P2X7 Receptor Function in Bone-Related Cancer
Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host interactions, and metastatization. This paper s...
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| Format: | Article |
| Language: | English |
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Wiley
2012-01-01
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| Series: | Journal of Osteoporosis |
| Online Access: | http://dx.doi.org/10.1155/2012/637863 |
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| _version_ | 1832558260458094592 |
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| author | Elena Adinolfi Francesca Amoroso Anna Lisa Giuliani |
| author_facet | Elena Adinolfi Francesca Amoroso Anna Lisa Giuliani |
| author_sort | Elena Adinolfi |
| collection | DOAJ |
| description | Modulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host interactions, and metastatization. This paper summarizes recent findings on expression and function of P2X7 receptor for extracellular ATP in primary and metastatic bone cancers. Search of mRNA expression microchip databases and literature analysis demonstrate a high expression of P2X7 in primary bone tumors as well as in other malignancies such as multiple myeloma, neuroblastoma, breast, and prostate cancer. Evidence that P2X7 triggers NFATc1, PI3K/Akt, ROCK, and VEGF pathways in osteoblasts promoting either primary tumor development or osteoblastic lesions is also reported. Moreover, P2X7 receptor is involved in osteoclast differentiation, RANKL expression, matrix metalloproteases and cathepsin secretion thus promoting bone resorption and osteolytic lesions. Taken together these data point to a pivotal role for the P2X7 receptor in bone cancer biology. |
| format | Article |
| id | doaj-art-924fa0a655bc4b639567db56e7bec7dc |
| institution | Kabale University |
| issn | 2090-8059 2042-0064 |
| language | English |
| publishDate | 2012-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of Osteoporosis |
| spelling | doaj-art-924fa0a655bc4b639567db56e7bec7dc2025-02-03T01:32:46ZengWileyJournal of Osteoporosis2090-80592042-00642012-01-01201210.1155/2012/637863637863P2X7 Receptor Function in Bone-Related CancerElena Adinolfi0Francesca Amoroso1Anna Lisa Giuliani2Department of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, ItalyDepartment of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, ItalyDepartment of Experimental and Diagnostic Medicine, Section of General Pathology, University of Ferrara, Via Borsari 46, 44121 Ferrara, ItalyModulation of tumor microenvironment by different mediators is central in determining neoplastic formation and progression. Among these molecules extracellular ATP is emerging as a good candidate in promoting cell growth, neovascularization, tumor-host interactions, and metastatization. This paper summarizes recent findings on expression and function of P2X7 receptor for extracellular ATP in primary and metastatic bone cancers. Search of mRNA expression microchip databases and literature analysis demonstrate a high expression of P2X7 in primary bone tumors as well as in other malignancies such as multiple myeloma, neuroblastoma, breast, and prostate cancer. Evidence that P2X7 triggers NFATc1, PI3K/Akt, ROCK, and VEGF pathways in osteoblasts promoting either primary tumor development or osteoblastic lesions is also reported. Moreover, P2X7 receptor is involved in osteoclast differentiation, RANKL expression, matrix metalloproteases and cathepsin secretion thus promoting bone resorption and osteolytic lesions. Taken together these data point to a pivotal role for the P2X7 receptor in bone cancer biology.http://dx.doi.org/10.1155/2012/637863 |
| spellingShingle | Elena Adinolfi Francesca Amoroso Anna Lisa Giuliani P2X7 Receptor Function in Bone-Related Cancer Journal of Osteoporosis |
| title | P2X7 Receptor Function in Bone-Related Cancer |
| title_full | P2X7 Receptor Function in Bone-Related Cancer |
| title_fullStr | P2X7 Receptor Function in Bone-Related Cancer |
| title_full_unstemmed | P2X7 Receptor Function in Bone-Related Cancer |
| title_short | P2X7 Receptor Function in Bone-Related Cancer |
| title_sort | p2x7 receptor function in bone related cancer |
| url | http://dx.doi.org/10.1155/2012/637863 |
| work_keys_str_mv | AT elenaadinolfi p2x7receptorfunctioninbonerelatedcancer AT francescaamoroso p2x7receptorfunctioninbonerelatedcancer AT annalisagiuliani p2x7receptorfunctioninbonerelatedcancer |