SMAD3 orchestrates RNF167 and STAMBPL1-mediated Sestrin2 ubiquitination to drive gastric cancer progression

SMAD3 orchestrates RNF167 and STAMBPL1-mediated Sestrin2 ubiquitination to drive gastric cancer progression

Abstract Background Gastric cancer (GC) continues to pose a significant global health burden, necessitating a thorough understanding of the molecular mechanisms driving its progression. This study aimed to investigate the regulatory role of SMAD3 in modulating Sestrin2 ubiquitination stability and i...

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Bibliographic Details
Main Authors:	Ning Zhang, Na Zhao, Hainan Zhang, Le Yao, Hongtao Si
Format:	Article
Language:	English
Published:	BMC 2025-08-01
Series:	Cell Division
Subjects:	SMAD family member 3 Sestrin2 Ubiquitination Gastric Cancer Cell proliferation
Online Access:	https://doi.org/10.1186/s13008-025-00163-z
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