Lipoprotein X Causes Renal Disease in LCAT Deficiency.

Lipoprotein X Causes Renal Disease in LCAT Deficiency.

Human familial lecithin:cholesterol acyltransferase (LCAT) deficiency (FLD) is characterized by low HDL, accumulation of an abnormal cholesterol-rich multilamellar particle called lipoprotein-X (LpX) in plasma, and renal disease. The aim of our study was to determine if LpX is nephrotoxic and to gai...

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Main Authors: Alice Ossoli, Edward B Neufeld, Seth G Thacker, Boris Vaisman, Milton Pryor, Lita A Freeman, Christine A Brantner, Irina Baranova, Nicolás O Francone, Stephen J Demosky, Cecilia Vitali, Monica Locatelli, Mauro Abbate, Carlamaria Zoja, Guido Franceschini, Laura Calabresi, Alan T Remaley
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2016-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0150083
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