Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)
The aim of the present study is to explore the bacterial diversity within the gut microbiome of chronic inflammatory demyelinating polyneuropathy patient. A stool sample was collected and analyzed to study the gut microbiota through bacterial 16S rRNA gene sequencing. The gut microbiota of chronic...
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Amaltea Medical Publishing House
2024-09-01
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| Series: | Romanian Journal of Neurology |
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| Online Access: | https://rjn.com.ro/articles/2024.3/RJN_2024_3_Art-03.pdf |
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| author | Katia Djenadi Lamine Bournine Lila Anouche-Kherdouche Hassan Khechfoud Mounia Azouaou Sarah Hamid Reda Zenagui Mostapha Bachir Bey Kati Djamel Eddine |
| author_facet | Katia Djenadi Lamine Bournine Lila Anouche-Kherdouche Hassan Khechfoud Mounia Azouaou Sarah Hamid Reda Zenagui Mostapha Bachir Bey Kati Djamel Eddine |
| author_sort | Katia Djenadi |
| collection | DOAJ |
| description | The aim of the present study is to explore the bacterial diversity within the gut microbiome of chronic inflammatory demyelinating polyneuropathy patient. A stool sample was collected and analyzed to study the gut microbiota through
bacterial 16S rRNA gene sequencing. The gut microbiota of chronic inflammatory demyelinating polyneuropathy patient exhibited a dominance of Firmicutes and Bacteroides phyla, with 58.19% and 33.31%, respectively. The data showed a notable abundance of Lachnospiraceae bacterium and Bacteroides sp species, 17.79% and 16.56%, respectively within the gut microbiota chronic inflammatory demyelinating polyneuropathy patient. Lachnospiraceae, a member of the Firmicutes phylum, plays a pivotal role in the production of short-chain fatty acids. At high concentration, short-chain fatty acids can trigger autoimmune leading to the chronic inflammatory demyelinating polyneuropathy. These findings strengthen the possible involvement of short-chain fatty acids in the chronic inflammatory demyelinating polyneuropathy pathogenesis process and could pave new paths in its diagnosis and therapies based on regulation of microbiota dysbiosis. |
| format | Article |
| id | doaj-art-9247e24b7d214e589442d77e202cf9bb |
| institution | OA Journals |
| issn | 1843-8148 2069-6094 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | Amaltea Medical Publishing House |
| record_format | Article |
| series | Romanian Journal of Neurology |
| spelling | doaj-art-9247e24b7d214e589442d77e202cf9bb2025-08-20T01:54:58ZengAmaltea Medical Publishing HouseRomanian Journal of Neurology1843-81482069-60942024-09-0123324825510.37897/RJN.2024.3.3Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP)Katia Djenadi0https://orcid.org/0000-0002-0513-0985Lamine Bournine1Lila Anouche-Kherdouche2Hassan Khechfoud3Mounia Azouaou4Sarah Hamid5Reda Zenagui6Mostapha Bachir Bey7Kati Djamel Eddine8Department of Biological Sciences, Faculty of Nature and Life Sciences and Earth Sciences,University of Bouira, Bouira, Algeria; Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, AlgeriaDepartment of Biological Sciences, Faculty of Nature and Life Sciences and Earth Sciences,University of Bouira, Bouira, Algeria; Laboratory of Plant Biotechnology and Ethnobotany, Faculty of Nature and Life Sciences,University Abderrahmane Mira, Bejaia, AlgeriaGeneral practitioner, Beni Maouche, Bejaia, AlgeriaFaculty of Medicine, University of Bejaia, Bejaia, Algeria; Department of Neurosurgery, University-affiliated Hospital, Bejaia AlgeriaFaculty of Medicine, University of Bejaia, Bejaia, AlgeriaLaboratory of Plant Biotechnology and Ethnobotany, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, Algeria Cytogenetic PGD Department, Arnaud De Villeneuve Hospital, Montpellier, France Laboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, AlgeriaLaboratory of Applied Biochemistry, Faculty of Nature and Life Sciences, University of Bejaia, Bejaia, Algeria The aim of the present study is to explore the bacterial diversity within the gut microbiome of chronic inflammatory demyelinating polyneuropathy patient. A stool sample was collected and analyzed to study the gut microbiota through bacterial 16S rRNA gene sequencing. The gut microbiota of chronic inflammatory demyelinating polyneuropathy patient exhibited a dominance of Firmicutes and Bacteroides phyla, with 58.19% and 33.31%, respectively. The data showed a notable abundance of Lachnospiraceae bacterium and Bacteroides sp species, 17.79% and 16.56%, respectively within the gut microbiota chronic inflammatory demyelinating polyneuropathy patient. Lachnospiraceae, a member of the Firmicutes phylum, plays a pivotal role in the production of short-chain fatty acids. At high concentration, short-chain fatty acids can trigger autoimmune leading to the chronic inflammatory demyelinating polyneuropathy. These findings strengthen the possible involvement of short-chain fatty acids in the chronic inflammatory demyelinating polyneuropathy pathogenesis process and could pave new paths in its diagnosis and therapies based on regulation of microbiota dysbiosis.https://rjn.com.ro/articles/2024.3/RJN_2024_3_Art-03.pdfautoimmunegut microbiotadysbiosisfirmicuteslachnospiraceae |
| spellingShingle | Katia Djenadi Lamine Bournine Lila Anouche-Kherdouche Hassan Khechfoud Mounia Azouaou Sarah Hamid Reda Zenagui Mostapha Bachir Bey Kati Djamel Eddine Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) Romanian Journal of Neurology autoimmune gut microbiota dysbiosis firmicutes lachnospiraceae |
| title | Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) |
| title_full | Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) |
| title_fullStr | Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) |
| title_full_unstemmed | Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) |
| title_short | Intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) |
| title_sort | intestinal microflora dysbiosis and resistome in chronic inflammatory demyelinating polyradiculoneuropathy cidp |
| topic | autoimmune gut microbiota dysbiosis firmicutes lachnospiraceae |
| url | https://rjn.com.ro/articles/2024.3/RJN_2024_3_Art-03.pdf |
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