A. Gadhvi Georgios Vakros Alfredo Borgia Kirithika Muthusamy Laura de Benito-Llopis Alexander C. Day Daniel M. Gore |
| author_facet | Kunal A. Gadhvi Georgios Vakros Alfredo Borgia Kirithika Muthusamy Laura de Benito-Llopis Alexander C. Day Daniel M. Gore |
| author_sort | Kunal A. Gadhvi |
| collection | DOAJ |
| description | Abstract Introduction Phototherapeutic keratectomy (PTK) is a treatment for recurrent corneal erosion syndrome (RCES). The aim of this study was to investigate whether deeper ablations yielded greater success rates. Methods Retrospective case notes review with prospective patient-reported outcome measures for all patients who had undergone PTK for RCES at a single tertiary referral unit. Patients received treatment with the Schwind Amaris® 750 s excimer laser. The primary outcome measure was recurrence-free survival of patients with ablation depth ≥ 15 µm compared to < 15 µm. Results Seventy eyes of 63 patients were included for analysis, of whom 39 (56%) had preceding trauma and 20 (29%) had epithelial basement membrane dystrophy (EBMD), with the remaining 11 (15%) of unknown aetiology. Twenty eyes (29%) received an ablation ≥ 15 µm (mean ablation depth 16.85 ± 3.4 µm) and 50 (71%) received < 15 µm (mean ablation depth 9.26 ± 1.5 µm). Overall, 65 eyes (93%) reported a subjective improvement in symptoms, with 46 (66%) remaining completely symptom free at the last follow-up [mean follow-up 24 (range, 9–48) months]. Eighty-five per cent of eyes in the ≥ 15 µm group remained symptom free compared to 58% of those with < 15 µm (p = 0.036). Conclusion PTK is an effective treatment for RCES, with deeper ablations yielding longer symptom-free survival. |
| format | Article |
| id | doaj-art-9265733f00f8494d9dbcd9d5279f741b |
| institution | Kabale University |
| issn | 2193-8245 2193-6528 |
| language | English |
| publishDate | 2024-11-01 |
| publisher | Adis, Springer Healthcare |
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| series | Ophthalmology and Therapy |
| spelling | doaj-art-9265733f00f8494d9dbcd9d5279f741b2025-01-12T12:10:51ZengAdis, Springer HealthcareOphthalmology and Therapy2193-82452193-65282024-11-0114114115210.1007/s40123-024-01070-2Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion SyndromeKunal A. Gadhvi0Georgios Vakros1Alfredo Borgia2Kirithika Muthusamy3Laura de Benito-Llopis4Alexander C. Day5Daniel M. Gore6Department of Corneal Diseases, St. Paul’s Eye Unit, Royal Liverpool University HospitalDepartment of Corneal and External Eye Diseases, Moorfields Eye HospitalDepartment of Corneal Diseases, St. Paul’s Eye Unit, Royal Liverpool University HospitalDepartment of Corneal and External Eye Diseases, Moorfields Eye HospitalDepartment of Corneal and External Eye Diseases, Moorfields Eye HospitalDepartment of Corneal and External Eye Diseases, Moorfields Eye HospitalDepartment of Corneal and External Eye Diseases, Moorfields Eye HospitalAbstract Introduction Phototherapeutic keratectomy (PTK) is a treatment for recurrent corneal erosion syndrome (RCES). The aim of this study was to investigate whether deeper ablations yielded greater success rates. Methods Retrospective case notes review with prospective patient-reported outcome measures for all patients who had undergone PTK for RCES at a single tertiary referral unit. Patients received treatment with the Schwind Amaris® 750 s excimer laser. The primary outcome measure was recurrence-free survival of patients with ablation depth ≥ 15 µm compared to < 15 µm. Results Seventy eyes of 63 patients were included for analysis, of whom 39 (56%) had preceding trauma and 20 (29%) had epithelial basement membrane dystrophy (EBMD), with the remaining 11 (15%) of unknown aetiology. Twenty eyes (29%) received an ablation ≥ 15 µm (mean ablation depth 16.85 ± 3.4 µm) and 50 (71%) received < 15 µm (mean ablation depth 9.26 ± 1.5 µm). Overall, 65 eyes (93%) reported a subjective improvement in symptoms, with 46 (66%) remaining completely symptom free at the last follow-up [mean follow-up 24 (range, 9–48) months]. Eighty-five per cent of eyes in the ≥ 15 µm group remained symptom free compared to 58% of those with < 15 µm (p = 0.036). Conclusion PTK is an effective treatment for RCES, with deeper ablations yielding longer symptom-free survival.https://doi.org/10.1007/s40123-024-01070-2PTKPhototherapeutic keratectomyRCESRecurrent corneal erosion syndromeEBMDEpithelial basement membrane dystrophy |
| spellingShingle | Kunal A. Gadhvi Georgios Vakros Alfredo Borgia Kirithika Muthusamy Laura de Benito-Llopis Alexander C. Day Daniel M. Gore Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome Ophthalmology and Therapy PTK Phototherapeutic keratectomy RCES Recurrent corneal erosion syndrome EBMD Epithelial basement membrane dystrophy |
| title | Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome |
| title_full | Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome |
| title_fullStr | Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome |
| title_full_unstemmed | Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome |
| title_short | Ablation Depth-Dependent Survival Analysis of Phototherapeutic Keratectomy for Recurrent Corneal Erosion Syndrome |
| title_sort | ablation depth dependent survival analysis of phototherapeutic keratectomy for recurrent corneal erosion syndrome |
| topic | PTK Phototherapeutic keratectomy RCES Recurrent corneal erosion syndrome EBMD Epithelial basement membrane dystrophy |
| url | https://doi.org/10.1007/s40123-024-01070-2 |
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