Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022)
Abstract Yersinia enterocolitica is a significant foodborne pathogen causing gastrointestinal illnesses worldwide. This study investigates the prevalence and genomic characteristics of Y. enterocolitica to assess potential health risks in southeastern China, a region lacking mandatory yersiniosis mo...
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Springer
2025-07-01
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| Series: | Applied Microbiology and Biotechnology |
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| Online Access: | https://doi.org/10.1007/s00253-025-13500-7 |
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| author | Lei Fang Shuxuan Li Jie Rong Shengkai Li Yuwen Zhang Huihuang Lou Zhongbi Xie Yuqin Hu Yuejin Wu Airong Xie Yi Li |
| author_facet | Lei Fang Shuxuan Li Jie Rong Shengkai Li Yuwen Zhang Huihuang Lou Zhongbi Xie Yuqin Hu Yuejin Wu Airong Xie Yi Li |
| author_sort | Lei Fang |
| collection | DOAJ |
| description | Abstract Yersinia enterocolitica is a significant foodborne pathogen causing gastrointestinal illnesses worldwide. This study investigates the prevalence and genomic characteristics of Y. enterocolitica to assess potential health risks in southeastern China, a region lacking mandatory yersiniosis monitoring. From 2939 samples collected between 2008 and 2022, 105 isolates were recovered. The highest prevalence was found in rodents (8.1%), followed by retail meats (7.1%), other foods (3.7%), and human clinical cases (0.8%). In addition to meats and rodents, ready-to-eat salads, seafood, and frozen food products were identified as potential transmission vehicles. Various bioserotypes and sequence types (STs) was identified, including twelve previously unreported STs. Biotype 1A, exhibiting greater genetic diversity than more pathogenic biotypes (3 and 4), was frequently found in human clinical cases. Phylogenetic analysis revealed two main lineages, with isolates primarily clustered by biotype and pathogenic traits. Antimicrobial susceptibility testing revealed 46.7% (49/105) of isolates were multidrug resistant (MDR), with frequent resistance to polymyxin B (100%), azithromycin (50.5%), and sulfanilamide isoxazole (31.4%). These findings highlight the ecological complexity and diversity of Y. enterocolitica, especially non-pathogenic biotype 1A strains, and underscore the need for enhanced food safety and antimicrobial stewardship to mitigate the public health impact of Y. enterocolitica infections. Key points Biotype 1 A strains exhibited greater genetic diversity than pathogenic biotypes. Pathogenic strains were mainly associated with lineage HC1490_2, not HC1490_10. Higher MDR levels were observed in biotype 3 and 4 strains. |
| format | Article |
| id | doaj-art-924989da444e4df7a1fd9fac3885ac12 |
| institution | DOAJ |
| issn | 1432-0614 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | Springer |
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| series | Applied Microbiology and Biotechnology |
| spelling | doaj-art-924989da444e4df7a1fd9fac3885ac122025-08-20T03:04:26ZengSpringerApplied Microbiology and Biotechnology1432-06142025-07-01109111410.1007/s00253-025-13500-7Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022)Lei Fang0Shuxuan Li1Jie Rong2Shengkai Li3Yuwen Zhang4Huihuang Lou5Zhongbi Xie6Yuqin Hu7Yuejin Wu8Airong Xie9Yi Li10Department of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityNanfang College GuangzhouLotabiome Biotechnology IncKey Laboratory of Alkene-carbon Fibres-based Technology & Application for Detection of Major Infectious Diseases, MOE Key Laboratory of Geriatric Diseases and Immunology, Cancer Institute, Suzhou Medical College, Soochow UniversitySchool of Public Health, Hangzhou Medical CollegeWenzhou Center for Disease Control and PreventionWenzhou Center for Disease Control and PreventionWenzhou Center for Disease Control and PreventionDepartment of Critical Care Medicine, Sir Run Run Shaw Hospital, College of Medicine, Zhejiang UniversityWenzhou Center for Disease Control and PreventionWenzhou Center for Disease Control and PreventionAbstract Yersinia enterocolitica is a significant foodborne pathogen causing gastrointestinal illnesses worldwide. This study investigates the prevalence and genomic characteristics of Y. enterocolitica to assess potential health risks in southeastern China, a region lacking mandatory yersiniosis monitoring. From 2939 samples collected between 2008 and 2022, 105 isolates were recovered. The highest prevalence was found in rodents (8.1%), followed by retail meats (7.1%), other foods (3.7%), and human clinical cases (0.8%). In addition to meats and rodents, ready-to-eat salads, seafood, and frozen food products were identified as potential transmission vehicles. Various bioserotypes and sequence types (STs) was identified, including twelve previously unreported STs. Biotype 1A, exhibiting greater genetic diversity than more pathogenic biotypes (3 and 4), was frequently found in human clinical cases. Phylogenetic analysis revealed two main lineages, with isolates primarily clustered by biotype and pathogenic traits. Antimicrobial susceptibility testing revealed 46.7% (49/105) of isolates were multidrug resistant (MDR), with frequent resistance to polymyxin B (100%), azithromycin (50.5%), and sulfanilamide isoxazole (31.4%). These findings highlight the ecological complexity and diversity of Y. enterocolitica, especially non-pathogenic biotype 1A strains, and underscore the need for enhanced food safety and antimicrobial stewardship to mitigate the public health impact of Y. enterocolitica infections. Key points Biotype 1 A strains exhibited greater genetic diversity than pathogenic biotypes. Pathogenic strains were mainly associated with lineage HC1490_2, not HC1490_10. Higher MDR levels were observed in biotype 3 and 4 strains.https://doi.org/10.1007/s00253-025-13500-7Yersinia enterocoliticaBiotype 1 AGenomic epidemiologyFoodborne transmissionZoonotic infection |
| spellingShingle | Lei Fang Shuxuan Li Jie Rong Shengkai Li Yuwen Zhang Huihuang Lou Zhongbi Xie Yuqin Hu Yuejin Wu Airong Xie Yi Li Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022) Applied Microbiology and Biotechnology Yersinia enterocolitica Biotype 1 A Genomic epidemiology Foodborne transmission Zoonotic infection |
| title | Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022) |
| title_full | Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022) |
| title_fullStr | Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022) |
| title_full_unstemmed | Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022) |
| title_short | Prevalence and genomic insights into Yersinia enterocolitica in Southeastern China (2008–2022) |
| title_sort | prevalence and genomic insights into yersinia enterocolitica in southeastern china 2008 2022 |
| topic | Yersinia enterocolitica Biotype 1 A Genomic epidemiology Foodborne transmission Zoonotic infection |
| url | https://doi.org/10.1007/s00253-025-13500-7 |
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