Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey
IntroductionDysmenorrhea symptoms are frequent and often self-treated using non-prescription medicines.MethodsTo further characterize women with dysmenorrhea using a combination of hyoscine butylbromide plus paracetamol (PLUS) for self-management of their complaints, we performed a secondary analysi...
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Frontiers Media S.A.
2025-04-01
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| author | Kathrin Stewen Selina Miehle Harald Weigmann Roxana Schwab |
| author_facet | Kathrin Stewen Selina Miehle Harald Weigmann Roxana Schwab |
| author_sort | Kathrin Stewen |
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| description | IntroductionDysmenorrhea symptoms are frequent and often self-treated using non-prescription medicines.MethodsTo further characterize women with dysmenorrhea using a combination of hyoscine butylbromide plus paracetamol (PLUS) for self-management of their complaints, we performed a secondary analysis of a published pharmacy-based patient survey.ResultsA total of 314 women (mean age: 32.3 years) with dysmenorrhea reported a pain and cramps intensity of 7.45 ± 2.13 (means ± SD) on a 0–10 Likert scale, which was reduced to 2.86 ± 1.81 upon treatment. Associated impairments of work/daily chores, leisure activities, and sleep were improved by 64.6, 62.2, and 70.4%, respectively. The onset of symptom relief was within 60 min in 84.7%. Tolerability was rated as very good or good by 97.2%; 82.8% were repeat users, 97.5% reported their intention to purchase the product again, and 97.1% reported their intention to recommend it to relatives, friends, and colleagues.DiscussionThese findings confirm the efficacy and tolerability data on PLUS from randomized controlled trials in a larger group of women conducting self-management of their dysmenorrhea in a real-world setting. Future studies should compare PLUS to other non-prescription treatments. |
| format | Article |
| id | doaj-art-924cebc0a1a040da9879ad8644baa2bb |
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| issn | 2296-858X |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Medicine |
| spelling | doaj-art-924cebc0a1a040da9879ad8644baa2bb2025-08-20T02:26:26ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2025-04-011210.3389/fmed.2025.15810591581059Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient surveyKathrin Stewen0Selina Miehle1Harald Weigmann2Roxana Schwab3Department of Obstetrics and Gynecology, University Medical Center of Johannes Gutenberg University, Mainz, GermanySanofi, Frankfurt am Main, GermanySanofi, Frankfurt am Main, GermanyDepartment of Obstetrics and Gynecology, University Medical Center of Johannes Gutenberg University, Mainz, GermanyIntroductionDysmenorrhea symptoms are frequent and often self-treated using non-prescription medicines.MethodsTo further characterize women with dysmenorrhea using a combination of hyoscine butylbromide plus paracetamol (PLUS) for self-management of their complaints, we performed a secondary analysis of a published pharmacy-based patient survey.ResultsA total of 314 women (mean age: 32.3 years) with dysmenorrhea reported a pain and cramps intensity of 7.45 ± 2.13 (means ± SD) on a 0–10 Likert scale, which was reduced to 2.86 ± 1.81 upon treatment. Associated impairments of work/daily chores, leisure activities, and sleep were improved by 64.6, 62.2, and 70.4%, respectively. The onset of symptom relief was within 60 min in 84.7%. Tolerability was rated as very good or good by 97.2%; 82.8% were repeat users, 97.5% reported their intention to purchase the product again, and 97.1% reported their intention to recommend it to relatives, friends, and colleagues.DiscussionThese findings confirm the efficacy and tolerability data on PLUS from randomized controlled trials in a larger group of women conducting self-management of their dysmenorrhea in a real-world setting. Future studies should compare PLUS to other non-prescription treatments.https://www.frontiersin.org/articles/10.3389/fmed.2025.1581059/fulldysmenorrheahyoscine butylbromideparacetamolfixed-dose combinationpharmacy-based patient surveyreal-world evidence |
| spellingShingle | Kathrin Stewen Selina Miehle Harald Weigmann Roxana Schwab Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey Frontiers in Medicine dysmenorrhea hyoscine butylbromide paracetamol fixed-dose combination pharmacy-based patient survey real-world evidence |
| title | Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey |
| title_full | Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey |
| title_fullStr | Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey |
| title_full_unstemmed | Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey |
| title_short | Real-world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea: a patient survey |
| title_sort | real world effects of hyoscine butylbromide combined with paracetamol in women with dysmenorrhea a patient survey |
| topic | dysmenorrhea hyoscine butylbromide paracetamol fixed-dose combination pharmacy-based patient survey real-world evidence |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2025.1581059/full |
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